研究

プロジェクト紹介

分子病態治療プロジェクト

がんの遺伝子治療

岡山大学病院では、1996年1月、学内に遺伝子治療臨床研究審査委員会を設置し、21世紀型医療において重要な位置を占めるであろうと期待される遺伝子治療研究を推進してきた。肺癌に対する遺伝子治療プロトコールは同審査委員会の了承を得て、文部省の学術審議会特定研究領域推進分科会バイオサイエンス部会専門委員会および厚生省の厚生科学審議会先端医療技術評価部会において審議され、1998年に文部大臣・厚生大臣からその実施が了承されている。
1999年3月には他施設に先駆け、本邦ではじめての肺癌遺伝子治療である「非小細胞肺癌に対する正常型p53遺伝子発現アデノウイルスベクター及びシスプラチンを用いた遺伝子治療臨床研究」を開始した。この臨床研究は、遺伝子治療では本邦ではじめての多施設共同研究に進み、岡山大学を中心に東京医大、東京慈恵会医大、東北大学が参画し、2005年無事に臨床試験を終了している。
2003年からは遺伝子治療を代表とする一連のトランスレーショナル・リサーチの推進を目的として岡山大学病院内に遺伝子・細胞治療センターが設置され稼動しており、2008年には生物製剤などを用いた治療を行うための先端治療室、及びリサーチナースが治療後の患者をケアする患者回復室などが拡充整備された。

1999年3月 癌に対する遺伝子治療臨床試験を開始

【IN THE NEWS】

 

がんのウイルス治療

最近の分子生物学の進歩により、がん細胞の悪性形質の発現に重要な分子を標的とした抗がん治療の開発が試みられている。従来の抗がん剤は、がん組織での効果を上げるためには投与量を増やす必要があり、全身的な副作用が問題となってきた。また放射線治療では、画像的に描出できない微小転移などは治療できない。がん細胞での選択的増殖能を持つ生物製剤ならば、投与量を低く設定してもがん局所での自律増殖が期待でき、また肉眼的に認知できない微小がんも対象とすることができる。
染色体末端のテロメア長を保つ作用を持つ酵素テロメラーゼは極めて多くのがん細胞でその活性の上昇が知られており、現在、がん治療のターゲットとして最も注目を浴びている分子の一つである。テロメライシン(Telomelysin、開発コード:OBP-301)は、テロメラーゼ構成成分であるhTERT (human telomerase reverse transcriptase) 遺伝子のプロモーターを用いて作成した腫瘍融解ウイルス(Oncolytic Virus)である。テロメラーゼは85%以上のヒト癌でその活性の上昇が知られており、テロメライシンは広範な癌細胞で選択的に増殖し、細胞融解を引き起す。腫瘍内に投与された場合、ウイルスは三次元的に腫瘍組織内に拡散し、連鎖的に細胞死を誘導することで広範囲の腫瘍壊死を生じると考えられる。また、テロメラーゼ活性を持たない正常細胞ではその増殖は制限され、安全性が確保される。このテロメライシンをコア技術として岡山大学発バイオベンチャー オンコリスバイオファーマ(株)を設立し、がんの治療用・診断用医薬品としての臨床開発を推進している。

【IN THE NEWS】

 

がん幹細胞(Cancer Stem Cell)

近年、単一集団と思われていたがんには、自己複製能、造腫瘍性、多分化能を持ち合わせたがん幹細胞を中心に階層性があることが白血病を契機とし、各種固形癌で報告された。
がん幹細胞は、がんが既存の治療に抵抗性である、また一旦消失したがんが再発を起こす、そして転移を起こす、というがん特有の資質の根源であると考えられている。つまり、がん幹細胞を治療し根絶させることこそが究極のがん治療と位置づけられ、近年、消化器癌のがん幹細胞の同定、治療抵抗性の解明、新規治療薬の開発が行われている。
私たちは、胃癌細胞株を用いがん幹細胞の存在を確立し、がん幹細胞が既存の治療に抵抗性であることを見出した。現在、テロメライシンが、既存の治療法とは全く異なる治療メカニズムを有していることから、がん幹細胞をターゲットとした新治療薬としての有効性について検討している。

 

マイクロRNA

マイクロRNAは、タンパク質をコードしない約22塩基長の小さなRNAである。近年、様々ながん組織におけるマイクロRNAの発現異常が明らかとなり、がんの発生、増殖、浸潤、転移などに強く関連するマイクロRNAが次第に明らかになりつつある。
マイクロRNAをターゲットとした臨床応用として、異常なマイクロRNA発現を正常化して腫瘍の成長を抑える新規がん治療法の開発や、血液中の異常なマイクロRNA発現を腫瘍マーカーとして利用する新規がん診断法の開発が進められている。
我々は、がん細胞の増殖を制御するマイクロRNAを同定し、マイクロRNAをターゲットとした新規がん治療法の確立に向けて取り組んでいる。これまで、がん細胞に細胞老化様の増殖停止を起こすマイクロRNA-34を同定した。現在、テロメライシンががん細胞を死滅させる際に働くマイクロRNAの同定を試みている。

 

がんの間質細胞を標的とする治療開発

近年の分子細胞生化学の発展により、その分子標的治療薬によって飛躍的に予後改善を認めるものも出て来ている。また一方で、従来の抗癌剤治療に抗VEGFR抗体であるBevastimabの併用により、より高い抗腫瘍効果が報告されて来ている。そのような事実は旧来の抗腫瘍細胞増殖抑制という抗癌剤のあり方から、癌細胞増殖におけるtumor microenvironmentの重要性または抗腫瘍効果の標的となり得る可能性を示唆している。
そこで、我々は以前より食道癌進展における間質(Stroma)いわゆる腫瘍増殖環境(Tumor microenvironment)に注目し分子標的となりうるsignal transductionの解析を行って来た。これまで我々は食道癌由来のTGFにより活性化した間質での主役を担う線維芽細胞:Myofibroblast(筋線維芽細胞)がVEGFを産生することで癌細胞増殖に必須である微小血管網形成を促進することを新規開発した3次元モデルを用いて解明し、またTGF受容体阻害により癌微小血管新生が抑制されることを現段階で明らかにした。
さらにその活性化した線維芽細胞は癌の浸潤進展への重要性な可能性も指摘されている。特に基底膜を破壊し浸潤する過程や、転移において血管上皮に接着し浸潤して行く際に間質細胞の働きは癌の性質に非常に大きく影響すると言われている。
そこで我々は線維芽細胞を中心とした間質細胞および間質における癌増殖および進展のsignal transductionのさらなる解明およびその鍵となる物質の同定を行い、従来の抗癌剤と違う新たなアプローチとしての治療法として開発を試みている。


1)食道癌細胞株との共培養により活性化した線維芽細胞 緑:線維芽細胞、赤:Alpha-SMA(smooth muscle actin)1

2)食道癌細胞株との共培養により活性化した線維芽細胞 緑:線維芽細胞、赤:Alpha-SMA(smooth muscle actin)2

3)食道癌細胞株 E-cadherinの発現パターン 赤:E-cadherin1

4)食道癌細胞株 E-cadherinの発現パターン 赤:E-cadherin2
   
 
がん微小環境制御による新規治療法の開発

現在まで様々な抗がん剤が開発されてきたが、今だ完全ながんの制御には至っていない。 近年の分子細胞生化学の発展により、腫瘍およびその周囲の環境(Tumor microenvironment)の役割が徐々に解明されてきた。

それに伴いがん治療においてはがん細胞のみを標的にするのではなく、周囲の間質細胞や環境も同時に治療の対象とする事が重要であると認識されるようになった。

我々はその周囲環境の中でも特に鉄に注目し研究を行っている。 がんと鉄については以前から研究が行われており、過剰な鉄が発がんのひとつの原因であることは知られている。 しかしながら鉄を減らす事は、固形癌の治療としては確立されていない。 この理由は鉄をただ減らしただけでは、既存の抗癌剤治療の効果を超えられないためである。 我々は鉄を減らした時に、がん細胞は増殖スピードが落ちるが、 その環境を克服するために血管新生を引き起こされている事を明らかにした。

これはがんの防御反応のひとつであり、我々はこの機構を逆手に取り、 人為的にがんの鉄を減らしたうえで、血管新生阻害薬を投与する事で強い抗腫瘍効果を得る事に成功した。

 

蛍光分子イメージングプロジェクト

血中循環がん細胞(Circulating Tumor Cells: CTC)

テロメライシンはそれ自体を分子標的医薬品としてがん治療に応用できるが、さらに改変を加えることで、生体内でがん組織を可視化するナビゲーション・ツールとしても使用可能である。すなわち、オワンクラゲ由来の蛍光遺伝子GFP (Green Fluorescence Protein)をテロメライシンのE3領域に組み込むことで、診断用ウイルス製剤 テロメスキャン(TelomeScan 、開発コード:OBP-401)を作成した。
テロメライシンはそれ自体を分子標的医薬品としてがん治療に応用できるが、さらに改変を加えることで、生体内でがん組織を可視化するナビゲーション・ツールとしても使用可能である。すなわち、オワンクラゲ由来の蛍光遺伝子GFP (Green Fluorescence Protein)をテロメライシンのE3領域に組み込むことで、診断用ウイルス製剤 テロメスキャン(TelomeScan 、開発コード:OBP-401)を作成した。
近年、末梢血中の浮遊がん細胞の検出は原発巣が認識されないがん患者の早期発見に有効であり、また悪性度評価に基づく予後の予知にも有用であったと報告された。これらに続くように末梢血中の浮遊がん細胞についての報告はその後も近年目立って増えており、がん研究において最も注目を浴びている分野の一つである。テロメスキャンを標識薬剤として末梢血中の浮遊がん細胞に感染させるとGFP陽性細胞として可視化し同定することができ、全く新規のシステムとして末梢血中の浮遊がん細胞を検出できる。また、従来の検出法では活性がなくなったがん細胞も検出されたが、この方法はウイルスの感染が成立することで検出されるため、“生きた”がん細胞のみ検出されることが画期的であり、より臨床におけるがんの状態を反映することができる検出法と考えられる。
実際のがん患者の末梢血浮遊がん細胞をテロメスキャンを用いて約70-80%の感度で検出できている。経過を追って検出すると、末梢血中のGFP陽性細胞数が既存の腫瘍マーカーの推移や臨床所見と連動して推移したと思われる症例が散見された。また腫瘍マーカーが正常値の症例でも臨床所見とGFP陽性細胞数が相関する症例もみられ、既存の腫瘍マーカーに代わって病勢・予後判定に有用である可能性が示唆された。これらの結果から充分臨床応用の有用性が示唆されたと判断し、多施設大規模臨床試験への足掛かりとして、検査会社と提携して臨床研究を進めており、将来的に他の一般施設で同システムを使用できるような検査薬としての応用を目指している。

テロメスキャンによる循環がん細胞の検出

 

外科ナビゲーション・システムの開発

生体内でがん組織や転移リンパ節を検出する試みは画像診断の分野で研究が進んでいるが、手術中に直接検出・診断するシステムは未だ開発されていない。手術の縮小化による低侵襲化を目指す場合にほしい情報の一つに転移リンパ節の有無があり、それを知る方法としてテロメスキャンを活用する。内視鏡などのアクセスを用いてテロメスキャンを原発腫瘍内に局所投与することでリンパ流を経由するウイルスの所属リンパ節への拡散を促す。テロメスキャンはリンパ節内の微小転移巣でがん細胞に感染・増殖して選択的にGFP蛍光を発するため、一定期間の後に開胸あるいは開腹にて転移リンパ節を可視化することができる。
テロメスキャンを標識薬剤とし、ペンプローブ型および鏡視下手術用ビデオスコープ型の高感度GFP蛍光検出装置を用いた微小がん組織診断用の外科手術ナビゲーション・システムを開発中であり、微小リンパ節転移を手術中にリアルタイムに検出してリンパ節郭清範囲を同定する低侵襲外科手術が可能となる。

蛍光分子イメージングによる外科ナビゲーション

【IN THE NEWS】

 

肝胆膵・移植免疫グループ

 肝胆膵・移植免疫グループでは、豊富な肝胆膵手術・肝移植症例を対象とした臨床研究・基礎研究を中心としています。常に臨床へのフィードバックを念頭においた研究を心掛け、研究成果に裏打ちされた基盤のもと更なる治療成績の向上に努めています。
 本邦で生体肝移植が始まってから20年が経過し、’08年日本肝移植研究会の報告では4,292例が集計され岡山大学病院でも’10年7月末までに250例の生体肝移植を施行しています。臓器移植法の改正とともに脳死移植の増加が期待される中、慢性的な脳死ドナー不足、海外での渡航移植制限といった現実から、当面は生体肝移植に頼らざるを得ないのが現状です。症例の蓄積とともに治療成績も日々向上し、生体肝移植の標準化がうたわれる今日ですが、本邦での臓器移植の普及に向けて、そして症例の多様化から更なる治療成績の向上に向けて解決すべき問題は多いと思われます。移植短期予後、長期予後改善に向け、複数の臨床試験・臨床研究を実施中です。
  生体肝移植においては、ドナーの安全性確保の為に十分な残肝を残すことが必須ですが、その結果レシピエントは過小なグラフトSmall for sized graftを余儀なくされるという生体肝移植の宿命ともいえる問題が生じます。過小グラフトを用いた場合には、絶対的グラフト容積の不足に過剰な門脈灌流が加わることによるPortal inflow complianceの破綻からグラフト障害を惹起し、良好な肝再生が得られることなく遷延性の黄疸・腹水、凝固障害を徴候とするSmall-for-size syndromeに苦悩し、移植後死亡の原因となります。Small for size syndromeに対しては、脾動脈経由の門脈減圧策として術前脾動脈塞栓術を考案・導入し、移植術中・術後の門脈減圧効果、術中出血量減少、炎症性サイトカインの減少といった手術の低侵襲化、移植肝機能を改善し得ること前向き臨床研究によって証明しました。現在、有意機序となる肝再生シグナル・Graft組織障害メカニズムを明らかにすべく解析を進め、肝再生・機能評価結果、分子生物学的分析結果との相関性を解析し、臨床応用可能な機能予後予測システムの確立を目指しています。
 生体肝移植の標準化によって、ドナーが多様化するなか、脂肪肝と高齢ドナーを用いた場合の移植予後不良が問題視されています。移植後生着率の向上には、脂肪肝移植・高齢ドナー移植による移植後肝機能不良の病態メカニズムの解明は急務です。脂肪肝移植の肝不全の原因・機序の究明の目的で、マウス肝切除実験を行ってきました。この結果、脂肪肝においては転写因子であるSTAT-3の活性化異常と細胞増殖障害が認められ、移植後肝不全の主因と考えられました。そしてラットを用いた脂肪肝移植において活性化 STAT-3を組み込んだアデノウイルスベクターをex vivoにて遺伝子導入することによって、移植後の肝機能不全を制御することが実証され、本治療戦略の臨床的有効性が示唆されました。さらに前向き臨床試験によるグラフト肝再生シグナルの解析において、高齢ドナーでSTAT-3活性化低下とAKTによる代償機序の減弱を証明しました。今後は更に病態解明に向けて研究を進め、治療法を考案していく予定です。
  外科周術期における栄養療法の有用性が注目されていますが、移植周術期の感染性合併症の軽減、移植予後の向上を目標として、栄養療法介入の意義を検証すべく、BCAA製剤を用いた臨床試験を実施中です。合併症軽減、移植肝機能予後の改善のみならず、間接熱量計を用いた呼吸商の測定から栄養素の燃焼比率を測定し、移植周術期における栄養代謝メカニズムが明らかになりつつあり、生体肝移植における至適栄養療法の確立とともに国内外に向けて情報発信できることを目指しております。
  免疫制御病態の解明として、肝移植後の拒絶と免疫寛容メカニズムを研究テーマとして掲げています。肝臓移植後の患者末梢血で、拒絶と免疫寛容に関与する免疫学的マーカーの解析を行い、どのような細胞が重要な働きを演じているのか解明し、そのデータをもとに、移植前のドナーの末梢血から免疫寛容に関係する細胞を分離し、臓器移植とともにレシピエントに輸注することにより、移植臓器に対する免疫寛容を誘導する細胞療法を開発することを最終目標としています。またC型肝炎に対する肝移植においては、移植時にウイルスが駆除されていない場合、移植後もC型肝炎ウイルスによる肝障害が持続することになりますが、拒絶に伴い血中ウイルス量が減少することが観察され、移植臓器に対するアロ免疫動態との関連が示唆されています。FACS解析システムを使用し、肝移植後の末梢血におけるドナー/レシピエントキメリズム、制御性T細胞、アロ特異的CD4+ T細胞、およびHCV特異的CD8+ T細胞の頻度と機能分子発現を解析し、拒絶とウイルス特異的免疫応答の関連性を検証し、移植後C型肝炎の再燃に対して新たな細胞免疫療法の開発に向け精力的に取り組んでいます。

最近の主な業績
  1. A prognostic model and treatment strategy for intrahepatic recurrence after curative resection of hepatocellular carcinoma.
    Umeda Y, Matsuda H, Sadamori H, Matsukawa H, Yagi T, Fujiwara T. World J Surg. [in press]
  2. Aggressive combined resection of hepatic inferior vena cava, with replacement by a ringed expanded polytetrafluoroethylene graft, in living-donor liver transplantation for hepatocellular carcinoma beyond the Milan criteria.
    Matsuda H, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Satoh D, Utsumi M, Onishi T, Yagi T. J Hepatobiliary Pancreat Sci. [in press]
  3. Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction.
    Ohashi K, Takahashi HK, Mori S, Liu K, Wake H, Sadamori H, Matsuda H, Yagi T, Yoshino T, Nishibori M, Tanaka N. Clin Immunol. 2010 Mar;134(3):345-53.
  4. Refractory response to growth factors impairs liver regeneration after hepatectomy in patients with viral hepatitis.
    Umeda Y, Iwagaki H, Ozaki M, Ogino T, Iwamoto T, Yoshida R, Shinoura S, Matsuda H, Sadamori H, Tanaka N, Yagi T. Hepatogastroenterology. 2009;56(93):971-7.
  5. Anatomical subsegmentectomy in the lateral segment for hepatocellular carcinoma.
    Sadamori H, Matsuda H, Shinoura S, Umeda Y, Yoshida R, Sato D, Utsumi H, Ohnishi T, Yagi T. Hepatogastroenterology. 2009;56(94-95):1511-5.
  6. Immunohistochemical staining of liver grafts with a monoclonal antibody against HCV-Envelope 2 for recurrent hepatitis C after living donor liver transplantation.
    Sadamori H, Yagi T, Iwagaki H, Matsuda H, Shinoura S, Umeda Y, Ohara N, Yanai H, Ogino T, Tanaka N. J Gastroenterol Hepatol. 2009;24(4):574-80.
  7. Preoperative assessment of the risk factors that help to predict the prognosis after living donor liver transplantation.
    Yoshida R, Iwamoto T, Yagi T, Sato D, Umeda Y, Mizuno K, Shinoura S, Matsukawa H, Matsuda H, Sadamori H, Tanaka N. World J Surg. 2008 Nov;32(11):2419-24.
  8. Effects of prophylactic splenic artery modulation on portal overperfusion and liver regeneration in small-for-size graft.
    Umeda Y, Yagi T, Sadamori H, Matsukawa H, Matsuda H, Shinoura S, Mizuno K, Yoshida R, Iwamoto T, Satoh D, Tanaka N. Transplantation. 2008 Sep 15;86(5):673-80.
  9. Successful re-transection of conglutinated hepatic resection plane for repeated systematized hepatectomy.
    Sadamori H, Yagi T, Matsukawa H, Matsuda H, Shinoura S, Umeda Y, Narushima M, Tanaka N. Hepatogastroenterology. 2008;55(82-83):363-6.
  10. The impact of donor age on the outcome of adult living donor liver transplantation.
    Iwamoto T, Yagi T, Umeda Y, Sato D, Matsukawa H, Matsuda H, Shinoura S, Sadamori H, Mizuno K, Yoshida R, Tanaka N. Transplantation. 2008 May 15;85(9):1240-5.
  11. The outcome of living donor liver transplantation with prior spontaneous large portasystemic shunts.
    Sadamori H, Yagi T, Matsukawa H, Matsuda H, Shinoura S, Umeda Y, Iwamoto T, Satoh D, Tanaka N. Transpl Int. 2008 Feb;21(2):156-62.
  12. Small liver graft regenerates through immediate increase of HGF and IL-6--possible involvement of sinusoidal tensile/shear stress in small liver graft.
    Oyama T, Sadamori H, Matsukawa H, Murata H, Umeda Y, Watanabe Y, Ozaki M, Iwagaki H, Tanaka N, Yagi T. Hepatogastroenterology. 2007;54(79):2078-83.
  13. Mechanism of impaired regeneration of fatty liver in mouse partial hepatectomy model.
    Murata H, Yagi T, Iwagaki H, Ogino T, Sadamori H, Matsukawa H, Umeda Y, Haga S, Takaka N, Ozaki M. J Gastroenterol Hepatol. 2007;22(12):2173-80.
  1. Preoperative proximal splenic artery embolization: a safe and efficacious portal decompression technique that improves the outcome of live donor liver transplantation.
    Umeda Y, Yagi T, Sadamori H, Matsukawa H, Matsuda H, Shinoura S, Iwamoto T, Satoh D, Iwagaki H, Tanaka N. Transpl Int. 2007;20(11):947-55.
  2. Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction.
    Takahashi HK, Iwagaki H, Yagi T, Kanke T, Liu K, Yoshino T, Tanaka N, Nishibori M. Clin Immunol. 2007;123(3):324-32.
  3. Effect of adenosine receptor subtypes stimulation on mixed lymphocyte reaction.
    Takahashi HK, Iwagaki H, Hamano R, Kanke T, Liu K, Sadamori H, Yagi T, Yoshino T, Sendo T, Tanaka N, Nishibori M. Eur J Pharmacol. 2007;564(1-3):204-10.
  4. Short-term high-dose followed by long-term low-dose hepatitis B immunoglobulin and lamivudine therapy prevented recurrent hepatitis B after liver transplantation.
    Takaki A, Yagi T, Iwasaki Y, Sadamori H, Matsukawa H, Matsuda H, Shinoura S, Umeda Y, Miyake Y, Terada R, Kobashi H, Sakaguchi K, Tanaka N, Shiratori Y. Transplantation. 2007;83(2):231-3.
  5. The immunosuppressive effects of nicotine during human mixed lymphocyte reaction.
    Takahashi HK, Iwagaki H, Hamano R, Kanke T, Liu K, Sadamori H, Yagi T, Yoshino T, Tanaka N, Nishibori M. Eur J Pharmacol. 2007 Mar 15;559(1):69-74.
  6. Ex vivo adenoviral gene transfer of constitutively activated STAT3 reduces post-transplant liver injury and promotes regeneration in a 20% rat partial liver transplant model.
    Huda KA, Guo L, Haga S, Murata H, Ogino T, Fukai M, Yagi T, Iwagaki H, Tanaka N, Ozaki M. Transpl Int. 2006;19(5):415-23.
  7. Complications of arterial reconstruction in living donor liver transplantation: a single-center experience.
    Matsuda H, Yagi T, Sadamori H, Matsukawa H, Shinoura S, Murata H, Umeda Y, Tanaka N. Surg Today. 2006;36(3):245-51.
  8. The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction.
    Katsuno G, Takahashi HK, Iwagaki H, Mizuno K, Yagi T, Mori S, Saito S, Yoshino T, Nishibori M, Tanaka N. Clin Immunol. 2006;119(1):110-9.
  9. Involvement of prostaglandin receptors (EPR2-4) in in vivo immunosuppression of PGE2 in rat skin transplant model.
    Fujimoto Y, Iwagaki H, Ozaki M, Ogino T, Murata H, Sun DS, Sadamori H, Takahashi HK, Tanaka N, Yagi T. Int Immunopharmacol. 2005;5(7-8):1131-9.
  10. Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction.
    Takahashi HK, Xue D, Iwagaki H, Tamura R, Katsuno G, Yagi T, Yoshino T, Mori S, Nishibori M, Tanaka N. Clin Immunol. 2005;115(1):85-92.
  11. Prolonged survival of donor-specific rat intestinal allograft by administration of bone-marrow-derived immature dendritic cells.
    Sheng Sun D, Iwagaki H, Ozaki M, Ogino T, Kusaka S, Fujimoto Y, Murata H, Sadamori H, Matsukawa H, Tanaka N, Yagi T. Transpl Immunol. 2005;14(1):17-20.
  12. Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction.
    Takahashi HK, Iwagaki H, Tamura R, Yagi T, Yoshino T, Mori S, Tanaka N, Nishibori M. J Pharmacol Sci. 2005;97(3):447-50.

 

遺伝子解析グループ

Publications
  1. Nagasaka T, Rhees J, Kloor M, Gebert J, Naomoto Y, Boland CR, Goel A. Somatic hypermethylation of MSH2 is a frequent event in Lynch Syndrome colorectal cancers. Cancer Res 2010;70:3098-108.
  2. Goel A, Nagasaka T, Hamelin R, Boland CR. An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers. PLoS One 2010;5:e9393.
  3. Goel A, Nguyen TP, Leung HC, Nagasaka T, Rhees J, Hotchkiss E, Arnold M, Banerji P, Koi M, Kwok CT, Packham D, Lipton L, Boland CR, Ward RL, Hitchins MP. De novo constitutional MLH1 epimutations confer early-onset colorectal cancer in two new  sporadic Lynch syndrome cases, with derivation of the epimutation on the paternal allele in one. Int J Cancer 2010.
  4. Ohara T, Takaoka M, Sakurama K, Nagaishi K, Takeda H, Shirakawa Y, Yamatsuji T, Nagasaka T, Matsuoka J, Tanaka N, Naomoto Y. The establishment of a new mouse model with orthotopic esophageal cancer showing the esophageal stricture. Cancer Lett 2010.
  5. Nagasaka T, Tanaka N, Cullings HM, Sun DS, Sasamoto H, Uchida T, Koi M, Nishida N, Naomoto Y, Boland CR, Matsubara N, Goel A. Analysis of fecal DNA methylation to detect gastrointestinal neoplasia. J Natl Cancer Inst 2009;101:1244-58.
  6. Vilkin A, Niv Y, Nagasaka T, Morgenstern S, Levi Z, Fireman Z, Fuerst F, Goel A, Boland CR. Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel. Cancer 2009;115:760-9.
  7. Nakagawa H, Nagasaka T, Cullings HM, Notohara K, Hoshijima N, Young J, Lynch HT, Tanaka N, Matsubara N. Efficient molecular screening of Lynch syndrome by specific 3' promoter methylation of the MLH1 or BRAF mutation in colorectal cancer with high-frequency microsatellite instability. Oncol Rep 2009;21:1577-83.
  8. Link A, Shin SK, Nagasaka T, Balaguer F, Koi M, Jung B, Boland CR, Goel A. JC Virus Mediates Invasion and Migration in Colorectal Metastasis. PLoS One 2009;4:e8146.
  9. Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology 2008;47:908-18.
  10. Navarro-Alvarez N, Soto-Gutierrez A, Yuasa T, Yamatsuji T, Shirakawa Y, Nagasaka T, Sun SD, Javed MS, Tanaka N, Kobayashi N. Long-term culture of Japanese human embryonic stem cells in feeder-free conditions. Cell Transplant 2008;17:27-33.
  11. Nagasaka T, Koi M, Kloor M, Gebert J, Vilkin A, Nishida N, Shin SK, Sasamoto H, Tanaka N, Matsubara N, Boland CR, Goel A. Mutations in both KRAS and BRAF may contribute to the methylator phenotype in colon cancer. Gastroenterology 2008;134:1950-60, 1960 e1.
  12. Nagasaka T, Goel A, Notohara K, Takahata T, Sasamoto H, Uchida T, Nishida N, Tanaka N, Boland CR, Matsubara N. Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis. Int J Cancer 2008;122:2429-36.
  13. Haugen AC, Goel A, Yamada K, Marra G, Nguyen TP, Nagasaka T, Kanazawa S, Koike J, Kikuchi Y, Zhong X, Arita M, Shibuya K, Oshimura M, Hemmi H, Boland CR, Koi M. Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. Cancer Res 2008;68:8465-72.
  14. Arnold CN, Nagasaka T, Goel A, Scharf I, Grabowski P, Sosnowski A, Schmitt-Graff A, Boland CR, Arnold R, Blum HE. Molecular characteristics and predictors of survival in patients with malignant neuroendocrine tumors. Int J Cancer 2008;123:1556-64.
  15. Shin SK, Nagasaka T, Jung BH, Matsubara N, Kim WH, Carethers JM, Boland CR, Goel A. Epigenetic and genetic alterations in Netrin-1 receptors UNC5C and DCC in human colon cancer. Gastroenterology 2007;133:1849-57.
  1. Nishida N, Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR. Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis. Cancer Res 2007;67:4586-94.
  2. Nishida N, Nagasaka T, Kashiwagi K, Boland CR, Goel A. High copy amplification of the Aurora-A gene is associated with chromosomal instability phenotype in human colorectal cancers. Cancer Biol Ther 2007;6:525-33.
  3. Matsumoto Y, Nagasaka T, Kambara T, Hoshizima N, Murakami J, Sasamoto H, Hosokawa M, Naomoto Y, Isozaki H, Shimizu K, Tanaka N, Matsubara N. Microsatellite instability and clinicopathological features in esophageal squamous cell cancer. Oncol Rep 2007;18:1123-7.
  4. Kimura K, Nagasaka T, Hoshizima N, Sasamoto H, Notohara K, Takeda M, Kominami K, Iishii T, Tanaka N, Matsubara N. No duplicate KRAS mutation is identified on the same allele in gastric or colorectal cancer cells with multiple KRAS mutations. J Int Med Res 2007;35:450-7.
  5. Goel A, Nagasaka T, Arnold CN, Inoue T, Hamilton C, Niedzwiecki D, Compton C, Mayer RJ, Goldberg R, Bertagnolli MM, Boland CR. The CpG island methylator phenotype and chromosomal instability are inversely correlated in sporadic colorectal cancer. Gastroenterology 2007;132:127-38.
  6. Ozaki K, Nagasaka T, Notohara K, Kambara T, Takeda M, Sasamoto H, Jass JR, Tanaka N, Matsubara N. Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis. Int J Cancer 2006;119:2513-9.
  7. Nagasaka T, Goel A, Matsubara N, Tanaka N. Detection of fecal DNA methylation for colorectal neoplasia: does it lead to an optimal screening test? Acta Med Okayama 2006;60:249-56.
  8. Goel A, Li MS, Nagasaka T, Shin SK, Fuerst F, Ricciardiello L, Wasserman L, Boland CR. Association of JC virus T-antigen expression with the methylator phenotype in sporadic colorectal cancers. Gastroenterology 2006;130:1950-61.
  9. Kimura N, Nagasaka T, Murakami J, Sasamoto H, Murakami M, Tanaka N, Matsubara N. Methylation profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients. Nucleic Acids Res 2005;33:e46.
  10. Yamamoto T, Nagasaka T, Notohara K, Sasamoto H, Murakami J, Tanaka N, Matsubara N. Methylation assay by nucleotide incorporation: a quantitative assay for regional CpG methylation density. Biotechniques 2004;36:846-50, 852, 854.
  11. Sasamoto H, Nagasaka T, Notohara K, Ozaki K, Isozaki H, Tanaka N, Matsubara N. Allele-specific methylation analysis on upstream promoter region of H19 by methylation-specific PCR with confronting two-pair primers. Int J Oncol 2004;25:1273-8.
  12. Nagasaka T, Sasamoto H, Notohara K, Cullings HM, Takeda M, Kimura K, Kambara T, MacPhee DG, Young J, Leggett BA, Jass JR, Tanaka N, Matsubara N. Colorectal cancer with mutation in BRAF, KRAS, and wild-type with respect to both oncogenes showing different patterns of DNA methylation. J Clin Oncol 2004;22:4584-94.
  13. Kambara T, Sharp GB, Nagasaka T, Takeda M, Sasamoto H, Nakagawa H, Isozaki H, MacPhee DG, Jass JR, Tanaka N, Matsubara N. Allelic loss of a common microsatellite marker MYCL1: a useful prognostic factor of poor outcomes in colorectal cancer. Clin Cancer Res 2004;10:1758-63.
  14. Nagasaka T, Sharp GB, Notohara K, Kambara T, Sasamoto H, Isozaki H, MacPhee DG, Jass JR, Tanaka N, Matsubara N. Hypermethylation of O6-methylguanine-DNA methyltransferase promoter may predict nonrecurrence after chemotherapy in colorectal cancer cases. Clin Cancer Res 2003;9:5306-12.
  15. Kambara T, Matsubara N, Nakagawa H, Notohara K, Nagasaka T, Yoshino T, Isozaki H, Sharp GB, Shimizu K, Jass J, Tanaka N. High frequency of low-level microsatellite instability in early colorectal cancer. Cancer Res 2001;61:7743-6.
  16. Chen L, Matsubara N, Yoshino T, Nagasaka T, Hoshizima N, Shirakawa Y, Naomoto Y, Isozaki H, Riabowol K, Tanaka N. Genetic alterations of candidate tumor suppressor ING1 in human esophageal squamous cell cancer. Cancer Res 2001;61:4345-9.

 

英文論文業績(2005〜2015)

2015年

  1. Takaki A, Yagi T, Yamamoto K:Safe and cost-effective control of post-transplantation recurrence of hepatitis B. Hepatol Res, 45(1):38-47, 2015
  2. Satoh D, Sadamori H, Yagi T, Fujiwara T:Enlarging lymphoepithelial cyst of the pancreas during 12 months of observation: report of a case. Surg Today, 45(1):101-104, 2015
  3. Sakakihara I, Kato H, Muro S, Noma Y, Yamamoto N, Harada R, Horiguchi S, Tsutsumi K, Okada H, Yamamoto K, Sadamori H, Yagi T:Double-balloon enteroscopy for choledochojejunal anastomotic stenosis after hepato-biliary-pancreatic operation. Digestive Endoscopy, 27(1):146-154, 2015
  4. Koike K, Takaki A, Yagi T, Iwasaki Y, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Miyake Y, Ikeda F, Shiraha H, Fujiwara T, Yamamoto K:Enhancement of Programmed Death Ligand 2 on Hepatitis C Virus Infected Hepatocytes by Calcineurin Inhibitors. Transplantation, 99(7):1447-1454, 2015
  5. Inada R, Nagasaka T, Toshima T, Mori Y, Kondo Y, Kishimoto H, Hiraki T, Oshiro T, Kanemitsu Y, Fujiwara T:Aggressive multimodality treatment for advanced rectal cancer. Acta Medica Okayama, 69(2):113-118, 2015
  6. Inada R, Sekine S, Taniguchi T, Tsuda H, Katai H, Fujiwara T, Kushima R:ARID1A expression in gastric adenocarcinoma: Clinicopathological significance and correlation with DNA mismatch repair status. World Journal of Gastroenterology, 21(7)          :2159-2168, 2015
  7. Shimoyama K, Kagawa S, Ishida M, Watanabe S, Noma K, Takehara K, Tazawa H, Hahimoto Y, Tanabe S, Matsuoka J, Kobayashi H, Fujiwara T:Viral transduction of the HER2-extracellular domain expands trastuzumab-based photoimmunotherapy for HER2 negative breast cancer cells. Breast Cancer Res Treat, 149(3):597-605, 2015
  8. Utsumi M,  Umeda Y, Takagi K, Kuise T,Yoshida R, Nobuoka D, Shinoura S, Sadamori H, Yagi T, Fujiwara T:Correlation of computed tomography imaging features and pathological features of 41 patients with pancreatic neuroendocrine tumors. Hepatogastroenterology, 62(138):441-446, 2015
  9. Mori Y, Nagasaka T, Mishima H, Umeda Y, Inada R, Kishimoto H, Goel A, Fujiwara T:The rare BRAF VK600-601E mutation as a possible indicator of poor prognosis in rectal carcinoma – a report of a case. BMC Med Genet, 16(1):10.1186/s12881-015-0144-7,  2015
  10. Shirakawa Y, Noma K, Koujima T, Maeda N, Tanabe S, Ohara T, Fujiwara T:Prone-position thoracoscopic resection of posterior mediastinal lymph node metastasis from rectal cancer. World J Surg Oncol,13(45):doi:10.1186/s12957-015-0466-0, 2015
  11. Yano S, Zhang Y, Zhao M, Hiroshima Y, Miwa S, Uehara F, Kishimoto H, Tazawa H, Bouvet M, Fujiwara T, Hoffman RM:Tumor-targeting salmonella typhimurium A1-R decoys quiescent cancer cells to cycle as visualized by FUCCI imaging and become sensitive to chemotherapy. Cell Cycle, 13(24):3958-3963, 2015
  12. Yamatsuji T, Fujiwara Y, Matsumoto H, Hato S, Namikawa T, Hanazaki K, Takaoka M, Hayashi J, Shigemitsu K, Yoshida K, Urakami A, Uno F, Nishizaki M, Kagawa S, Ninomiya M, Fujiwara T, Hirai T, Nakamura M, Haisa M, Naomoto Y:Feasibility of oral administration of S-1 as adjuvant chemotherapy in gastric cancer: 4-week S‑1 administration followed by 2-week rest vs. 2-week administration followed by 1-week rest. Mol Clin Oncol, 3(3):527-532, 2015
  13. Toda K, Nagasaka T, Umeda Y, Tanaka T, Kawai T, Fuji T, Taniguchi F, Yasui K, Kubota N, Takehara Y, Tazawa H, Kagawa S, Sun DS, Nishida N, Goel A, Fujiwara T:Genetic and epigenetic alterations of netrin-1 receptors in gastric cancer with chromosomal instability. Clin Epigenetics, doi:10.1186/s13148-015-0096-y, 2015
  14. Shirakawa Y, Noma K, Koujima T, Maeda N, Tanabe S, Ohara T, Sakurama K, Fujiwara T:Operative technique of antethoracic esophageal reconstruction with pedicled jejunal flap. Esophagus, 12(1):57-64, 2015
  15. Shigeyasu K, Nagasaka T, Mori Y, Yokomichi N, Kawai T, Fuji T, Kimura K, Umeda Y, Kagawa S, Goel A, Fujiwara T:Clinical Significance of MLH1 Methylation and CpG Island Methylator Phenotype as Prognostic Markers in Patients with Gastric Cancer. PLoS One, 10(6):e0130409, 2015
  16. Yano S, Miwa S, Kishimoto H, Uehara F, Tazawa H, Toneri M, Hiroshima Y, Yamamoto M, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM: Targeting tumors with a killer-reporter adenovirus for curative fluorescence-guided surgery of soft-tissue sarcoma. Oncotarget, 6(15):13133-13148, 2015
  17. Miwa S, Yano S, Kimura H, Yamamoto M, Toneri M, Murakami T, Hayashi K, Yamamoto N, Fujiwara T, Tsuchiya H, Hoffman RM:Heterogeneous cell-cycle behavior in response to UVB irradiation by a population of single cancer cells visualized by time-lapse FUCCI imaging. Cell Cycle, 14(12):1932-1937, 2015
  18. Yano S, Miwa S, Kishimoto H, Toneri M, Hiroshima Y, Yamamoto M, Bouvet M, Urata Y, Tazawa H, Kagawa S, Fujiwara T, Hoffman RM:Experimental Curative Fluorescence-guided Surgery of Highly Invasive Glioblastoma Multiforme Selectively Labeled With a Killer-reporter Adenovirus. Mol Ther, 23(7):1182-1188, 2015
  19. Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Kishimoto H, Tazawa H, Zhao M, Bouvet M, Fujiwara T, Hoffman RM:Cancer cells mimic in vivo spatial-temporal cell-cycle phase distribution and chemosensitivity in 3-dimensional Gelfoam® histoculture but not 2-dimensional culture as visualized with real-time FUCCI imaging. Cell Cycle, 14(6):808-819, 2015
  20. Miwa S, Yano S, Kimura H, Yamamoto M, Toneri M, Matsumoto Y, Uehara F, Hiroshima Y, Murakami T, Hayashi K, Yamamoto N, Bouvet M, Fujiwara T, Tsuchiya H, Hoffman RM:Cell-cycle fate-monitoring distinguishes individual chemosensitive and chemoresistant cancer cells in drug-treated heterogeneous populations demonstrated by real-time FUCCI imaging. Cell Cycle, 14(4):621-629, 2015
  21. Matsui Y, Hiraki T, Gobara H, Iguchi T, Fujiwara H, Nagasaka T, Toyooka S, Kanazawa S :Long-term survival following percutaneous radiofrequency ablation of colorectal lung metastases. J Vasc Interv Radiol,26(3):303-310, 2015
  22. Takaki A, Yasunaka T, Yagi T:Molecular Mechanisms to Control Post-Transplantation Hepatitis B Recurrence. Int J Mol Sci, 16(8):17494-17513, 2015
  23. Kanamitsu K, Washio K, Oda M, Noda T, Oyama T, Tanimoto T, Tanaka T, Ida K, Shimada A:Suspected early onset of congenital Langerhans cell histiocytosis involving ectopic cervical thymus and mediastinal thymus, simultaneously. Pediatr Blood Cancer, 62(8):1491-1492, 2015
  24. Yano S, Hiroshima Y, Maawy A, Kishimoto H, Suetsugu A, Miwa S, Toneri M, Yamamoto M, Katz MH, Fleming JB, Urata Y, Tazawa H, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM:Color-coding cancer and stromal cells with genetic reporters in a patient-derived orthotopic xenograft (PDOX) model of pancreatic cancer enhances fluorescence-guided surgery. Cancer Gene Therapy, 22(7):344-350, 2015
  25. Yano S, Zhang Y, Miwa S, Kishimoto H, Urata Y, Bouvet M, Kagawa S, Fujiwara T, Hoffman RM :Precise navigation surgery of tumours in the lung in mouse models enabled by in situ fluorescence labelling with a killer-reporter adenovirus. BMJ Open Respir Res, :doi: 10.1136/bmjresp-2015-000096, 2015
  26. Yano S, Miwa S, Kishimoto H, Urata Y, Tazawa H, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM:Eradication of osteosarcoma by fluorescence-guided surgery with tumor labeling by a killer-reporter adenovirus. J Orthop Res, :doi: 10.1002/jor.23073, 2015
  27. Shirakawa Y, Noma K, Ohara T, Kashima H, Maeda N, Tanabe S, Kagawa S, Fujiwara T:Prone-position thoracoscopic ligation of the thoracic duct for chyle leak following radical neck dissection in a patient with a right aortic arch. Acta Medica Okayama, 69(3):173-176, 2015
  28. Takehara K, Tazawa H, Okada N, Hashimoto Y, Kikuchi S, Kuroda S, Kishimoto H, Shirakawa Y, Narii N, Mizuguchi H, Urata Y, Kagawa S, Fujiwara T:Targeted Photodynamic Virotherapy Armed with a Genetically Encoded Photosensitizer. Mol Cancer Ther, DOI: 10.1158/1535-7163, 2015
  29. Terao M, Takaki A, Maruyama T, Oe H, Yasunaka T, Tamaki N, Nakamura K, Tomofuji T, Yagi T, Sadamori H, Umeda Y, Shinoura S, Yoshida R, Nouso K, Ekuni D, Koike K, Ikeda F, Shiraha H, Morita M, Ito H, Fujiwara T, Yamamoto K:Serum Oxidative/anti-oxidative Stress Balance Is Dysregulated in Potentially Pulmonary Hypertensive Patients with Liver Cirrhosis: A Case Control study. Intern Med, 54(22):2815-2826, 2015
  30. Iwamoto T, Kelly C, Mizoo T, Nogami T, Motoki T, Shien T, Taira N, Hayashi N, Niikura N, Fujiwara T, Doihara H, Matsuoka J:Relative Prognostic and Predictive Value of Gene Signature and Histologic Grade in Estrogen Receptor–Positive, HER2-Negative Breast Cancer. Clin Breast Cancer,  doi: 10.1016/j.clbc.2015.10.004, 2015
  31. Sugiu K, Iwamoto T, Kelly CM, Watanabe N, Motoki T, Itoh M, Ohtani S, Higaki K, Imada T, Yuasa T, Omori M, Sonobe H, Fujiwara T, Matsuoka J :Neoadjuvant Chemotherapy with or without Concurrent Hormone Therapy in Estrogen Receptor-Positive Breast Cancer:NACED-Randomized Multicenter Phase II Trial. Acta Medica Okayama, 69(5):291-299, 2015
  32. Inada R, Nagasaka T, Kondo Y, Watanabe A, Toshima T, Kubota N, Kikuchi S, Ishida M, Kuroda S, Mori Y, Kishimoto H, Fujiwara T:A Case-matched Comparative Study of Laparoscopic and Open Total Proctocolectomy for Ulcerative Colitis. Acta Medica Okayama, 69(5):267-273, 2015
  33. Tazawa H, Nagasaka T, Kagawa S, Fujiwara T:MicroRNA as a molecular target for gastrointestinal cancers. Transl Gastrointest Cancer, 4(3):219-235, 2015
  34. Wada S, Matsushita Y, Tazawa H, Aoi W, Naito Y, Higashi A, Ohshima H, Yoshikawa T:Loss of p53 in stromal fibroblasts enhances tumor cell proliferation through nitric-oxide-mediated cyclooxygenase 2 activation. Free Radic Res, 49(3):269-278, 2015
  35. Callari M, Cappelletti V, D'Aiuto F, Musella V, Lembo A, Petel F, Karn T, Iwamoto T, Provero P, Daidone MG, Gianni L, Bianchini G:Subtype specific metagene-based prediction of outcome after neoadjuvant and adjuvant treatment in breast cancer. Clin Cancer Res, :doi:10.1158/1078-0432.CCR-15-0757,  2015
  36. Kondo T, Hayashi N, Ohde S, Suzuki K, Yoshida A, Yagata H, Niikura N, Iwamoto T, Kida K, Murai M, Takahashi Y, Tsunoda H, Nakamura S, Yamauchi H : A model to predict upstaging to invasive carcinoma in patients preoperatively diagnosed with ductal carcinoma in situ of the breast. J Surg Oncol, 112(5):476-480, 2015
  37. Kinoshita T, Fukui N, Anan K, Iwamoto T, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y:Comprehensive prognostic report of the Japanese Breast Cancer Society Registry in 2004. Breast Cancer,
    DOI 10.1007/s12282-015-0644-5, 2015
  38. Anan K, Fukui N, Kinoshita T, Iwamoto T, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y:Comprehensive prognostic report of the Japanese Breast Cancer Society Registry in 2005. Breast Cancer,
    DOI 10.1007/s12282-015-0645-4, 2015
  39. Iwamoto T, Fukui N, Kinoshita T, Anan K, Niikura N, Kawai M, Hayashi N, Tsugawa K, Aogi K, Ishida T, Masuoka H, Masuda S, Iijima K, Nakamura S, Tokuda Y:Comprehensive prognostic report of the Japanese Breast Cancer Society registry in 2006. Breast Cancer,
    DOI 10.1007/s12282-015-0646-3, 2015
  40. Yano S, Takehara K, Kishimoto H, Urata Y, Kagawa S, Bouvet M, Fujiwara T, Hoffman RM: Adenoviral targeting of malignant melanoma for fluorescence-guided surgery prevents recurrence in orthotopic nude-mouse models. Oncotarget, doi: 10.18632/oncotarget.6670, 2015
  41. Fujiwara T, Kagawa S, Tazawa H:Multidisciplinary Cancer Therapy with Telomerase-Specific Oncolytic Adenovirus. Current Cancer Therapy Reviews,11(3):178-187, 2015
  42. Kuwada K, Kuroda S, Kikuchi S, Hori N, Kubota T, Nishizaki M, Kagawa S, Fujiwara T: Strategic approach to concurrent aberrant left gastric vein and aberrant left hepatic artery in laparoscopic distal gastrectomy for early gastric cancer: A case report. Asian J Endosc Surg, 8(4):454-456, 2015
  43. Niikura N, Hashimoto J, Kazama T, Koizumi J, Ogiya R, Terao M, Oshitanai R, Morioka T, Tsuda B, Okamura T, Saito Y, Iwaisako K, Iwamoto T, Hayashi N, Imai Y, Tokuda Y: Diagnostic performance of F-fluorodeoxyglucose PET/CT and bone scintigraphy in breast cancer patients with suspected bone metastasis. Breast cancer, DOI 10.1007/s12282-015-0621-z, 2015
  44. Inagaki Y, Oshiro Y, Tanaka T, Yoshizumi T, Okajima H, Ishiyama K, Nakanishi C, Hidaka M, Wada H, Hibi T, Takagi K, Honda M, Kuramitsu K, Tanaka H, Tohyama T, Ikegami T, Imura S, Shimamura T, Nakayama Y, Urahashi T, Yamagishi K, Ohnishi H, Nagashima S, Takahashi M, Shirabe K, Kokudo N, Okamoto H, Ohkohchi N:A Nationwide Survey of Hepatitis E Virus Infection and Chronic Hepatitis E in Liver Transplant Recipients in Japan. EBioMedicine, 2(11):1607-1612, 2015
  45. Shibata M, Matsusaki T, Kaku R, Umeda Y, Yagi T, Morimatsu H:Intraoperative Oxygen Consumption During Liver Transplantation. Transplant Proc, 47(10):2902-2906, 2015

2014年

  1. Kikuchi S, Kishimoto H, Tazawa H, Hashimoto Y, Kuroda S, Nishizaki M, Nagasaka T, Shirakawa Y, Kagawa S, Urata Y, Hoffman RM, Fujiwara T:Biological Ablation of Sentinel Lymph Node Metastasis in Submucosally Invaded Early Gastrointestinal Cancer. Mol Ther, doi: 10.1038/mt.2014.244, 2014
  2. Kuise T, Noguchi H, Tazawa H, Kawai T, Iwamuro M, Saitoh I, Kataoka H, Watanabe M, Noguchi Y, Fujiwara T:Establishment of a pancreatic stem cell line from fibroblast-derived induced pluripotent stem cells. BioMedical Engineering OnLine, 13:64, doi:10.1186/1475-925X-13-64, 2014
  3. Nakamura K, Joja I, Nagasaka T, Haruma T, Hiramatsu Y:Maximum standardized lymph node uptake value could be an important predictor of recurrence and survival in patients with cervical cancer. Eur J Obstet Gynecol Reprod Biol, 173:77-82, 2014
  4. Link A, Balaguer F, Nagasaka T, Boland CR, Goel A:MicroRNA miR-J1-5p as a potential Biomarker for JC Virus Infection in the Gastrointestinal Tract. PLoS One, DOI: 10.1371/journal.pone.0100036, 2014
  5. Kondo Y, Nagasaka T, Kobayashi S, Kobayashi N, Fujiwara T:Management of peritoneal effusion by sealing with a self-assembling nanofiber polypeptide following pelvic surgery. Hepatogastroenterology, 61(130):349-353, 2014
  6. Shigeyasu K, Tazawa H, Hashimoto Y, Mori Y, Nishizaki M, Kishimoto H, Nagasaka T, Kuroda S, Urata Y, Goel A, Kagawa S, Fujiwara T:Fluorescence virus-guided capturing system of human colorectal circulating tumour cells for non-invasive companion diagnostics. Gut, doi: 10.1136/gutjnl-2014-306957, 2014
  7. Eto K, Nishimura W, Oishi H, Udagawa H, Kawaguchi M, Hiramoto M, Fujiwara T, Takahashi S, Yasuda K:MafA is required for postnatal proliferation of pancreatic β-cells. PLoS One, 9(8):e104184, 2014
  8. Shirakawa Y, Noma K, Maeda N, Katsube R, Tanabe S, Ohara T, Sakurama K, Fujiwara T:Assistant-based standardization of prone position thoracoscopic esophagectomy. Acta Medica Okayama, 68(2):111-117, 2014
  9. Kuroda S, Kubota T, Aoyama K, Kikuchi S, Tazawa H, Nishizaki M, Kagawa S, Fujiwara T:Establishment of a Non-invasive Semi-Quantitative Bioluminescent Imaging Method for Monitoring of an Orthotopic Esophageal Cancer Mouse Model. PLoS One, 9(12): e114562, 2014
  10. Inada R, Yamamoto S, Oshiro T, Takawa M, Fujita S, Akasu T:A case-matched comparison of the short-term outcomes between laparoscopic and open abdominoperineal resection for rectal cancer. Surgery Today, 44:640-645, 2014
  11. Inada R, Yamamoto S, Takawa M, Fujita S, Akasu T:Laparoscopic resection of synchronous colorectal cancers in separate specimens. Asian J Endosc Surg, 7:227-231, 2014
  12. Tsutsumi K, Kato H, Okada H, Yagi T, Yamamoto K:Transplanted liver graft ischemia caused by pediatric ERCP in the prone position. Endoscopy, DOI: 10.1055/s-0034-1390732, 2014
  13. Tsuzakia R, Takakia A, Yagi T, Ikeda F, Koike K, Iwasaki Y, Shiraha H, Miyake Y, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Utsumi M, Nakayama E, Fujiwara T, Yamamoto K:Hepatitis C virus-specific t-cell response correlates with hepatitis activity and donor IL28B genotype early after liver transplantation. Acta Medica Okayama, 68(5):291-302, 2014
  14. Takaki A, Yagi T, Yamamoto K:Contradictory immune response in post liver transplantation hepatitis B and C. International Journal of Inflammation, doi: 10.1155/2014/814760, 2014
  15. Utsumi M, Takaki A, Umeda Y, Koike K, Napier SC, Watanabe N, Sadamori H, Shinoura S, Yoshida R, Nobuoka D, Yasunaka T, Nakayama E, Yamamoto K, Fujiwara T, Yagi T:Frequency of regulatory T-cell and hepatitis C viral antigen-specific immune response in recurrent hepatitis C after liver transplantation. Transplant Immunology, 31(1):33-41, 2014
  16. Uchida D, Shiraha H, Kato H, Nagahara T, Iwamuro M, Kataoka J, Horiguchi S, Watanabe M, Takaki A, Nouso K, Nasu Y, Yagi T, Kumon H, Yamamoto K:Potential of adenovirus-mediated REIC/Dkk-3 gene therapy for use in the treatment of pancreatic cancer. Journal of Gastroenterology and Hepatology, 29(5):973-983, 2014
  17. Yano S, Miwa S, Mii S, Hiroshima Y, Uehara F, Yamamoto M, Kishimoto H, Tazawa H, Fujiwara T, Hoffman RM:Invading cancer cells are predominantly in G 0/G 1 resulting in chemoresistance demonstrated by real-time FUCCI imaging. Cell Cycle, 13(6):953-960, 2014
  18. Itoh M, Iwamoto T, Matsuoka J, Nogami, T, Motoki T, Shien T, Taira N, Niikura N, Hayashi N, Ohtani S, Higaki K, Fujiwara T, Doihara H, Symmans WF, Pusztai L:Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers. Breast Cancer Res Treat, 143:403-409, 2014
  19. Yano S, Zhang Y, Miwa S, Tome Y, Hiroshima Y, Uehara F, Yamamoto M, Suetsugu A, Kishimoto H, Tazawa H, Zhao M, Bouvet M, Fujiwara T, Hoffman RM:Spatial-temporal FUCCI imaging of each cell in a tumor demonstrates locational dependence of cell cycle dynamics and chemoresponsiveness. Cell Cycle, 13(13):2110-2119, 2014
  20. Yano S, Li S, Han Q, Tan Y, Bouvet M, Fujiwara T, Hoffman RM:Selective  methioninase-induced trap of cancer cells in S/G2 phase visualized by FUCCI imaging confers chemosensitivity. Oncotarget, 5(18):8729-8736, 2014
  21. Utsumi M, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Nobuoka D, Takagi K, Fujiwara T, Yagi T:Risk factors of morbidity and predictors of long-term survival after hepatopancreatoduodenectomy for biliary cancer. Hepatogastroenterology, 61(136):2167-2172, 2014
  22. Kanda Y, Kawaguchi T, Kuramitsu Y, Kitagawa T, Kobayashi T, Takahashi N, Tazawa H, Habelhah H, Hamada JI, Kobayashi M, Hirahata M, Onuma K, Osaki M, Nakamura K, Kitagawa T, Hosokawa M, Okada F:Fascin regulates chronic inflammation-related human colon carcinogenesis by inhibiting cell anoikis. Proteomics, 14(9):1031-1041, 2014
  23. Nobuoka D, Fuji T, Yoshida K, Takagi K, Kuise T, Utsumi M, Yoshida R, Umeda Y, Shinoura S, Takeda Y, Ohtsuka A:Surgical education using a multi-viewpoint and multi-layer three-dimensional atlas of surgical anatomy (with video). Journal of Hepato-Biliary Pancreatic Sciences, 21(8):556-561, 2014
  24. Yabusaki M, Sato J, Kohyama A, Kojima T, Nobuoka D, Yoshikawa T, Sawada Y, Murakami K, Gohda K, Okegawa T, Nakamura M, Takamatsu K, Ito M, Kaneko K, Nakatsura T:Detection and preliminary evaluation of circulating tumor cells in the peripheral lood of patients with eight types of cancer using a telomerase-specific adenovirus. Oncology Reports, 32(5):1772-1778, 2014
  25. Yagi T, Nobuoka D, Shinoura S, Umeda Y, Sato D, Yoshida R, Utsumi M, Fuji T, Sadamori H, Fujiwara T:First successful case of simultaneous liver and kidney transplantation for patients with chronic liver and renal failure in Japan. Hepatology Research, 44(3): 358-363, 2014
  26. Niikura N, Sakatani T, Arima N, Ohi Y, Honma N, Kanomata N, Yoshida K, Kadoya T, Tamaki K, Kumaki N, Iwamoto T, Sugie T, Moriya T:Assessment of the Ki67 labeling index: a Japanese validation ring study. Breast Cancer, DOI 10.1007/s12282-014-0536-0, 2014
  27. Niikura N, Masuda S, Kumaki N, Xiaoyan T, Terada M, Terao M, Iwamoto T, Oshitanai R, Morioka T, Tuda B, Okamura T, Saito Y, Suzuki Y, Tokuda Y:Prognostic significance of the ki67 scoring categories in breast cancer subgroups. Clin Breast Cancer, 14(5): 323-329, 2014
  28. Gyorffy B, Bottai G, Lehmann-Che J, Keri G, Orfi L, Iwamoto T, Desmedt C, Bianchini G, Turner NC, de The H, Andre F, Sotiriou C, Hortobagyi GN, Di Leo A, Pusztai L, Santarpia L:TP53 mutation-correlated genes predict the risk of tumor relapse and identify MPS1 as a potential therapeutic kinase in TP53-mutated breast cancers. Mol Oncol, 8(3): 508-519, 2014
  29. Bertucci F, Ueno NT, Finetti P, Vermeulen P, Lucci A, Robertson FM, Marsan M, Iwamoto T, Krishnamurthy S, Masuda H, Van Dam P, Woodward WA, Cristofanilli M, Reuben JM, Dirix L, Viens P, Symmans WF, Birnbaum D, Van Laere SJ:Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival. Ann Oncol, 25(2): 358-365, 2014
  30. Kai K, Iwamoto T, Kobayashi T, Arima Y, Takamoto Y, Ohnishi N, Bartholomeusz C, Horii R, Akiyama F, Hortobagyi GN, Pusztai L, Saya H, Ueno NT:Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells. Oncogene, 33(4): 440-448, 2014
  31. Masuda H, Brewer TM, Liu DD, Iwamoto T, Shen Y, Hsu L, Willey JS, Gonzalez-Angulo AM, Chavez-MacGregor M, Fouad TM, Woodward WA, Reuben JM, Valero V, Alvarez RH, Hortobagyi GN, Ueno NT:Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes. Ann Oncol, 25(2): 384-391, 2014
  32. Inada R, Nagasaka T, Toshima T, Mori Y, Kondo Y, Kishimoto H, Fujiwara T:Intussusception due to rectal adenocarcinoma in a young adult: A case report. World J Gastroenterol, 20(35):12678-12681, 2014
  33. Shigeyasu K, Tanakaya K, Nagasaka T, Aoki H, Fujiwara T, Sugano K, Ishikawa H, Yoshida T, Moriya Y, Furukawa Y, Goel A, Takeuchi H:Early detection of metachronous bile duct cancer in Lynch syndrome: report of a case. Surg Today, 44(10): 1975-1981, 2014
  34. Kagawa S, Shigeyasu K, Ishida M, Watanabe M, Tazawa H, Nagasaka T, Shirakawa Y, Fujiwara T:Molecular diagnosis and therapy for occult peritoneal metastasis in gastric cancer patients. World J Gastroenterol, 20(47):17796-17803, 2014
  35. Itokawa F, Kamisawa T, Nakano T, Itoi T, Ha mada Y, Ando H, Fujii H, Koshinaga T, Yoshida H, Tamoto E, Noda T, Kimura Y, Maguchi J, Urushihara N, Horaguchi J, Morotomi Y, Sato M, Hanada K, Tanaka M, Takahashi A, Yamaguchi T, Arai Y, Horiguchi A, Igarashi Y, Inui K:Exploring the length of the common channel of pancreaticobiliary maljunction on magnetic resonance cholangiopancreatography. J Hepatobiliary Pancreat Sci, DOI:10.1002/jhbp.168, 2014
  36. Kuroda S, Tam J, Roth JA, Sokolov K, Ramesh R:EGFR-targeted plasmonic magnetic nanoparticles suppress lung tumor growth by abrogating G2/M cell-cycle arrest and inducing DNA damage.  Int J Nanomedicine, 9:3825-3839, 2014

2013年

  1. Sadamori H, Umeda Y, Yagi T, Fujiwara T:The Modulation of Portal Venous Hemodynamics in Living Donor Liver.Hemodynamics: Monitoring, Theory and Applications(Senzaki H),pp217-229,Nova science publishers, Inc. New York, 2013(著書)
  2. Kagawa S, Fujiwara T:Gene therapy for cancer treatment.Gene Therapy: Technologies & Applications(Morishita R,  Nakagami H,), pp70-83, Future Medicine Ltd, London, 2013(著書)
  3. Kuroda S, Kagawa S, Fujiwara T:Selectively replicating oncolytic adenoviruses combined with chemotherapy, radiotherapy, or molecular targeted therapy for treatment of human cancers. Gene Therapy of Cancer, 3rd Edition (Lattime, E. C., Gerson, S. L., ed.), pp171-183, Academic Press, 2013(著書)
  4. Tazawa H, Kagawa S, Fujiwara T:Application of cancer gene therapy using tumor suppressor gene p53. Tumor Suppressor Genes: Functions, Regulation and Health Effects (Gunduz M, Gunduz E), pp81-103, Nova science publishers, Inc., New York, 2013(著書)
  5. Sadamori H, Yagi T, Shinoura S, Umeda Y, Yoshida R, Satoh D, Nobuoka D, Utsumi M, Yoshida K, Fujiwara T:Bloodless donor hepatectomy in living donor liver transplantation: counterclockwise liver rotation and early hanging maneuver.J Gastrointest Surg,17(1):203-206, 2013
  6. Sadamori H, Yagi T, Shinoura S, Umeda Y, Yoshida R, Satoh D, Nobuoka D, Utsumi M, Fujiwara T:New surgical approach to large splenorenal shunt in living donor liver transplantation: diversion of SMV and SPV blood flow. J Gastrointest Surg,17(2):403-407, 2013
  7. Sasaki T, Tazawa H, Hasei J, Osaki S, Kunisada T, Yoshida A, Hashimoto Y, Yano S, Yoshida R, Kagawa S, Uno F, Urata Y, Ozaki T, Fujiwara T:    A simple detection system for adenovirus receptor expression using a telomerase-specific replication-competent adenovirus.  Gene Ther,20(1):112-118, 2013
  8. Sadamori H, Yagi T, Shinoura S, Umeda Y, Yoshida R, Satoh D, Nobuoka D, Utsumi M, Fujiwara T:Risk factors for major morbidity after liver resection for hepatocellular carcinoma. Br J Surg,100(1):122-129, 2013
  9. Sadamori H, Yagi T, Shinoura S, Umeda Y, Yoshida R, Satoh D, Nobuoka D, Utsumi M, Yoshida K, Fujiwara T:Risk factors for organ/space surgical site infection after hepatectomy for hepatocellular carcinoma in 359 recent cases.J Hepatobiliary Pancreat Sci,20(2):186-196, 2013
  10. Umeda Y, Nagasaka T, Mori Y, Sadamori H, Sun DS, Shinoura S, Yoshida R, Satoh D, Nobuoka D, Utsumi M, Yoshida K, Yagi T, Fujiwara T:Poor prognosis of KRAS or BRAF mutant colorectal liver metastasis without microsatellite instability.J Hepatobiliary Pancreat Sci,20(2):223-233, 2013
  11. Kohka Takahashi H, Sadamori H, Liu K, Wake H, Mori S, Yoshino T, Yamamoto Y, Yamamoto H, Nishibori M:Role of cell-cell interactions in high mobility group box 1 cytokine activity in human peripheral blood mononuclear cells and mouse splenocytes.Eur J Pharmacol,701:194–202, 2013
  12. Bao XH, Takaoka M, Hao HF, Fukazawa T, Yamatsuji T, Sakurama K, Takigawa N, Nakajima M, Fujiwara T, Naomoto Y:  Antiproliferative effect of the HSP90 inhibitor NVP-AUY922 is determined by the expression of PTEN in esophageal cancer.Oncol Rep,29(1):45-50, 2013
  13. Shigeyasu K, Kagawa S, Uno F, Nishizaki M, Kishimoto H, Gochi A, Kimura T, Takahata T, Nonaka Y, Ninomiya M, Fujiwara T:Multicenter phase II study of S-1 and docetaxel combination chemotherapy for advanced or recurrent gastric cancer patients with peritoneal dissemination.Cancer Chemother Pharmacol,71(4):937-943, 2013
  14. Nishikawa T, Takaoka M, Ohara T, Tomono Y, Hao H, Bao X, Fukazawa T, Wang Z, Sakurama K, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Tanaka N, Fujiwara T, Naomoto Y:Antiproliferative effect of a novel mTOR inhibitor temsirolimus contributes to the prolonged survival of orthotopic esophageal cancer-bearing mice.Cancer Biol Ther,14(3):230-236, 2013
  15. Hasei J, Sasaki T, Tazawa H, Osaki S, Yamakawa Y, Kunisada T, Yoshida A, Hashimoto Y, Onishi T, Uno F, Kagawa S, Urata Y, Ozaki T, Fujiwara T:Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells.Mol Cancer Ther,12(3):314-325, 2013
  16. Nobuoka D, Yoshikawa T, Takahashi M, Iwama T, Horie K, Shimomura M, Suzuki S, Sakemura N, Nakatsugawa M, Sadamori H, Yagi T, Fujiwara T, Nakatsura T:Intratumoral peptide injection enhances tumor cell antigenicity recognized by cytotoxic T lymphocytes: a potential option for improvement in antigen-specific cancer immunother.Cancer Immunol Immunother,62(4):639-652, 2013
  17. Ohara T, Noma K, Urano S, Watanabe S, Nishitani S, Tomono Y, Kimura F, Kagawa S, Shirakawa Y, Fujiwara T:A novel synergistic effect of iron depletion on antiangiogenic cancer therapy.Int J Cancer,132(11):2705-2713, 2013
  18. Yagi T, Nobuoka D, Shinoura S, Umeda Y, Sato D, Yoshida R, Utsumi M, Fuji T, Sadamori H, Fujiwara T:First successful case of simultaneous liver and kidney  transplantation for patients with chronic liver and renal  failure in Japan.Hepatol Res,2013
  19. Utsumi M, Umeda Y, Sadamori H, Nagasaka T, Takaki A, Matsuda H, Shinoura S, Yoshida R, Nobuoka D, Satoh D, Fuji T, Yagi T, Fujiwara T:Risk factors for acute renal injury in living donor liver transplantation: evaluation of the RIFLE criteria.Transpl Int,26(8):842-852, 2013
  20. Satoh D, Yagi T, Nagasaka T, Shinoura S, Umeda Y, Yoshida R, Utsumi M, Tanaka T, Sadamori H, Fujiwara T:CD14 upregulation as a distinct feature of non-alcoholic fatty liver disease after pancreatoduodenectomy.World J Hepatol,5(4):189-195, 2013
  21. Takaki A, Yagi T, Yasunaka T, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Yasuda Y, Nakayama E, Miyake Y, Ikeda F, Shiraha H, Nouso K, Fujiwara T, Yamamoto K:Which patients respond best to hepatitis B vaccination after a hepatitis B virus-related liver transplantation? J Gastroenterol,[Epub ahead of print], 2013
  22. Nobuoka D, Yoshikawa T, Fujiwara T, Nakatsura T:Peptide intra-tumor injection for cancer immunotherapy: Enhancement of tumor cell antigenicity is a novel and attractive strategy.Hum Vaccin Immunother,9(6):1234-1236, 2013
  23. Sadamori H, Yagi T, Shigeyasu K, Umeda Y, Sugihara M, Yokomichi N, Ohara T, Nishida N, Nagasaka T, Goel A, Fujiwara T:Advanced hepatocellular carcinoma with lymph node metastases showing epithelial to mesenchymal transition effectively treated with systemic chemotherapy: Report of a case.Hepatol Res,[Epub ahead of print], 2013
  24. Tanabe S, Shirakawa Y, Takehara Y, Maeda N, Katsube R, Ohara T, Sakurama K, Noma K, Fujiwara T:Successfully treated pneumatosis cystoides intestinalis with pneumoperitoneum onset in a patient administered α-glucosidase inhibitor.Acta Med Okayama,67(2):123-128, 2013
  25. Sadamori H, Yagi T, Shinoura S, Umeda Y, Yoshida R, Sato D, Nobuoka D, Utsumi M, Fujiwara T:Living donor liver transplantation to a survivor of liver resection for hepatocellular carcinoma with major portal vein invasion. Acta Med Okayama,67(2):117-121, 2013
  26. Alafate A, Shinya T, Okumura Y, Sato S, Hiraki T, Ishii H, Gobara H, Kato K, Fujiwara T, Miyoshi S, Kaji M, Kanazawa S:The Maximum standardized uptake value is more reliable than size measurement in early follow-up to evaluate potential pulmonary malignancies following radiofrequency ablation.Acta Med Okayama,67(2):105-112, 2013
  27. Li G.D, Kawashima H, Ogose A, Ariizumi T, Hotta T, Kuwano R, Urata Y, Fujiwara T, Endo N:Telomelysin shows potent antitumor activity through apoptotic and non-apoptotic cell death in soft tissue sarcoma cells.Cancer Sci,104(9):1178-1188, 2013
  28. Tazawa H, Kagawa S, Fujiwara T:Advances in adenovirus-mediated p53 cancer gene therapy.Expert Opin Biol Ther,13(11):1569-1583, 2013
  29. Yano S, Tazawa H, Hashimoto Y, Shirakawa Y, Kuroda S, Nishizaki M, Kishimoto H, Uno F, Nagasaka T, Urata Y, Kagawa S, Hoffman RM, Fujiwara T:A genetically engineered oncolytic adenovirus decoys and lethally traps quiescent cancer stem-like cells into S/G2/M-phases.Clin Cancer Res,19(23):6495-6505, 2013
  30. Sato D, Kurihara Y, Kondo S, Shirota T, Urata Y, Fujiwara T, Shintani S :Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines.Oncol Rep,     [Epub ahead of print], 2013
  31. Nishimura W, Eto K, Miki A, Goto M, Kawaguchi M, Nammo T, Udagawa H, Hiramoto M, Shimizu Y, Okamura T, Fujiwara T, Yasuda Y, Yasuda K:Quantitative Assessment of Pdx1 Promoter Activity in Vivo Using a Secreted Luciferase Reporter System.Endocrinology,154(11):4388-4395, 2013
  32. Shigeyasu K, Tanakaya K, Nagasaka T, Aoki H, Fujiwara T, Sugano K, Ishikawa H, Yoshida T, Moriya Y, Furukawa Y, Goel A, Takeuchi H:Early detection of metachronous bile duct cancer in Lynch syndrome: report of a case.Surg Today,2013 Jul 31. [Epub ahead of print], 2013
  33. Miwa S, Yano S, Tome Y, Sugimoto N, Hiroshima Y, Uehara F, Mii S, Kimura H, Hayashi K, Efimova EV, Fujiwara T, Tsuchiya H, Hoffman RM:Dynamic color-coded fluorescence imaging of the cell-cycle phase, mitosis, and apoptosis demonstrates how caffeine modulates cisplatinum efficacy.J Cell Biochem,114(11):2454-2460, 2013
  34. Oishi K, Miyamoto Y, Saito H, Murase K, Ono K, Sawada M, Watanabe M, Noguchi Y, Fujiwara T, Hayashi S, Noguchi H:In vivo imaging of transplanted islets labeled with a novel cationic nanoparticle. PLoS One,8(2):e57046, 2013
  35. Nobuoka D, Yoshikawa T, Sawada Y, Fujiwara T, Nakatsura T:Peptide vaccines for hepatocellular carcinoma. Hum Vaccin Immunother,9(2):210-222, 2013
  36. Lin WH, Yeh SH, Yang WJ, Yeh KH, Fujiwara T, Nii A, Chang SS, Chen PJ:Telomerase-specific oncolytic adenoviral therapy for orthotopic hepatocellular carcinoma in HBx transgenic mice.Int J Cancer,132(6):1451-1462, 2013
  37. Fujiwara Y, Yamada T, Naomoto Y, Yamatsuji T, Shirakawa Y, Tanabe S, Noma K, Kimura T, Aoki H, Matsukawa H, Kimura M, Nonaka Y, Sasaki H, Onoda T, Otawa Y, Takaoka M, Fukazawa T, Ohno Y, Fujiwara T:Multicentred surgical site infection surveillance using partitioning analysis.J Hosp Infect. ,85:282-288, 2013
  38. Kishimoto H, Momiyama M, Aki R, Kimura H, Suetsugu A, Bouvet M, Fujiwara T, Hoffman RM:Development of a clinically-precise mouse model of rectal cancer. PLoS One,8(11):e79453, 2013
  39. Tazawa H, Kagawa S, Fujiwara T:Oncolytic Adenovirus-Induced Autophagy:  Tumor-Suppressive Effect and Molecular Basis.Acta Med Okayama, 67(6):333-342, 2013
  40. Matsumoto K, Miyake Y, Umeda Y, Matsushita H, Matsuda H, Takaki A, Sadamori H, Nouso K,  Yagi T, Fujiwara, T, Yamamoto K:Serial changes of serum growth factor levels and liver regeneration after partial hepatectomy in healthy humans.Int. J. Mol. Sci.,14:20877-20889, 2013
  41. Itoh M, Iwamoto T, Matsuoka J, Nogami T, Motoki T, Shien T, Taira N, Niikura N, Hayashi N, Ohtani S, Higaki K, Fujiwara T, Doihara H, Symmans, W. F, Puszta, L :Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers. Breast Cancer Res Treat(in press), 2013
  42. Ohara T, Shirakawa Y, Noma K, Maeda N, Katsube R, Tanabe S, Fujiwara T:Direct observation diverticulectomy for Zenker’s diverticulum carcinoma. Esophagus,10:235–238, 2013
  43. Inada R, Yamamoto S, Oshiro T, Takawa M, Fujita S, Akasu T:A case-matched comparison of the short-term outcomes between laparoscopic and open abdominoperineal resection for rectal cancer.Surgery today, (in press), 2013
  44. Tazawa H, Kawaguchi T, Kobayashi T, Kuramitsu Y, Wada S, Satomi Y, Nishino H, Kobayashi M, Kanda Y, Tanaka H, Osaki M, Kitagawa T, Hosokawa M, Okada F:Chronic inflammation-derived nitric oxide converts human colonic adenoma cells into adenocarcinoma cells.Exp Cell Res,319(18):2835-2844, 2013
  45. Masuda H, Brewer TM, Liu DD, Iwamoto T, Shen Y, Hsu L, Willey JS, Gonzalez-Angulo AM, Chavez-Macgregor M, Fouad TM, Woodward WA, Reuben JM, Valero V, Alvarez RH, Hortobagyi GN, Ueno NT.:   Long-term treatment efficacy in primary inflammatory breast cancer by hormonal receptor- and HER2-defined subtypes.Ann Oncol,25(2):384-391, 2013
  46. Itoh M, Iwamoto T, Matsuoka J, Nogami T, Motoki T, Shien T, Taira N, Niikura N, Hayashi N, Ohtani S, Higaki K, Fujiwara T, Doihara H, Symmans WF, Pusztai L:Estrogen receptor (ER) mRNA expression and molecular subtype distribution in ER-negative/progesterone receptor-positive breast cancers.Breast Cancer Res Treat,143(2):403-409, 2013
  47. Bertucci F, Ueno NT, Finetti P, Vermeulen P, Lucci A, Robertson FM, Marsan M, Iwamoto T, Krishnamurthy S, Masuda H, Van Dam P, Woodward WA, Cristofanilli M, Reuben JM, Dirix L, Viens P, Symmans WF, Birnbaum D, Van Laere SJ. :Gene expression profiles of inflammatory breast cancer: correlation with response to neoadjuvant chemotherapy and metastasis-free survival. Ann Oncol,25(2):358-365, 2013
  48. Masuda H, Baggerly KA, Wang Y, Iwamoto T, Brewer T, Pusztai L, Kai K, Kogawa T, Finetti P, Birnbaum D, Dirix L, Woodward WA, Reuben JM, Krishnamurthy S, Symmans WF, Van Laere SJ, Bertucci F, Hortobagyi GN, Ueno NT:Comparison of molecular subtype distribution in triple-negative inflammatory and non-inflammatory breast cancers. Breast Cancer Res,15(6):R112, 2013
  49. Delpech Y, Coutant C, Hsu L, Barranger E, Iwamoto T, Barcenas CH, Hortobagyi GN, Rouzier R, Esteva FJ, Pusztai L:Clinical benefit from neoadjuvant chemotherapy in oestrogen receptor-positive invasive ductal and lobular carcinomas. Br J Cancer,108(2):285-291, 2013
  50. Kai K, Iwamoto T, Kobayashi T, Arima Y, Takamoto Y, Ohnishi N, Bartholomeusz C, Horii R, Akiyama F, Hortobagyi GN, Pusztai L, Saya H, Ueno NT:Ink4a/Arf(-/-) and HRAS(G12V) transform mouse mammary cells into triple-negative breast cancer containing tumorigenic CD49f(-) quiescent cells.Oncogene,23(33):440-448, 2013
  51. Van Laere SJ, Ueno NT, Finetti P, Vermeulen PB, Lucci A, Robertson FM, Marsan M, Iwamoto T, Krishnamurthy S, Masuda H, Van Dam PA, Woodward WA, Viens P, Cristofanilli M, Birnbaum D, Dirix LY, Reuben JM, Bertucci F:Uncovering the molecular secrets of Inflammatory Breast Cancer biology: An integrated analysis of three distinct Affymetrix gene expression data sets.Clin Cancer Res,1(19):4685-4696, 2013
  52. Szekely B, Iwamoto T, Szasz AM, Qi Y, Matsuoka J, Symmans WF, Tokes AM, Kulka J, Swanton C, Pusztai L:A 3-gene proliferation score (TOP-FOX-67) can re-classify histological grade-2, ER-positive breast cancers into low- and high-risk prognostic categories.Breast Cancer Res Treat,138(3):691-698, 2013
  53. Brewer TM, Masuda H, Liu DD, Shen Y, Liu P, Iwamoto T, Kai K, Barnett CM, Woodward WA, Reuben JM, Yang P, Hortobagyi GN, Ueno NT:Statin use in primary inflammatory breast cancer: a cohort study.Br J Cancer,109(2):318-324, 2013
  54. Trentini F, Ji Y, Iwamoto T, Qi Y, Pusztai L, Muller P.:Bayesian Mixture Models for Assessment of Gene Differential Behaviour and Prediction of pCR through the Integration of Copy Number and Gene Expression Data. PLoS One,8(7):e68071, 2013
  55. Wang X, Saso H, Iwamoto T, Xia W, Gong Y, Pusztai L, Woodward WA, Reuben JM, Warner SL, Bearss DJ, Hortobagyi GN, Hung MC, Ueno NT:TIG1 Promotes the Development and Progression of Inflammatory Breast Cancer through Activation of Axl Kinase.Cancer Res,73(21):6516-6525, 2013
  56. Santarpia L, Iwamoto T, Di Leo A, Hayashi N, Bottai G, Stampfer M, Andre F, Turner NC, Symmans WF, Hortobagyi GN, Pusztai L, Bianchini G:DNA repair gene patterns as prognostic and predictive factors in molecular breast cancer subtypes.Oncologist,18(10):1063-1073, 2013
  57. Bianchini G, Pusztai L, Karn T, Iwamoto T, Rody A, Kelly CM, Muller V, Schmidt M, Qi Y, Holtrich U, Becker S, Santarpia L, Fasolo A, Del Conte G, Zambetti M, Sotiriou C, Haibe-Kains B, Symmans WF, Gianni L:Proliferation and estrogen signaling can distinguish patients at risk for early versus late relapse among estrogen receptor positive breast cancers.Breast Cancer Res,15(5):R86, 2013
  58. Niikura N, Kimura M, Iwamoto T, Hayashi N, Shintoku J, Saito Y, Suzuki Y, Tokuda Y:Women prefer adjuvant endocrine therapy to chemotherapy for breast cancer treatment.Breast Cancer,20 (1):67-74, 2013
  59. Kuise T, Noguchi H, Saitoh I, Kataoka H, Watanabe M, Noguchi Y, Fujiwara T:Isolation Efficiency of Mouse Pancreatic Stem Cells Is Age Dependent. Cell Medicine,5:69-73, 2013
  60. Nishida N, Kudo M, Nishimura T, Arizumi T, Takita M, Kitai S, Yada N, Hagiwara S, Inoue T, Minami Y, Ueshima K, Sakurai T, Yokomichi N, Nagasaka T, Goel A.:Unique association between global DNA hypomethylation and chromosomal alterations in human hepatocellular carcinoma.PLoS One,8(9)e7231, 2013
  61. Toiyama Y, Takahashi M, Hur K, Nagasaka T, Tanaka K, Inoue Y, Kusunoki M,Boland CR, Goel A.: Serum miR-21 as a diagnostic and prognostic biomarker in colorectal cancer. J Natl Cancer Inst, 105(12):849-859, 2013
  62. Hur K, Toiyama Y, Takahashi M, Balaguer F, Nagasaka T, Koike J, Hemmi H, Koi M, Boland CR, Goel A.: MicroRNA-200c modulates epithelial-to-mesenchymal transition (EMT) in human colorectal cancer metastasis.Gut, 62(9):1315-1326, 2013

2012年

  1. Fujiwara T: In vivo imaging of human cancer with telomerase-specific replication-selective adenovirus. In “In Vivo Vellular Imaging Using Fluorescent Proteins” (Hoffman, R. B., ed.), pp129-139, Humana Press, c/o Springer Science + Business Media, LLC, New York, USA, 2012(著書)
  2. Umeda Y, Yagi T, Sadamori H, Fujiwara T: Small-for-size syndrome after Living donor Liver transplantation. Liver Transplantation, 2012(著書)
  3. Utsumi M, Matsuda H, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Satoh D, Hashimoto M, Yagi T, Fujiwara T: Resection of metachronous lymph node metastases from hepatocellular carcinoma after hepatectomy: report of four cases. Acta Med Okayama, 66(2): 177-182, 2012
  4. Kuroda S, Urata Y, Fujiwara T: Ataxia-telangiectasia mutated and the Mre11-Rad50-NBS1 complex: promising targets for radiosensitization. Acta Med Okayama, 66(2): 83-92, 2012
  5. Bao XH, Takaoka M, Hao HF, Wang ZG, Fukazawa T, Yamatsuji T, Sakurama K, Sun DS, Nagasaka T, Fujiwara T, Naomoto Y: Esophageal cancer exhibits resistance to a novel IGF-1R inhibitor NVP-AEW541 with maintained RAS-MAPK activity. Anticancer Res, 32(7): 2827-2834, 2012
  6. Hao HF, Takaoka M, Bao XH, Wang ZG, Tomono Y, Sakurama K, Ohara T, Fukazawa T, Yamatsuji T, Fujiwara T, Naomoto Y: Oral administration of FAK inhibitor TAE226 inhibits the progression of peritoneal dissemination of colorectal cancer. Biochem Biophys Res Commun, 423(4): 744-749, 2012
  7. Hitsuda T, Michiue H, Kitamatsu M, Fujimura A, Wang F, Yamamoto T, Han XJ, Tazawa H, Uneda A, Ohmori I, Nishiki T, Tomizawa K, Matsui H: A protein transduction method using oligo-arginine (3R) for the delivery of transcrition factors into cell nuclei. Biomaterials, 33(18): 4665-4672, 2012
  8. Yukawa H, Watanabe M, Kaji N, Okamoto Y, Tokeshi M, Miyamoto Y, Noguchi H, Baba Y, Hayashi S: Monitoring transplanted adipose tissue-derived stem cells combined with heparin in the liver by fluorescence imaging using quantum dots. Biomaterials, 33(7): 2177-2186, 2012
  9. Takakura M, Kyo S, Nakamura M, Maida Y, Mizumoto Y, Bono Y, Zhang X, Hashimoto Y, Urata Y, Fujiwara T, Inoue M: Circulating tumour cells detected by a novel adenovirus-mediated system may be a potent therapeutic marker in gynaecological cancers. Br J Cancer, 107(3):448-454, 2012
  10. Watanabe Y, Hashimoto Y, Kagawa S, Kawamura H, Nagai K, Tanaka N, Urata Y, Fujiwara T: Enhanced antitumor efficacy of telomerase-specific oncolytic adenovirus with valproic acid against human cancer cells. Cancer Gene Ther, 19(11): 767-772, 2012
  11. Yoshida R, Tazawa H, Hashimoto Y, Yano S, Onishi T, Sasaki T, Shirakawa Y, Kishimoto H, Uno F, Nishizaki M, Kagawa S, Fujiwara T: Mechanism of resistance to trastuzumab and molecular sensitization via ADCC activation by exogenous expression of HER2-extracellular domain in human cancer cells. Cancer Immunol Immunother, 61(11): 1905-1916, 2012
  12. Niikura N, Iwamoto T, Masuda S, Kumaki N, Xiaoyan T, Shirane M, Mori K, Tsuda B, Okamura T, Saito Y, Suzuki Y, Tokuda Y: Immunohistochemical Ki67 labeling index has similar proliferation predictive power to various gene signatures in breast cancer. Cancer Sci, 103: 1508-1512, 2012
  13. Noguchi H, Naziruddin B, Shimoda M, Chujo D, Takita M, Sugimoto K, Itoh T, Onaca N, Levy MF, Matsumoto S: A combined continuous density/osmolality gradient for supplemental purification of human islets. Cell Med, 3(1-3): 33-41, 2012
  14. Oishi K, Noguchi H, Saito H, Yukawa H, Miyamoto Y, Ono K, Murase K, Sawada M, Hayashi S: Novel positive-charged nanoparticles for efficient magnetic resonance imaging of islet transplantation. Cell Med, 3 (1-3): 43-49, 2012
  15. Yukawa H, Noguchi H, Oishi K, Miyamoto Y, Inoue M, Hasegawa M, Hayashi S, Baba Y: Differentiation of Mouse Pancreatic Stem Cells Into Insulin-Producing Cells by Recombinant Sendai Virus-Mediated Gene Transfer Technology. Cell Med, 3(1-3): 51-61, 2012
  16. Miyamoto Y, Noguchi H, Yukawa H, Oishi K, Matsushita K, Iwata H, Hayashi S: Cryopreservation of Induced Pluripotent Stem Cells. Cell Med, 3 (1-3): 89-95, 2012
  17. Saitoh I, Sato M, Iwase Y, Inada E, Nomura T, Akasaka E, Yamasaki Y, Noguchi H: Generation of mouse STO feeder cell lines that confer resistance to several types of selective drugs. Cell Med, 3(1-3): 97-102, 2012
  18. Takita M, Matsumoto S, Qin H, Noguchi H, Shimoda M, Chujo D, Itoh T, Sugimoto K, Onaca N, Naziruddin B, Levy MF: Secretory Unit of Islet Transplant Objects (SUITO) Index Can Predict Severity of Hypoglycemic Episodes in Clinical Islet Cell Transplantation. Cell Transplant, 21(1): 91-98, 2012
  19. Shimoda M, Noguchi H, Fujita Y, Takita M, Ikemoto T, Chujo D, Naziruddin B, Levy MF, Kobayashi N, Grayburn PA, Matsumoto S: Improvement of porcine islet isolation by inhibition of trypsin activity during pancreas preservation and digestion using α1-antitrypsin. Cell Transplant, 21(2-3):465-471, 2012
  20. Noguchi H, Naziruddin B, Shimoda M, Fujita Y, Chujo D, Takita M, Peng H, Sugimoto K, Itoh T, Kobayashi N, Onaca N, Levy MF, Matsumoto S: Evaluation of osmolality of density gradient for human islet purification. Cell Transplant, 21(2-3): 493-500, 2012
  21. Shimoda M, Noguchi H, Fujita Y, Takita M, Ikemoto T, Chujo D, Naziruddin B, Levy MF, Kobayashi N, Grayburn PA, Matsumoto S: Islet purification method using large bottles effectively achieves high islet yield from pig pancreas. Cell Transplant, 21(2-3): 501-508, 2012
  22. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Fujita Y, Chujo D, Takita M, Peng H, Sugimoto K, Itoh T, Kobayashi N, Ueda M, Okitsu T, Iwanaga Y, Nagata H, Liu X, Kamiya H, Onaca N, Levy MF, Matsumoto S: Comparison of ulinastatin, gabexate mesilate, and nafamostat mesilate in preservation solution for islet isolation. Cell Transplant, 21(2-3): 509-516, 2012
  23. Noguchi H, Naziruddin B, Jackson A, Shimoda M, Ikemoto T, Fujita Y, Chujo D, Takita M, Peng H, Sugimoto K, Itoh T, Kobayashi N, Onaca N, Levy MF, Matsumoto S: Fresh islets are more effective for islet transplantation than cultured islets. Cell Transplant, 21(2-3): 517-523, 2012
  24. Takita M, Matsumoto S, Noguchi H, Shimoda M, Ikemoto T, Chujo D, Tamura Y, Olsen GS, Naziruddin B, Purcell K, Onaca N, Levy MF: Adverse events in clinical islet transplantation: one institutional experience. Cell Transplant, 21(2-3): 547-551, 2012
  25. Naziruddin B, Matsumoto S, Noguchi H, Takita M, Shimoda M, Fujita Y, Chujo D, Tate C, Onaca N, Lamont J, Kobayashi N, Levy MF: Improved pancreatic islet isolation outcome in autologous transplantation for chronic pancreatitis. Cell Transplant, 21(2-3): 553-558, 2012
  26. Hayashi T, Misawa H, Nakahara H, Noguchi H, Yoshida A, Kobayashi N, Tanaka M, Ozaki T: Transplantation of osteogenically differentiated mouse iPS cells for bone repair. Cell Transplant, 21(2-3): 591-600, 2012
  27. Miyamoto Y, Oishi K, Yukawa H, Noguchi H, Sasaki M, Iwata H, Hayashi S: Cryopreservation of human adipose tissue-derived stem/progenitor cells using the silk protein sericin. Cell Transplant, 21(2-3): 617-622, 2012
  28. Kanamune J, Iwanaga Y, Kina T, Noguchi H, Matsumura K, Uemoto S, Hyon SH: Attenuation of murine graft-versus-host disease by a tea polyphenol. Cell Transplant, 21(5): 909-918, 2012
  29. Gonzalez-Angulo AM, Iwamoto T, Liu S, Chen H, Do KA, Hortobagyi GN, Mills GB, Meric-Bernstam F, Symmans WF, Pusztai L: Gene expression, molecular class changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer. Clin Cancer Res, 18: 1109-1119, 2012
  30. Sawada Y, Yoshikawa T, Nobuoka D, Shirakawa H, Kuronuma T, Motomura Y, Mizuno S, Ishii H, Nakachi K, Konishi M, Nakagohri T, Takahashi S, Gotohda N, Takayama T, Yamao K, Uesaka K, Furuse J, Kinoshita T, Nakatsura T: Phase I trial of glypican-3-derived peptide vaccine for advanced hepatocellular carcinoma showed immunological evidence and potential for improving overall survival. Clin Cancer Res, 18(13): 3686-3696, 2012
  31. Yagi T, Shinoura S, Umeda Y, Sato D, Yoshida R, Yoshida K, Utsumi M, Nobuoka D, Sadamori H, Fujiwara T: Surgical rationalization of living donor liver transplantation by abolition of hepatic artery reconstruction under a fixed microscope. Clin Transplant, 26(6): 877-883, 2012
  32. Fujiwara T, Kagawa S,Tazawa H: Synergistic interaction of telomerase-specific oncolytic virotherapy and chemotherapeutic agents for human cancer. Curr Pharm Biotechnol, 13(9): 1809-1816, 2012
  33. Sadamori H, Yagi T, Matsuda H, Shinoura S, Umeda Y, Fujiwara T: Intractable bile leakage after hepatectomy for hepatocellular carcinoma in 359 recent cases. Dig Surg, 29(2): 149-156, 2012
  34. Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S, Yoshida R, Uno F, Mizuguchi H, Ohtsuru A, Urata Y, Kagawa S,Fujiwara T: A novel apoptotic mechanism of genetically engineered adenovirus-mediated tumour-specific p53 overexpression through E1A-dependent p21 and MDM2 suppression. Eur J Cancer, 48(14): 2282-2291, 2012
  35. Obika M, Noguchi H: Diagnosis and evaluation of nonalcoholic Fatty liver disease. Exp Diabetes Res, 145754 (online only journal), 2012
  36. Matsuda H, Sadamori H, Umeda Y, Shinoura S, Yoshida R, Satoh D, Utsumi M, Yagi T, Fujiwara T: Preventive effect of omental flap in pancreaticoduodenectomy against postoperative pseudoaneurysm formation. Hepatogastroenterology, 59(114): 578-583, 2012
  37. Toyooka S, Kiura K, Takemoto M, Oto T, Takigawa N, Fujiwara T, Miyoshi S, Date H: Long-term outcome of induction chemoradiotherapy with docetaxel and cisplatin followed by surgery for non-small-cell lung cancer with mediastinal lymph node metastasis. Interact Cardiovasc Thorac Surg, 14(5): 565-569, 2012
  38. Tazawa H, Yano S, Yoshida R, Yamasaki Y, Sasaki T, Hashimoto Y, Kuroda S, Ouchi M, Onishi T, Uno F, Kagawa S, Urata Y, Fujiwara T: Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis. Int J Cancer, 131(12): 2939-2950, 2012
  39. Tanaka S, Shiraha H, Nakanishi Y, Nishina S, Matsubara M, Horiguchi S, Takaoka N, Iwamuro M, Kataoka J, Kuwaki K, Hagihara H, Toshimori J, Ohnishi H, Takaki A, Nakamura S, Nouso K, Yagi T, Yamamoto K: Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma. Int J Cancer, 131(11): 2537-2546, 2012
  40. Matsumi J, Morimatsu H, Matsusaki T, Kaku R, Shimizu H, Takahashi T, Yagi T, Matsumi M, Morita K: Heme breakdown and ischemia/reperfusion injury in grafted liver during living donor liver transplantation. Int J Mol Med, 29:135-140, 2012
  41. Nobuoka D, Motomura Y, Shirakawa H, Yoshikawa T, Kuronuma T, Takahashi M, Nakachi K, Ishii H, Furuse J, Gotohda N, Takahashi S, Nakagohri T, Konishi M, Kinoshita T, Komori H, Baba H, Fujiwara T, Nakatsura T: Radiofrequency ablation for hepatocellular carcinoma induces glypican-3 peptide-specific cytotoxic T lymphocytes. Int J Oncol, 40(1): 63-70, 2012
  42. Ueki H, Watanabe M, Kaku H, Huang P, Li SA, Ochiai K, Hirata T, Noguchi H, Yamada H, Takei K, Nasu Y, Kashiwakura Y, Kumon H: A novel gene expression system for detecting viable bladder cancer cells. Int J Oncol, 41(1): 135-140, 2012
  43. Iwamoto T, Booser D, Valero V, Murray JL, Koenig K, Esteva FJ, Ueno NT, Zhang J, Shi W, Qi Y, Matsuoka J, Yang EJ, Hortobagyi GN, Hatzis C, Symmans WF, Pusztai L: Estrogen Receptor (ER) mRNA and ER-Related Gene Expression in Breast Cancers That Are 1% to 10% ER-Positive by Immunohistochemistry. J Clin Oncol, 30: 729-734, 2012
  44. Sadamori H, Fujiwara H, Tanaka T, Yanai H, Satoh D, Yagi T,Fujiwara T: Carcinosarcoma of the gallbladder manifesting as cholangitis due to hemobilia. J Gastrointest Surg, 16(6): 1278-1281, 2012
  45. Yoshida R, Yagi T, Sadamori H, Matsuda H, Shinoura S, Umeda Y, Sato D, Utsumi M, Nagasaka T, Okazaki N, Date A, Noguchi A, Tanaka A, Hasegawa Y, Sakamoto Y, Fujiwara T: Branched-chain amino acid-enriched nutrients improve nutritional and metabolic abnormalities in the early post-transplant period after living donor liver transplantation. J Hepatobiliary Pancreat Sci, 19(4): 438-448, 2012
  46. Yamada E, Shirakawa Y, Yamatsuji T, Sakuma L, Takaoka M, Yamada T, Noma K, Sakurama K, Fujiwara Y, Tanabe S, Nagasaka T, Fujiwara T, Naomoto Y: Jejunal interposition reconstruction with a stomach preserving esophagectomy improves postoperative weight loss and reflux symptoms for esophageal cancer patients. J Surg Res, 178(2):700-707, 2012
  47. Kelly CM, Bernard PS, Krishnamurthy S, Wang B, Ebbert MT, Bastien RR, Boucher KM, Young E, Iwamoto T, Pusztai L: Agreement in risk prediction between the 21-gene recurrence score assay (Oncotype DX(R)) and the PAM50 breast cancer intrinsic Classifier in early-stage estrogen receptor-positive breast cancer. Oncologist, 17:492-498, 2012
  48. Yamauchi H, Woodward WA, Valero V, Alvarez RH, Lucci A, Buchholz TA, Iwamoto T, Krishnamurthy S, Yang W, Reuben JM, Hortobagyi GN, Ueno NT : Inflammatory breast cancer: what we know and what we need to learn. Oncologist, 17: 891-899, 2012
  49. Sugimoto M, Watanabe M, Kaku H, Li SA, Noguchi H, Ueki H, Sakaguchi M, Huh NH, Nasu Y, Kumon H: Preclinical biodistribution and safety study of reduced expression in immortalized cells/Dickkopf-3-encoding adenoviral vector for prostate cancer gene therapy. Oncol Rep, 28(5):1645-1652, 2012
  50. Hashimoto Y, Tazawa H, Teraishi F, Kojima T, Watanabe Y, Uno F, Yano S, Urata Y, Kagawa S, Fujiwara T: The hTERT promoter enhances the antitumor activity of an oncolytic adenovirus under a hypoxic microenvironment. PLoS One, 7(6)1-10, 2012
  51. Zhang W, Kai K, Choi DS, Iwamoto T, Nguyen YH, Wong H, Landis MD, Ueno NT, Chang J, Qin L: Microfluidics separation reveals the stem-cell-like deformability of tumor-initiating cells. Proc Natl Acad Sci U S A, 109:18707-18712, 2012
  52. Takehara K, Aoki H, Takehara Y, Yamasaki R, Tanakaya K, Takeuchi H: Primary hepatic leiomyosarcoma with liver metastasis of rectal cancer. World J Gastroenterol, 18(38): 5479-5484, 2012

2011年

  1. Kishimoto H, Aki R, Urata Y, Bouvet M, Moriyama M, Tanaka N, Fujiwara T, Hoffman R. M: Tumor-selective adenoviral-mediated GFP genetic labeling of human cancer in the live mouse reports future recurrence after resection. Cell Cycle,210: 2737-2741,2011
  2. Tazawa H, Kagawa S, Fujiwara T: MicroRNAs as potential target gene in cancer gene therapy of gastrointestinal tumors. Expert Opin Biol Ther,11(2): 145-155,2011
  3. Shirakawa Y, Tanabe S, Noma K, Sakurama K, Fujiwara T: Surgery for cancers at the esophagogastric junction and Barrett's esophageal cancers.Nihon Rinsho. (Japanese),69 (Suppl 6): 322-328,2011
  4. Fujiwara T: A novel molecular therapy using bioengineered adenovirus for human gastrointestinal cancer. Acta Med Okayama,65(3): 151-162,2011
  5. Takeda M, Nagasaka T, Dong-Sheng S, Nishie H, Oka T, Yamada E, Mori Y, Shigeyasu K, Morikawa T, Mizobuchi S, Fujiwara T: Expansion of CpG methylation in the SFRP2 promoter region during colorectal tumorigenesis. Acta Med Okayama,65(3): 169-177,2011
  6. Sasaki T, Tazawa H, Hasei J, Kunisada T, Yoshida A, Hashimoto Y, Yano S,Yoshida R, Uno F, Kagawa S, Morimoto Y, Urata Y, Ozaki T, Fujiwara T: Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas. Clin Cancer Res,17(7): 1828-1838,2011
  7. Sugio K, Sakurai F, Katayama K, Tashiro K, Matsui H, Kawabata K, Kawase A, Iwaki M, Hayakawa T, Fujiwara T, Mizuguchi H: Enhanced safety profiles of the telomerase-specific replication-competent adenovirus by incorporation of normal cell-specific microRNA-targeted sequences. Clin Cancer Res,17(9): 2807-2818,2011
  8. Fujiwara T, Shirakawa Y, Kagawa S: Telomerase-specific oncolytic virotherapy for human gastrointestinal cancer.Expert Rev Anticancer Ther,11(4): 525-532,2011
  9. Motoki T, Naomoto Y, Hoshiba J, Shirakawa Y, Yamatsuji T, Matsuoka J, Takaoka M, Tomono Y, Fujiwara Y, Tsuchita H, Gunduz M, Nagatsuka H, Tanaka N, Fujiwara T: Glutamine depletion induces murine neonatal melena with increased apoptosis of the intestinal epithelium. World J Gastroenterol,17(6): 717-726,2011
  10. Tanabe S, Naomoto Y, Shirakawa Y, Fujiwara Y, Sakurama K, Noma K, Takaoka M, Yamatsuji T, Hiraki T, Okumura Y, Mitani M, Kaji M, Kanazawa S, Fujiwara T: F-18 FDG PET/CT contributes to more accurate detection of lymph nodal metastasis from actively proliferating esophageal squamous cell carcinoma.Clin Nucl Med,36(10): 854-859,2011
  11. Ohara T, Takaoka M, Toyooka S, Tomono Y, Nishikawa T, Shirakawa Y, Yamatsuji T, Tanaka N, Fujiwara T, Naomoto Y: Inhibition of mTOR by temsirolimus contributes to prolonged survival of mice with pleural dissemination of non-small-cell lung cancer cells.Cancer Sci,102(7): 1344-1349,2011
  12. Umeda Y, Matsuda H, Sadamori H, Shinoura S, Yoshida R, Sato D, Utsumi M, Yagi T, Fujiwara T: Leukoencephalopathy syndrome after living-donor liver transplantation. Exp Clin Transplant,9(2): 139-144,2011
  13. Iwamoto T, Bianchini G, Qi Y, Cristofanilli M, Lucci A, Woodward WA, Reuben JM, Matsuoka J, Gong Y, Krishnamurthy S, Valero V, Hortobagyi GN, Robertson F, Symmans WF, Pusztai L, Ueno NT: Different gene expressions are associated with the different molecular subtypes of inflammatory breast cancer. Breast Cancer Res Treat, 125: 785-795,2011
  14. Iwamoto T, Bianchini G, Booser D, Qi Y, Coutant C, Shiang CY, Santarpia L, Matsuoka J, Hortobagyi GN, Symmans WF, Holmes FA, O'Shaughnessy J, Hellerstedt B, Pippen J, Andre F, Simon R, Pusztai L: Gene Pathways Associated With Prognosis and Chemotherapy Sensitivity in Molecular Subtypes of Breast Cancer.J Natl Cancer Inst,103(3): 264-272,2011
  15. Coutant C, Rouzier R, Qi YA, Lehmann-Che J, Bianchini G, Iwamoto T, Hortobagyi GN, Symmans WF, Uzan S, Andre F, de The H, Pusztai L: Distinct p53 Gene Signatures Are Needed to Predict Prognosis and Response to Chemotherapy in ER-Positive and ER-Negative Breast Cancers. Clinical Cancer Research, 17: 2591-2601,2011
  16. Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, Jellema G, Deharo S, Hardie DG, Pusztai L, Moulder-Thompson S, Dewar JA, Thompson AM: Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial.Breast Cancer Res Treat,128: 783-794,2011
  17. Iwamoto T, Lee JS, Bianchini G, Hubbard RE, Young E, Matsuoka J, Kim SB, Symmans WF, Hortobagyi GN, Pusztai L: First generation prognostic gene signatures for breast cancer predict both survival and chemotherapy sensitivity and identify overlapping patient populations. Breast Cancer Res Treat,130: 155-164,2011
  18. Hayashi N, Iwamoto T, Gonzalez-Angulo AM, Ferrer-Lozano J, Lluch A, Niikura N, Bartholomeusz C, Nakamura S, Hortobagyi GN, Ueno NT: Prognostic impact of phosphorylated HER-2 in HER-2+ primary breast cancer. Oncologist, 16:956-965,16: 956-965,2011
  19. Niikura N, Kimura M, Iwamoto T, Hayashi N, Shintoku J, Saito Y, Suzuki Y, Tokuda Y: Women prefer adjuvant endocrine therapy to chemotherapy for breast cancer treatment. Breast Cancer, 2011
  20. Hess KR, Wei C, Qi Y, Iwamoto T, Symmans WF, Pusztai L: Lack of sufficiently strong informative features limits the potential of gene expression analysis as predictive tool for many clinical classification problems.BMC Bioinformatics,12: 463,2011
  21. Karn T, Pusztai L, Holtrich U, Iwamoto T, Shiang CY, Schmidt M, Muller V, Solbach C, Gaetje R, Hanker L, Ahr A, Liedtke C, Ruckhaberle E, Kaufmann M, Rody A: Homogeneous datasets of triple negative breast cancers enable the identification of novel prognostic and predictive signatures.PLoS One, 6: e28403,2011
  22. Harada S, Sato S, Suzuki E, Okumura Y, Hiraki T, Gobara H, Mimura H, Kanazawa S, Kaji M, Fujiwara T: The usefulness of pre-radiofrequency ablation SUV(max) in 18F-FDG PET/CT to predict the risk of a local recurrence of malignant lung tumors after lung radiofrequency ablation. Acta Med Okayama,65(6): 395-402,2011
  23. Umeda Y, Matsuda H, Sadamori H, Matsukawa H, Yagi T, Fujiwara T: A Prognostic Model and Treatment Strategy for Intrahepatic Recurrence of Hepatocellular Carcinoma after Curative Resection.World J Surg,35(1): 170-177,2011
  24. Gonzalez-Angulo AM, Iwamoto T, Liu S, Chen H, Do KA, Hortobagyi GN, Mills GB, Meric-Bernstam F, Symmans WF, Pusztai L: Gene expression, molecular class changes, and pathway analysis after neoadjuvant systemic therapy for breast cancer.Clin Cancer Res,18: 1109-1119,2011
  25. Hadad S, Iwamoto T, Jordan L, Purdie C, Bray S, Baker L, Jellema G, Deharo S, Hardie DG, Pusztai L. Moulder-Thompson S, Dewar JA, Thompson AM: Evidence for biological effects of metformin in operable breast cancer: a pre-operative, window-of-opportunity, randomized trial. Breast Cancer Res Treat,128: 783-794,2011
  26. Fujita Y, Takita M, Shimoda M, Itoh T, Sugimoto K, Noguchi H, Naziruddin B, Levy MF, Matsumoto S: Large human islets secrete less insulin per islet equivalent than smaller islets in vitro.Islets,3(1): 1-5,2011
  27. Yukawa H, Noguchi H, Hayashi S: Embryonic body formation using the tapered soft stencil for cluster culture device.Biomaterials, 32(15): 3729-3738,2011
  28. Takita M, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Itoh T, Sugimoto K, Sorelle JA, Onaca N, Naziruddin B, Levy MF: Cluster analysis of self-monitoring blood glucose assessments in clinical islet cell transplantation for type 1 diabetes.Diabetes Care,34(8): 1799-1803,2011
  29. Ochiai K, Watanabe M, Ueki H, Huang P, Fujii Y, Nasu Y, Noguchi H, Hirata T, Sakaguchi M, Huh NH, Kashiwakura Y, Kaku H, Kumon H: Tumor suppressor REIC/Dkk-3 interacts with the dynein light chain, Tctex-1.Biochem Biophys Res Commun,412(2): 391-395,2011
  30. Akasaki Y, Watanabe M, Yukawa H, Sabarudin A, Inagaki K, Kaji N, Okamoto Y, Tokeshi M, Miyamoto Y, Noguchi H, Umemura T, Hayashi S, Baba Y, Haraguchi H: Estimation of the distribution of intravenously injected adipose tissue-derived stem cells labeled with quantum dots in mice organs through the determination of their metallic components by ICPMS.Anal Chem,83(21): 8252-8258,2011
  31. Li G, Kawashima H, Ogose A, Ariizumi T, Xu Y, Hotta T, Urata Y, Fujiwara T, Endo N: Eicient virotherapy for osteosarcoma by telomerase-specific oncolytic adenovirus.J Cancer Res Clin Oncol,137: 1037-1051,2011
  32. Yasunaka T, Takaki A, Yagi T, Iwasaki Y, Sadamori H, Koike K, Hirohata S, Tatsukawa M, Kawai D, Shiraha H, Miyake Y, Ikeda F, Kobashi H, Matsuda H, Shinoura S, Yoshida R, Satoh D, Utsumi M, Onishi T, Yamamoto K(Department of Gastroenterology and Hepatology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama, Japan): Serum hepatitis B virus DNA before liver transplantation correlates with HBV reinfection rate even under successful low-dose hepatitis B immunoglobulin prophylaxis. Hepatol Int. [Epub ahead of print], 2011
  33. Takita M, Naziruddin B, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Itoh T, Sugimoto K, Tamura Y, Olsen GS, Onaca N, Lamont J, Lara LF, Levy MF: Body mass index reflects islet isolation outcome in islet autotransplantation for patients with chronic pancreatitis. Cell Transplant,20(2): 313-322,2011
  34. Fujiwara T, Kagawa S, Tazawa H: Synergistic Interaction of Telomerase-Specific Oncolytic Virotherapy and Chemotherapeutic Agents for Human Cancer. Curr Pharm Biotechnol, 2011
  35. Takita M, Naziruddin B, Matsumoto S, Noguchi H, Shimoda M, Chujo D, Itoh T, Sugimoto K, Onaca N, Lamont J, Lara LF, Levy MF: Implication of pancreatic image findings in total pancreatectomy with islet autotransplantation for chronic pancreatitis. Pancreas,40(1): 103-108,2011
  36. Ikemoto T, Sugimoto K, Takita M, Shimoda M, Noguchi H, Naziruddin B, Levy MF, Shimada M, Matsumoto S: Japanese Herbal Medicine TJ-48 Prevents Autoimmune Diabetes in NOD Mice. Am J Chin Med,39(4): 743-756,2011
  37. Matsumoto S, Takita M, Chaussabel D, Noguchi H, Shimoda M, Sugimoto K, Itoh T, Chujo D, Sorelle J, Onaca N, Naziruddin B, Levy MF: Improving Efficacy of Clinical Islet Transplantation with Iodixanol Based Islet Purification, Thymoglobulin Induction and Blockage of IL-1-beta and TNF-alpha. Cell Transplant,20(10): 1641-1647,2011
  38. Minami K. Doi R, Kawaguchi Y, Nukaya D, Hagiwara Y, Noguchi H, Matsumoto S, Seino S: In vitro generation of insulin-secreting cells from human pancreatic exocrine cells. Journal of Diabetes Investigation,2: 271-275,2011
  39. Kuise T, Noguchi H:Recent progress in pancreatic islet transplantation. World J Transplant,1(1): 13-18,2011
  40. Noguchi H:Pancreas procurement and preservation for islet transplantation: personal considerations.J Transplant,783168,

2010年

  1. Nagasaka T, Rhees J, Kloor M, Gebert J, Naomoto Y, Boland CR, Goel A:Somatic hypermethylation of MSH2 is a frequent event in lynch syndrome colorectal cancers.Cancer Res, 70(8): 3098-3108,2010
  2. Ohashi K, Takahashi HK, Mori S, Liu K, Wake H, Sadamori H, Matsuda H, Yagi T, Yoshino T, Nishibori M, Tanaka N:Advanced glycation end products enhance monocyte activation durinç human mixed lymphocyte reaction.Clin Immunol, 134(3): 345-353,2010
  3. Ohara T, Takaoka M, Sakurama K, Nagaishi K, Takeda H, Shirakawa Y, Yamatsuji T, Nagasaka T, Matsuoka J, Tanaka N, Naomoto Y:The establishment of a new mouse model with orthotopic esophageal cancer showing the esophageal stricture.Cancer Lett, 293(2): 207-212,2010
  4. Nagasaka T, Goel A, Hamelin R, Boland CR., Division of Gastroenterology, Department of Internal Medicine, Baylor University Medical Center, Dallas, Texas, United States of America:An optimized pentaplex PCR for detecting DNA mismatch repair-deficient colorectal cancers.PLoS One. 5(2): e9393,2010
  5. Matsuda H, Sadamori H, Shinoura S, Umeda Y, Yoshida R, Satoh D, Utsumi M, Onishi T, Yagi T:Aggressive combined resection of hepatic inferior vena cava, with replacement by a ringed expanded polytetrafluoroethylene graft, in living-donor liver transplantation for hepatocellular carcinoma beyond the Milan criteria.J Hepatobiliary Pancreat Sci. 17(5): 719-724,2010
  6. Sadamori H, Yagi T, Matsuda H, Shinoura S, Umeda Y, Yoshida R, Satoh D, Utsumi T,Ohnishi T:Risk factors for major morbidity after hepatectomy for hepatocellular carcinoma in 293 recent cases.J Hepatobiliary Pancreat Sci. 17(5):709-718,2010
  7. Sakai R, Kagawa S, Yamasaki Y, Kojima T, Uno F, Hashimoto Y, Watanabe Y, Urata Y, Tanaka N, Fujiwara T:Preclinical evaluation of differentially targeting dual virotherapy for human solid cancer. Mol Cancer Ther. 9(6):1884-1893,2010
  8. Kuroda S, Fujiwara T, Shirakawa Y, Yamasaki Y, Yano S, Uno F, Tazawa H, Hashimoto Y, Watanabe Y, Noma K, Urata Y, Kagawa S, Fujiwara T:Telomerase-Dependent Oncolytic Adenovirus Sensitizes Human Cancer Cells to Ionizing Radiation via Inhibition of DNA Repair Machinery.Cancer Res, 70(22): 9339-9348,2010
  9. Kojima T, Watanabe Y, Hashimoto Y, Kuroda S, Yamasaki Y, Yano S, Ouchi M, Tazawa H, Uno F, Kagawa S, Kyo S, Mizuguchi H, Urata Y, Tanaka N, Fujiwara T: In vivo biological purging for lymph node metastasis of human colorectal cancer by telomerase-specific oncolytic virotherapy. Ann Surg, 251(6): 1079-1086,2010
  10. Sonoda R, Naomoto Y, Shirakawa Y, Fujiwara Y, Yamatsuji T, Noma K, Tanabe S,Takaoka M, Gunduz M, Tsujigiwa H, Nagatsuka H, Ohara N, Yoshino T, Takubo K,Vieth M, Tanaka N:Preferential up-regulation of heparanase and cyclooxygenase-2 in carcinogenesis of Barrett's oesophagus and intestinal-type gastric carcinoma.Histopathology,57(1): 90-100,2010
  11. Bao XH, Naomoto Y, Hao HF, Watanabe N, Sakurama K, Noma K, Motoki T, Tomono Y, Fukazawa T, Shirakawa Y, Yamatsuji T, Matsuoka J, Takaoka M.:Autophagy: Can it become a potential therapeutic target? Int J Mol Med. 25(4): 493-503,2010
  12. Fukazawa T, Matsuoka J, Yamatsuji T, Maeda Y, Durbin ML, Naomoto Y.:Adenovirus-mediated cancer gene therapy and virotherapy (Review). Int J Mol Med,25(1): 3-10,2010 Miyamura T, Chayama K, Yoshida R, Yagi T, Matsukawa H, Ishida T, Washio K, Morishita N, Oda M, Morishima T:Successful treatment of unresectable advanced hepatoblastoma: Living liver transplantation after surgical removal of lung metastasis.Pediatr Transplant,2010
  13. P Huang, H Kaku, J Chen, Y Kashiwakura, T Saika, Y Nasu, Y Urata, T Fujiwara, M Watanabe, H Kumon:Potent antitumor effects of combined therapy with a telomerase-specific, replication-competent adenovirus (OBP-301) and IL-2 in a mouse model of renal cell carcinoma.Cancer Gene Ther,17(7): 484-491,2010
  14. Watanabe Y, Kojima T, Kagawa S, Uno F, Hashimoto Y, Kyo S, Mizuguchi H, Tanaka N, Kawamura H, Ichimaru D, Urata Y, Fujiwara T.:A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy.Oncogene, 29(8): 1145-1154,2010
  15. Shahid JM, Iwamuro M, Sasamoto H, Kubota Y, Seita M, Kawamoto H, Nakaji S, Noguchi H, Yamamoto K, Kobayashi N:Establishment of an immortalized porcine liver cell line JSNK-1 with retroviral transduction of SV40T. Cell Transplant,19(6): 849-856,2010 Hao H, Naomoto Y, Bao X, Watanabe N, Sakurama K, Noma K, Motoki T, Tomono Y, Fukazawa T, Shirakawa Y, Yamatsuji T, Matsuoka J, Takaoka M:HSP90 and its inhibitors.Oncol Rep, 23(6): 1483-1492,2010
  16. Goel A, Nagasaka T, Spiegel J, Meyer R, Lichliter WE, Boland CR:Low frequency of Lynch syndrome among young patients with non-familial colorectal cancer.Clin Gastroenterol Hepatol,8(11): 966-971,2010
  17. Balaguer F, Link A, Lozano JJ, Cuatrecasas M, Nagasaka T, Boland CR, Goel A. (Department of Internal Medicine, Division of Gastroenterology, Charles A Sammons Cancer Center and Baylor Research Institute, Baylor University Medical Center, Dallas, Texas, USA): Epigenetic silencing of miR-137 is an early event in colorectal carcinogenesis.Cancer Res. 70(16): 6609-6618,2010
  18. Kagawa S, Uno F, Gochi A, Naomoto Y, Fujiwara T.:Portal/splenic Vein Thrombosis Following Splenectomy in Gastric Cancer Surgery.Asian Journal of Surgery, 33(4): 208-211,2010
  19. Takakura M, Nakamura M, Kyo S, Hashimoto M, Mori N, Ikoma T, Mizumoto Y, Fujiwara T, Urata Y, Inoue M: Intraperitoneal administration of telomerase-specific oncolytic adenovirus sensitizes ovarian cancer cells to cisplatin and affects survival in a xenograft model with peritoneal dissemination. Cancer Gene Ther, 17: 11-19,2010
  20. Nemunaitis J, Tong A. W, Nemunaitis M, Senzer N, Phadke A P, Bedell C, Adams N, Zhang Y A, Maple P B, Chen S, Pappen B, Burke J, Ichimaru D, Urata Y, Fujiwara T: A phase I study of telomerase specific replication competent oncolytic adenovirus (Telomelysin) for various solid tumors. Mol Ther,18: 429-434,2010
  21. Kawamoto H, Yuasa T, Kubota Y, Seita M, Sasamoto H, Shahid JM, Hayashi T, Nakahara H, Hassan R, Iwamuro M, Kondo E, Nakaji S, Tanaka N, Kobayashi N.:Characteristics of CD133(+) human colon cancer SW620 cells. Cell Transplant, 19(6):857-864,2010
  22. Navarro-Alvarez N, Kondo E, Kawamoto H, Hassan W, Yuasa T, Kubota Y, Seita M, Nakahara H, Hayashi T, Nishikawa Y, Hassan RA, Javed SM, Noguchi H, Matsumoto S, Nakaji S, Tanaka N, Kobayashi N, Soto-Gutierrez A:Isolation and propagation of a human CD133(-) colon tumor-derived cell line with tumorigenic and angiogenic properties. Cell Transplant,19(6):865-877,2010
  23. Navarro-Alvarez N, Soto-Gutierrez A, Kobayashi N:Hepatic stem cells and liver development.Methods Mol Biol, 640: 181-236,2010
  24. Fujita H, Kurokawa K, Ogino T, Ono M, Yamamoto M, Oka T, Nakanishi T, Kobayashi N, Tanaka N, Ogawa T, Suzaki E, Utsumi K, Sasaki J:Effect of Risedronate on Osteoblast Differentiation, Expression of Receptor Activator of NF-κB Ligand and Apoptosis in Mesenchymal Stem Cells. Basic Clin Pharmacol Toxicol. 2010
  25. Yamamoto T, Navarro-Alvarez N, Soto-Gutierrez A, Yuasa T, Iwamuro M, Kubota Y, Seita M, Kawamoto H, Javed SM, Kondo E, Noguchi H, Kobayashi S, Nakaji S, Kobayashi N:Treatment of acute liver failure in mice by hepatocyte xenotransplantation.Cell Transplant,19(6): 799-806,2010
  26. Soto-Gutierrez A, Navarro-Alvarez N, Yagi H, Nahmias Y, Yarmush ML, Kobayashi N:Engineering of an hepatic organoid to develop liver assist devices.Cell Transplant,19(6): 815-822,2010
  27. Nakahara H, Misawa H, Yoshida A, Hayashi T, Tanaka M, Furumatsu T, Tanaka N, Kobayashi N, Ozaki T:Bone repair using a hybrid scaffold of self-assembling peptide PuraMatrix and polyetheretherketone cage in rats.Cell Transplant,19(6):791-797,2010
  28. Kobayashi N, Amemiya H, Nagao T, Takahara S:Taking a lesson from the past in organ biology.Cell Transplant,19(6): 645-647,2010
  29. Navarro-Alvarez N, Soto-Gutierrez A, Chen Y, Caballero-Corbalan J, Hassan W, Kobayashi S, Kondo Y, Iwamuro M, Yamamoto K, Kondo E, Tanaka N, Fox IJ, Kobayashi N: Intramuscular transplantation of engineered hepatic tissue constructs corrects acute and chronic liver failure in mice.J Hepatol,52(2): 211-219,2010
  30. Zhang J, Takahashi HK, Liu K, Wake H, Liu R, Sadamori H, Matsuda H, Yagi T, Yoshino T, Mori S, Nishibori M: Histamine inhibits adhesion molecule expression in human monocytes, induced by advanced glycation end products, during the mixed lymphocyte reaction.Br J Pharmacol, 160(6): 1378-1386,2010
  31. Takahashi HK, Zhang J, Mori S, Liu K, Wake H, Liu R, Sadamori H, Matsuda H, Yagi T, Yoshino T, Nishibori M:Prostaglandin E2 inhibits advanced glycation end product-induced adhesion molecule expression on monocytes, cytokine production, and lymphocyte proliferation during human mixed lymphocyte reaction.J Pharmacol Exp Ther,334(3): 964-972,2010
  32. Kitamura Y, Yagi T, Kitagawa K, Shinomiya K, Kawasaki H, Asanuma M, Gomita Y:Effects of bupropion on the forced swim test and release of dopamine in the nucleus accumbens in ACTH-treated rats.Naunyn Schmiedebergs Arch Pharmacol,382(2): 151-158,2010
  33. Yumoto Y, Yagi T, Sato S, Nouso K, Kobayashi Y, Ohmoto M, Yumoto E, Nagaya I, Nakatsukasa H:Preoperative estimation of remnant hepatic function using fusion images obtained by (99m)Tc-labelled galactosyl-human serum albumin liver scintigraphy and computed tomography.Br J Surg,97(6): 934-944,2010

2009年

  1. Ouchi M, Kawamura H, Urata Y, Fujiwara T:Antiviral activity of cidofovir against telomerase-specific replication-selective oncolytic adenovirus, OBP-301 (Telomelysin). Invest New Drugs,27: 241-245,2009
  2. Watanabe N, Ootawa Y, Kodama K, Kaide A, Ootsuka N, Matsuoka J:Concurrent administration of chemo-endocrine therapy for postmenopausal breast cancer patients.Breast Cancer, 2009
  3. Sakurama K, Noma K, Takaoka M, Tomono Y, Watanabe N, Hatakeyama S, Ohmori O, Hirota S, Motoki T, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Tanaka N, Naomoto Y:Inhibition of focal adhesion kinase as a potential therapeutic strategy for imatinib-resistant gastrointestinal stromal tumor. Mol Cancer Ther,8(1): 127-134,2009
  4. Tabuchi Y, Matsuoka J, Gunduz M, Imada T, Ono R, Ito M, Motoki T, Yamatsuji T, Shirakawa Y, Takaoka M, Haisa M, Tanaka N, Kurebayashi J, Jordan VC, Naomoto Y:Resistance to paclitaxel therapy is related with Bcl-2 expression through an estrogen receptor mediated pathway in breast cancer. Int J Oncol,34(2): 313-319,2009
  5. Sadamori H, Yagi T, Iwagaki H, Matsuda H, Shinoura S, Umeda Y, Ohara N, Yanai H, Ogino T, Tanaka N:Immunohistochemical staining of liver grafts with a monoclonal antibody against HCV-Envelope 2 for recurrent hepatitis C after living donor liver transplantation.J Gastroenterol Hepatol,24(4): 574-580,2009
  6. Ikeda Y, Kojima T, Kuroda S, Endo Y, Sakai R, Hioki M, Kishimoto H, Uno F, Kagawa S, Watanabe Y, Hashimoto Y, Urata Y, Tanaka N, Fujiwara T:A novel antiangiogenic effect for telomerase-specific virotherapy through host immune system. J Immunol,182: 1763-1769,2009
  7. Umeda Y, Iwagaki H, Ozaki M, Ogino T, Iwamoto T, Yoshida R, Shinoura S, Matsuda H, Sadamori H, Tanaka N, Yagi T:Refractory response to growth factors impairs liver regeneration after hepatectomy in patients with viral hepatitis.Hepatogastroenterology,56(93): 971-977,2009
  8. Kojima T, Hashimoto Y, Watanabe Y, Kagawa S, Uno F, Kuroda S, Tazawa H, Kyo S, Mizuguchi H, Urata Y, Tanaka N, Fujiwara T:A simple biological imaging system for detecting viable human circulating tumor cells. J Clin Invest,119: 3172-3181,2009
  9. Kamo N, Naomoto Y, Shirakawa Y, Yamatsuji T, Hirota S, Fujiwara Y, Noma K, Sakurama K, Takaoka M, Nagatsuka H, Gunduz M, Matsuoka J, Tanaka N:Involvement of focal adhesion kinase in the progression and prognosis of gastrointestinal stromal tumors.Hum Pathol,40(11): 1643-1649,2009
  10. Hanazaki M, Takata K, Goto K, Katayama H, Yokoyama M, Morita K, Shirakawa Y, Yamatsuji T, Naomoto Y:Anesthetic management of a patient with Alport-leiomyomatosis syndrome.J Anesth,23(3):453-455,2009
  11. Mita Y, Yasuda Y, Sakai A, Yamamoto H, Toyooka S, Gunduz M, Tanabe S, Naomoto Y, Ouchida M, Shimizu K:Missense polymorphisms of PTPRJ and PTPN13 genes affect susceptibility to a variety of human cancers.J Cancer Res Clin Oncol,136(2): 249-259, 2009
  12. Matsuo N, Shiraha H, Fujikawa T, Takaoka N, Ueda N, Tanaka S, Nishina S, Nakanishi Y, Uemura M, Takaki A, Nakamura S, Kobayashi Y, Nouso K, Yagi T, Yamamoto K:Twist expression promotes migration and invasion in hepatocellular carcinoma.BMC Cancer,9: 240, 2009
  13. Kato H, Kawamoto H, Tsutsumi K, Harada R, Fujii M, Hirao K, Kurihara N, Mizuno O, Ishida E, Ogawa T, Fukatsu H, Yamamoto K, Yagi T:Long-term outcomes of endoscopic management for biliary strictures after living donor liver transplantation with duct-to-duct reconstruction.Transpl Int,22(9): 914-921,2009
  14. Ohashi K, Takahashi HK, Mori S, Liu K, Wake H, Sadamori H, Matsuda H, Yagi T, Yoshino T, Nishibori M, Tanaka N:Advanced glycation end products enhance monocyte activation during human mixed lymphocyte reaction.Clin Immunol,134(3): 345-353, 2009
  15. Kishimoto H, Zhao M, Hayashi K, Urata Y, Tanaka N, Fujiwara T, Penman S, Hoffman RM:In vivo internal tumor illumination by telomerase-dependent adenoviral GFP for precise surgical navigation.Proc Natl Acad Sci USA,106: 14514-14517,2009
  16. Kishimoto H, Urata Y, Tanaka N, Fujiwara T, Hoffman RM:Selective metastatic tumor labeling with green fluorescent protein and killing by systemic administration of telomerase-dependent adenoviruses.Mol Cancer Ther,8: 3001-3008,2009
  17. Kominami K, Nagasaka T, Cullings HM, Hoshizima N, Sasamoto H, Young J, Leggett BA, Tanaka N, Matsubara N:Methylation in p14(ARF) is frequently observed in colorectal cancer with low-level microsatellite instability.J Int Med Res,37(4): 1038-1045,2009
  18. Sakurama K, Naomoto Y, Ohara T, Watanabe N, Takaoka M, Nagatsuka H, Tomono Y, Tanida T, Noma K, Tanabe S, Fujiwara Y, Motoki T, Shirakawa Y, Yamatsuji T, Hirota S, Taguchi T, Tanaka N:Establishment of a lymph node metastasis model from subcutaneous tumors of gastrointestinal stromal tumor model cells.Oncol Rep,21(2): 407-411,2009
  19. Basma Hesham, Soto-Gutierrez Alejandro, Yannam Govardhana Rao, Liu Liping, Ito R, Yamamoto T, Ellis Ewa, Carson Steven D, Sato S, Chen Yong, Muirhead David, Navarro-Alvarez Nalu, Wong Ronald J, Roy-Chowdhury Jayanta, Platt  Jeffrey L,Mercer David F,Miller John D, Strom Stephen C,Kobayashi N,Fox Ira J:Differentiation and transplantation of human embryonic stem cell-derived hepatocytes.Gastroenterology, 136(3): 990-999,2009
  20. Matsumoto S, Noguchi H,Hatanaka N, Shimoda M,Kobayashi N,Jackson Andrew, Onaca Nicholas,Naziruddin, Bashoo, Levy Marlon F:SUITO index for evalutation of efficacy of single donor islet transplantation.Cell Transplantation,18(5-6): 557-562,2009
  21. Matsumoto S, Noguchi H, Hatanaka N, Shimoda M, Kobayashi N, Jackson A, Onaca N, Naziruddin B, Levy MF:Estimation of donor usability for islet transplantation in the United States with the Kyoto islet isolation method.Cell Transplantation,18(5-6): 549-556, 2009
  22. Nakahara H, Misawa H,Hayashi T,Kondo E,Yuasa T,Kubota Y,Seita M,Kawamoto H,Hassan Wael Amgad Refaat Ahmed,Hassan Reham Amgad Refaat Ahmed,Javed Shahid Muhammad,Tanaka M,Endo H,Noguchi H,Matsumoto S,Takata K,Tashiro Y,Nakaji S,Ozaki T,Kobayashi N:Bone repair by transplantation of hTERT-immortalized human mesenchymal stem cells in mice.Transplantation,88(3): 346-353,2009
  23. Nishie M, Tateno C, Utoh R, Kohashi T, Masumoto N, Kobayashi N, Itamoto T, Tanaka N, Asahara T, Yoshizato K:Hepatocytes from fibrotic liver possess high growth potential in vivo.Cell Transplantation, 18(5-6): 665-675,2009
  24. Noguchi H, Matsumoto S, Onaca N, Naziruddin B, Jackson A, Ikemoto T, Shimoda M, Fujita Y, Chujo D, Iwanaga Y, Nagata H, Okitsu T, Kobayashi N, Ueno H, Chaussabel D, Grayburn P, Banchereau J, Levy MF:Ductal injection of JNK inhibitors before pancreas preservation prevents islet apoptosis and improves islet graft function.Human Gene Therapy,20(1): 73-85,2009
  25. Noguchi H, Ikemoto T, Naziruddin B, Jackson A, Shimoda M, Fujita Y, Chujo D, Takita M, Kobayashi N, Onaca N, Levy MF, Matsumoto S:Iodixanol-controlled density gradient during islet purification improves recovery rate in human islet isolation.Transplantation,87(11): 1629-1635,2009
  26. Noguchi H, Oishi K, Ueda M, Yukawa H, Hayashi S, Kobayashi N, Levy MF, Matsumoto S:Establishment of mouse pancreatic stem cell line.Cell Transplantation, 18(5-6): 563-571,2009
  27. Noguchi H, Ueda M, Hayashi S, Kobayashi N, Okitsu T, Iwanaga Y, Nagata H, Liu X, Kamiya H, Levy MF, Matsumoto S:Comparison of trypsin inhibitors in preservation solution for islet isolation.Cell Transplantation,18(5-6): 541-547,2009
  28. Yuasa T, Rivas-Carrillo JD, Navarro-Alvarez N, Soto-Gutierrez A, Kubota Y, Tabata Y, Okitsu T, Noguchi H, Matsumoto S, Nakaji S, Tanaka N, Kobayashi N:Neovascularization induced around an artificial device implanted in the abdomen by the use of gelatinized fibroblast growth factor 2.Cell Transplantation,18(5-6): 683-688,2009
  29. Kobayashi N:Life support of artificial liver:development of a bioartificial liver to treat liver failure.Journal of Hepato-biliary-pancreatic Surgery,16(2): 113-117,2009
  30. Kobayashi N, Yuasa T, Okitsu T:Regenerative medicine for diabetes mellitus.Cell Transplantation,18(5-6): 491-496,2009
  31. Noguchi H, Levy Marlon F,Kobayashi N, Matsumoto S:Pancreas preservation by the Two-Layer Method: Does it have a beneficial effect compared with simple preservation in University of Wisconsin solution? Cell Transplantation,18(5-6): 497-503,2009
  32. Navarro-Alvarez Nalu, Soto-Gutierrez Alejandro,Kobayashi N:Stem cell research and therapy for liver disease.Current Stem Cell Research & Therapy,4(2): 141-146,2009
  33. Chan-On Waraporn, Kuwahara K, Kobayashi N, Ohta K, Shimasaki T, Sripa B, Leelayuwat C, Sakaguchi N:Cholangiocarcinomas associated with long-term inflammation express the activation-induced cytidine deaminase and germinal center-associated nuclear protein involved in immunoglobulin V-region diversification.International Journal of Oncology,35(2): 287-295,2009
  34. Takahashi HK, Mori S, Wake H, Liu K, Yoshino T, Ohashi K, Tanaka N, Shikata K, Makino H, Nishibori M:Advanced glycation end products subspecies-selectively induce adhesion molecule expression and cytokine production in human peripheral blood mononuclear cells.J Pharmacol Exp Ther,330(1): 89-98,2009
  35. Nagasaka T, Tanaka N, Cullings HM, Sun DS, Sasamoto H, Uchida T, Koi M, Nishida N, Naomoto Y, Boland CR, Matsubara N, Goel A:Analysis of fecal DNA methylation to detect gastrointestinal neoplasia.J Natl Cancer Inst,101(18): 1244-1258,2009
  36. Nishibori M, Takahashi HK, Katayama H, Mori S, Saito S, Iwagaki H, Tanaka N, Morita K, Ohtsuka A:Specific Removal of Monocytes from Peripheral Blood of Septic Patients by Polymyxin B-immobilized Filter Column. Acta Med Okayama,63(1): 65-69,2009
  37. Hao HF, Naomoto Y, Bao XH, Watanabe N, Sakurama K, Noma K, Tomono Y, Fukazawa T, Shirakawa Y, Yamatsuji T, Matsuoka J, Takaoka M:Progress in researches about focal adhesion kinase in gastrointestinal tract.World J Gastroenterol,15(47): 5916-5923,2009
  38. Fukazawa T, Fukazawa T, Maeda Y, Matsuoka J, Tanaka N, Tanaka H, Durbin ML, Naomoto Y:Drug-regulatable cancer cell death induced by BID under control of the tissue-specific, lung cancer-targeted TTS promoter system.Int J Cancer,125(8): 1975-1984,2009
  39. Domae S, Nakamura Y, Nakamura Y, Uenaka A, Wada H, Nakata M, Oka M, Kishimoto K, Tsukamoto G, Yoshihama Y, Matsuoka J, Gochi A, Kohno S, Saika T, Sasaki A, Nakayama E, Ono T:Identification of CCDC62-2 as a novel cancer/testis antigen and its immunogenicity.Int J Cancer,124(10): 2347-2352,2009
  40. Sadamori H, Matsuda H, Shinoura S, Umeda Y, Yoshida R, Sato D, Utsumi H, Ohnishi T, Yagi T:Anatomical subsegmentectomy in the lateral segment for hepatocellular carcinoma.Hepatogastroenterology,56(94-95): 1511-1515,2009
  41. Nakajima O, Matsunaga A, Ichimaru D, Urata Y, Fujiwara T, Kawakami K:Telomerase-specific virotherapy in an animal model of human head and neck cancer. Mol Cancer Ther,8: 171-177,2009
  42. Kurihara Y, Watanabe Y, Onimatsu H, Kojima T, Shirota T, Hatori M, Liu D, Kyo S, Mizuguchi H, Urata Y, Shintani S, Fujiwara T:Telomerase-specific virotheranostics for human head and neck cancer.Clin Cancer Res,15: 2335-2343,2009
  43. Liu D , Kojima, T, Ouchi, M, Kuroda, S, Watanabe, Y, Hashimoto, Y, Onimatsu, H, Urata, Y, Fujiwara, T:Preclinical evaluation of synergistic effect of telomerase-specific oncolytic virotherapy and gemcitabine for human lung cancer.Mol Cancer Ther,8: 980-987,2009
  44. Takakura M , Nakamura M, Kyo S, Hashimoto M, Mori N, Ikoma T, Mizumoto Y, Fujiwara T, Urata Y, Inoue M: Intraperitoneal administration of telomerase-specific oncolytic adenovirus sensitizes ovarian cancer cells to cisplatin and affects survival in a xenograft model with peritoneal dissemination.Cancer Gene Ther,2009
  45. Nemunaitis J, Tong AW, Nemunaitis M, Senzer N, Phadke A P, Bedell C, Adams N, Zhang Y A, Maple PB, Chen S, Pappen B, Burke J, Ichimaru D, Urata Y, Fujiwara T: A phase I study of telomerase-specific replication competent oncolytic adenovirus (Telomelysin) for various solid tumors. Mol Ther, 18(2): 429-34,2009
  46. Matsumoto S, Noguchi H,Shimoda M,Ikemoto T,Naziruddin, Bashoo, Jackson Andrew,Tamura Y, Olson G, Fujita Y, Chujo D, Takita M, Kobayashi N,Onaca N, Levy M:Seven consecutive successful clinical islet isolations with pancreatic ductal injection.Cell Transplantation,2009
  47. Hao H, Naomoto Y, Bao X, Watanabe N, Sakurama K, Noma K, Motoki T, Tomono Y, Fukazawa T, Shirakawa Y, Yamatsuji T, Matsuoka J, Wang ZG, Takaoka M:Focal adhesion kinase as potential target for cancer therapy (Review).Oncol Rep,22(5): 973-979,2009
  48. Fujiwara Y, Naomoto Y, Tanabe S, Sakurama K, Noma K, Nishikawa T, Motoki T, Takaoka M, Shirakawa Y, Yamatsuji T, Matsuoka J: A case report of FOLFOX treatment for primary duodenal carcinoma with multiple liver metastases. Gan To Kagaku Ryoho, 36(4): 655-657,2009
  49. Nakagawa H, Nagasaka T, Cullings HM, Notohara K, Hoshijima N, Young J, Lynch HT, Tanaka N, Matsubara N:Efficient molecular screening of Lynch syndrome by specific 3' promoter methylation of the MLH1 or BRAF mutation in colorectal cancer with high-frequency microsatellite instability. Oncol Rep,21(6): 1577-1583,2009
  50. Fujiwara T: Telomerase-specific virotherapy for human squamous cell carcinoma.Expert Opin Biol Ther,9: 321-329,2009
  51. Watanabe Y, Kojima T, Kagawa S, Uno F, Hashimoto Y, Kyo S, Mizuguchi H, Tanaka N, Kawamura H, Ichimaru D, Urata Y, Fujiwara T:A novel translational approach for human malignant pleural mesothelioma: heparanase-assisted dual virotherapy.Oncogene, 29(8): 1145-1154,2009
  52. Maida Y, Kyo S, Sakaguchi J, Mizumoto Y, Hashimoto M, Mori N, Ikoma T, Nakamura M, Takakura M, Urata Y, Fujiwara T, Inoue M:Diagnostic potential and limitation of imaging cancer cells in cytological samples using telomerase-specific replicative adenovirus.Int J Oncol,34: 1549-1556,2009
  53. Nakajima O, Ichimaru D, Urata Y, Fujiwara T, Horibe T, Kohno M, Kawakami K: Use of telomelysin (OBP-301) in mouse xenografts of human head and neck cancer. Oncol Rep,22: 1039-1043,2009
  54. Vilkin A, Niv Y, Nagasaka T, Morgenstern S, Levi Z, Fireman Z, Fuerst F, Goel A, Boland CR:Microsatellite instability, MLH1 promoter methylation, and BRAF mutation analysis in sporadic colorectal cancers of different ethnic groups in Israel.Cancer, 115(4): 760-769,2009
  55. Egi M, Toda Y, Katayama H, Yokoyama M, Morita K, Arai H, Yamatsuji T, Bailey M, Naomoto Y:Safer glycemic control using isomaltulose-based enteral formula: A pilot randomized crossover trial.  J Crit Care,25(1): 90-96,2009
  56. Link A, Shin SK, Nagasaka T, Balaguer F, Koi M, Jung B, Boland CR, Goel A JC: virus mediates invasion and migration in colorectal metastasis.PLoS One, 4(12): e8146,2009

2008年

  1. Iwamoto T, Yagi T, Umeda Y, Sato D, Matsukawa H, Matsuda H, Shinoura S, Sadamori H, Mizuno K, Yoshida R, Tanaka N:The impact of donor age on the outcome of adult living donor liver transplantation.Transplantation, 85(9): 1240-1245, 2008
  2. Yuasa T, Yamamoto T, Rivas-Carrillo JD, Chen Y, Navarro-Alvarez N, Soto-Guiterrez A, Noguchi H, Matsumoto S, Tanaka N, Kobayashi N:Laparoscopy-assisted creation of a liver failure model in pigs.Cell Transplant, 17(1-2): 187-193, 2008
  3. Navarro-Alvarez N, Rivas-Carrillo JD, Soto-Gutierrez A, Yuasa T, Okitsu T, Noguchi H, Matsumoto S, Takei J, Tanaka N, Kobayashi N:Reestablishment of microenvironment is necessary to maintain in vitro and in vivo human islet function.Cell Transplant, 17(1-2): 111-119, 2008
  4. Navarro-Alvarez N, Soto-Gutierrez A, Yuasa T, Yamatsuji T, Shirakawa Y, Nagasaka T, Sun SD, Javed MS, Tanaka N, Kobayashi N:Long-term culture of Japanese human embryonic stem cells in feeder-free conditions.Cell Transplant, 17(1-2): 27-33, 2008
  5. Kobayashi N, Navarro-Alvarez N, Soto-Gutierrez A, Kawamoto H, Kondo Y, Yamatsuji T, Shirakawa Y, Naomoto Y, Tanaka N:Cancer stem cell research: current situation and problems.Cell Transplant, 17(1-2): 19-25, 2008
  6. Soto-Gutierrez A, Navarro-Alvarez N, Caballero-Corbalan J, Tanaka N, Kobayashi N: Endoterm induction for hepatic and pancreatic differentiation of ES cells.Acta Med Okayama, 62(2): 63-68, 2008
  7. Murata T, Naomoto Y, Yamatsuji T, Okawa T, Shirakawa Y, Gunduz M, Nobuhisa T, Takaoka M, Sirmali M, Nakajima M, Ohno Y, Tanaka N:Localization of FAK is related with colorectal carcinogenesis.Int J Oncol, 32(4): 791-796, 2008
  8. Nakagawa Y, Uemura S, Nakaoka T, Yano T, Tanaka N:Evaluation of the Nuss procedure using pre- and postoperative computed tomographic index.J Pediatr Surg, 43(3): 518-521, 2008
  9. Hioki M, Kagawa S, Fujiwara T, Sakai R, Kojima T, Watanabe Y, Hashimoto Y, Uno F, Tanaka N, Fujiwara T:Combination of oncolytic adenovirotherapy and Bax gene therapy in human cancer xenografted models. Potential merits and hurdles for combination therapy.Int J Cancer, 122(11): 2628-2633, 2008
  10. Nagasaka T, Goel A, Notohara K, Takahata T, Sasamoto H, Uchida T, Nishida N, Tanaka N, Boland CR, Matsubara N:Methylation pattern of the O6-methylguanine-DNA methyltransferase gene in colon during progressive colorectal tumorigenesis.Int J Cancer, 122(11): 2429-2436, 2008
  11. Sadamori H, Yagi T, Matsukawa H, Matsuda H, Shinoura S, Umeda Y, Iwamoto T, Satoh D, Tanaka N:The outcome of living donor liver transplantation with prior spontaneous large portasystemic shunts.Transpl Int, 21(2): 156-162, 2008
  12. Endo Y, Sakai R, Ouchi M, Onimatsu H, Hioki M, Kagawa S, Uno F, Watanabe Y, Urata Y, Tanaka N, Fujiwara T:Virus-mediated oncolysis induces danger signal and stimulates cytotoxic T-lymphocyte activity via proteasome activator upregulation.Oncogene, 27(17): 2375-2381, 2008
  13. Fujiwara T, Urata Y, Tanaka N:Diagnostic and therapeutic application of telomerase-specific oncolytic adenoviral agents.Front Biosci, 13: 1881-1886, 2008
  14. Hamano R, Takahashi HK, Iwagaki H, Kanke T, Liu K, Yoshino T, Sendo T, Nishibori M, Tanaka N:Stimulation of adenosine A2A receptor inhibits LPS-induced expression of intercellular adhesion molecule 1 and production of TNF-alpha in human peripheral blood mononuclear cells.Shock, 29(2): 154-159, 2008
  15. Matsusaki T, Morimatsu H, Takahashi T, Matsumi M, Sato K, Kaku R, Sato T, Yagi T, Tanaka N, Morita K:Increased exhaled carbon monoxide concentration during living donor liver transplantation.Int J Mol Med, 21(1): 75-81, 2008
  16. Sadamori H, Yagi T, Matsukawa H, Matsuda H, Shinoura S, Umeda Y, Narushima M, Tanaka N:Successful re-transection of conglutinated hepatic resection plane for repeated systematized hepatectomy. Hepatogastroenterology, 55(82-83): 363-366, 2008
  17. Watanabe N, Takaoka M, Sakurama K, Tomono Y, Hatakeyama S, Ohmori O, Motoki T, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Beer DG, Nagatsuka H, Tanaka N, Naomoto Y: Dual tyrosine kinase inhibitor for focal adhesion kinase and insulin-like growth factor-I receptor exhibits anticancer effect in esophageal adenocarcinoma in vitro and in vivo.Clin Cancer Res, 14(14): 4631-4639, 2008
  18. Ono R, Matsuoka J, Yamatsuji T, Naomoto Y, Tanaka N, Matsui H, Matsushita M:M-RIP, a novel target of JNK signaling and a requirement for human cancer cell invasion.Int J Mol Med, 22(2):199-203, 2008
  19. Fukazawa T, Matsuoka J, Naomoto Y, Maeda Y, Durbin ML, Tanaka N:Malignant pleural mesothelioma-targeted CREBBP/EP300 inhibitory protein 1 promoter system for gene therapy and virotherapy. Cancer Res, 68(17): 7120-7129, 2008
  20. Yoshida R, Iwamoto T, Yagi T, Sato D, Umeda Y, Mizuno K, Shinoura S, Matsukawa H, Matsuda H, Sadamori H, Tanaka N:Preoperative Assessment of the Risk Factors that Help to Predict the Prognosis After Living Donor Liver Transplantation.World J Surg, 32(11): 2419-2424, 2008
  21. Umeda Y, Yagi T, Sadamori H, Matsukawa H, Matsuda H, Shinoura S, Mizuno K, Yoshida R, Iwamoto T, Satoh D, Tanaka N:Effects of prophylactic splenic artery modulation on portal overperfusion and liver regeneration in small-for-size graft.Transplantation, 86(5): 673-680, 2008
  22. Hashimoto Y, Watanabe Y, Shirakiya Y, Uno F, Kagawa S, Kawamura H, Nagai K, Tanaka N, Kumon H, Urata Y, Fujiwara T:Establishment of biological and pharmacokinetic assays of telomerase-specific replication-selective adenovirus.Cancer Sci, 99(2): 385-390, 2008
  23. Otani S, Kuinose M, Murakami T, Saito S, Iwagaki H, Tanaka N, Tanemoto K:Preoperative oral administration of pentoxifylline ameliorates respiratory index after cardiopulmonary bypass through decreased production of IL-6.Acta Med Okayama, 62(2): 69-74, 2008
  24. Noma K, Smalley KS, Lioni M, Naomoto Y, Tanaka N, El-Deiry W, King AJ, Nakagawa H, Herlyn M:The essential role of fibroblasts in esophageal squamous cell carcinoma-induced angiogenesis. Gastroenterology, 134(7): 1981-1993, 2008
  25. Rivera RS, Nagatsuka H, Siar CH, Gunduz M, Tsujigiwa H, Han PP, Katase N, Tamamura R, Ng KH, Naomoto Y, Nakajima M, Nagai N:Heparanase and vascular endothelial growth factor expression in the progression of oral mucosal melanoma.Oncol Rep , 9(3): 657-661, 2008
  26. Fukatsu H, Kawamoto H, Harada R, Fujii M, Tsutsumi K, Ogawa T, Ishida E, Okada H, Sakaguchi K, Yagi T, Matsukawa H, Sadamori H, Ohmori M:Cholesterolosis of the common bile duct with anomalous arrangement of the pancreaticobiliary ductal system.Gastrointest Endosc, 67(7): 1172-1173, 2008
  27. Matsusaki T, Morimatsu H, Takahashi T, Matsumi M, Sato K, Kaku R, Sato T, Yagi T, Tanaka N, Morita K:Increased exhaled carbon monoxide concentration during living donor liver transplantation.Int J Mol Med, 21(1): 75-81, 2008
  28. Takaki A, Suzuki H, Iwasaki Y, Takigawa T, Ogino K, Matsuda H, Yagi T, Hanazaki M, Nakatsuka H, Katayama H, Matsumi M, Shoji B, Terada R, Kobashi H, Sakaguchi K: A 27-year-old man who died of acute liver failure probably due to trichloroethylene abuse.J Gastroenterol, 43(3): 239-242, 2008
  29. Ohara T, Oto T, Miyoshi K, Tao H, Yamane M, Toyooka S, Okazaki M, Date H, Sano Y:Sirolimus ameliorated post lung transplant chylothorax in lymphangioleiomyomatosis.Ann Thorac Surg, 86(6): e7-8, 2008
  30. Yoshida R, Iwamoto T, Yagi T, Sato D, Umeda Y, Mizuno K, Shinoura S, Matsukawa H, Matsuda H, Sadamori H, Tanaka N.:Preoperative assessment of the risk factors that help to predict the prognosis after living donor liver transplantation.World J Surg, 32(11): 2419-2424, 2008
  31. Naoya Kobayashi:Artificial cells for the development of cell therapy. Cell Transplantation, 17(1-2): 3-9, 2008
  32. Naoya Kobayashi:Bioartificial pancreas for the treatment of diabetes.Cell Transplantation, 17(1-2): 11-17, 2008
  33. Hirofumi Noguchi, Michiko Ueda, Shuji Hayashi, Naoya Kobayashi, Teru Okitsu, Yasuhiro Iwanaga, Hideo Nagata, Yusuke Nakai, Shinichi Matsumoto:Ductal injection of preservation solution increases islet yields in islet isolation and improves islet graft function.Cell Transplantation, 17(1-2): 69-81, 2008
  34. Michiko Ueda, Shinichi Matsumoto, Shuji Hayashi, Naoya Kobayashi, Hirofumi Noguchi:Cell surface heparan sulfate proteoglycans mediate the internalization of PDX-1 protein.Cell Transplantation, 17(1-2): 91-97, 2008
  35. Hirofumi Noguchi, Yuichiro Yamada, Teru Okitsu, Yasuhiro Iwanaga, Hideo Nagata, Naoya Kobayashi, Shuji Hayashi, Shinichi Matsumoto:Secretory unit of islet in transplantation (SUIT) and engrafted islet rate (EIR) indexes are useful for evaluating single islet transplantation. Cell Transplantation, 17(1-2): 121-128, 2008
  36. Masahiro Ito, Ryoutaro Ito, Daisuke Yoshihara, Masashi Ikeno, Megumi Kamiya, Nobutaka Suzuki, Akihiko Horiguchi, Hideo Nagata, Toshiyuki Yamamoto, Naoya Kobayashi, Ira J. Fox, Tsuneko Okazaki, Syuichi Miyakama: Immortalized hepatocytes using human artificial chromosome.Cell Transplantation, 17(1-2): 165-171, 2008
  37. Naoya Kobayashi:The current status of islet transplantation and its perspectives. Review of diabetic studies, 5(3): 136-143, 2008
  38. Naoya Kobayashi:Life support of artificial liver: development of a bioartificial liver to treat liver failure.Journal of hepato-biliary-pancreatic surgery, 2008
  39. Naoya Kobayashi, Nalu Navarro-Alvarez, Alejandro Soto-Gutierrez, Hironobu Kawamoto, Yoshitaka Kondo, Tomoki Yamatsuji, Yasuhiro Shirakawa, Yoshio Naomoto, Noriaki Tanaka: Cancer stem cell research: current situation and problems.Cell Transplantation, 17(1-2): 19-25, 2008
  40. Nalu Navarro-Alvarez, Alejandro Soto-Gutierrez, Takeshi Yuasa, Tomoki Yamatsuji, Yasuhiro Shirakawa, Takeshi Nagasaka, Sheng Sun D., Muhammad Shahid Javed, Noriaki Tanaka, Naoya Kobayashi: Long-term culture of Japanese human embryonic stem cells in feeder-free conditions. Cell Transplantation, 17(1-2): 27-33, 2008
  41. Nalu Navarro-Alvarez, Jorge David Rivas-Carrillo, Alejandro Soto-Gutierrez, Takeshi Yuasa, Teru Okitsu, Hirofumi Noguchi, Shinichi Matsumoto, Jiro Takei, Noriaki Tanaka, Naoya Kobayashi:Reestablishment of microenvironment is necessary to maintain in vitro and in vivo human islet function. Cell Transplantation, 17(1-2): 111-119, 2008
  42. Takeshi Nagasaka, Minoru Koi, Matthias Kloor, Johannes Gebert, Alex Vilkin, Naoshi Nishida, Sung Kwan Shin, Hiromi Sasamoto, Noriaki Tanaka, Nagahide Matsubara, C. Richard Boland, and Ajay Goel:Mutations in both KRAS and BRAF contribute to the methylator phenotype in colon cancer.Gastroenterology, 134: 1950-1960, 2008
  43. Huang P, Watanabe M, Kaku H, Kashiwakura Y, Chen J, Saika T, Nasu Y, Fujiwara T, Urata Y, Kumon H:Direct and distant antitumor effects of a telomerase-selective oncolytic adenoviral agent, OBP-301, in a mouse prostate cancer model. Cancer Gene Ther, 15: 315-322, 2008
  44. Yokoyama T, Iwado E, Kondo Y, Aoki H, Hayashi Y, Georgescu M M, Sawaya R, Hess K R, Mills G B, Kawamura H, Hashimoto Y, Urata Y, Fujiwara T, Kondo S: Autophagy-inducing agents augment the antitumor effect of telerase-selve oncolytic adenovirus OBP-405 on glioblastoma cells. Gene Ther, 15: 1233-1239, 2008
  45. Kyo S, Takakura M, Fujiwara T, Inoue M:Understanding and exploiting hTERT promoter regulation for diagnosis and treatment of human cancers. Cancer Sci, 99: 1528-1538, 2008
  46. Ouchi M, Kawamura H, Urata Y, Fujiwara T:Antiviral activity of cidofovir against telomerase-specific replication-selective oncolytic adenovirus, OBP-301 (Telomelysin). Invest New Drug, 27(3): 241-245, 2008
  47. Ikeda Y, Kojima T, Kuroda S, Endo Y, Sakai R, Hioki M, Kishimoto H, Uno F, Kagawa S, Watanabe Y, Hashimoto Y, Urata Y, Tanaka N, Fujiwara T:A novel antiangiogenic effect for telomeras-specific virotherapy through host immune system. J Immunol, 182(3): 1763-1769, 2008
  48. Nakajima O, Matsunaga A, Ichimaru D, Urata Y, Fujiwara T, Kawakami K. Mol:Telomerase-specific virotherapy in animal model of human head and neck cancer.  Mol Cancer Ther, 8(1): 171-177, 2008
  49. Maida Y, Kyo S, Sakaguchi J, Mizumoto Y, Hashimoto M, Mori N, Ikoma T, Takakura M, Urata Y, Fujiwara T, Inoue M: Application of telomerase-specific replication-selective adenovirus to cytological diagnosis of gynecologic cancers.Int J Oncol, 34(6): 1549-1556, 2008
  50. Wang ZG, Fukazawa T, Nishikawa T, Watanabe N, Sakurama K, Motoki T, Takaoka M, Hatakeyama S, Omori O, Ohara T, Tanabe S, Fujiwara Y, Shirakawa Y, Yamatsuji T, Tanaka N, Naomoto Y:TAE226, a dual inhibitor for FAK and IGF-IR, has inhibitory effects on mTOR signaling in esophageal cancer cells. Oncol Rep, 20(6): 1473-1477, 2008
  51. Haugen AC, Goel A, Yamada K, Marra G, Nguyen TP, Nagasaka T, Kanazawa S, Koike J, Kikuchi Y, Zhong X, Arita M, Shibuya K, Oshimura M, Hemmi H, Boland CR, Koi M. Genetic instability caused by loss of MutS homologue 3 in human colorectal cancer. Cancer Res, 68(20): 8465-8472, 2008
  52. Arnold CN, Nagasaka T, Goel A, Scharf I, Grabowski P, Sosnowski A, Schmitt-Gräff A, Boland CR, Arnold R, Blum HE. Molecular characteristics and predictors of survival in patients with malignant neuroendocrine tumors. Int J Cancer, 123(7): 1556-1564, 2008
  53. Nishida N, Nagasaka T, Nishimura T, Ikai I, Boland CR, Goel A. Aberrant methylation of multiple tumor suppressor genes in aging liver, chronic hepatitis, and hepatocellular carcinoma. Hepatology. 47(3): 908-18, 2008

2007年

  1. Rivas-Carrillo JD, Okitsu T, Tanaka N, Kobayashi N:Pancreas development and beta-cell differentiation of embryonic stem cells.  Curr Med Chem, 14(14): 1573-1578, 2007
  2. Totsugawa T, Yong C, Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Westerman KA, Kohara M, Reth M, Tanaka N, Leboulch P, Kobayashi N:Survival of liver failure pigs by transplantation of reversibly immortalized human hepatocytes with Tamoxifen-mediated self-recombination.J Hepatol, 47(1): 74-82, 2007
  3. Soto-Gutierrez A, Navarro-Alvarez N, Zhao D, Rivas-Carrillo JD, Lebkowski J, Tanaka N, Fox IJ, Kobayashi N:Differentiation of mouse embryonic stem cells to hepatocyte-like cells by co-culture with human liver nonparenchymal cell lines.Nat Protoc, 2(2): 347-356, 2007
  4. Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Noguchi H, Okitsu T, Chen Y, Yuasa T, Tanaka K, Narushima M, Miki A, Misawa H, Tabata Y, Jun HS, Matsumoto S, Fox IJ, Tanaka N, Kobayashi N:Cell-permeable pentapeptide V5 inhibits apoptosis and enhances insulin secretion, allowing experimental single-donor islet transplantation in mice.Diabetes, 56(5): 1259-1267, 2007
  5. Soto-Gutierrez A, Navarro-Alvarez N, Rivas-Carrillo JD, Tanaka K, Chen Y, Misawa H, Okitsu T, Noguchi H, Tanaka N, Kobayashi N:Construction and transplantation of an engineered hepatic tissue using a polyaminourethane-coated nonwoven polytetrafluoroethylene fabric.Transplantation, 83(2): 129-137, 2007
  6. Shinoda M, Tilles AW, Kobayashi N, Wakabayashi G, Takayanagi A, Totsugawa T, Harada H, Obara H, Suganuma K, Berthiaume F, Shimazu M, Shimizu N, Tanaka N, Kitajima M, Tompkins RG, Toner M, Yarmush ML:A bioartificial liver device secreting interleukin-1 receptor antagonist for the treatment of hepatic failure in rats.J Surg Res, 137(1): 130-140, 2007
  7. Nobuhisa T, Naomoto Y, Okawa T, Takaoka M, Gunduz M, Motoki T, Nagatsuka H, Tsujigiwa H, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Kurebayashi J, Nakajima M, Taniguchi S, Sagara J, Dong J, Tanaka N:Translocation of heparanase into nucleus results in cell differentiation.Cancer Sci, 98(4): 535-540, 2007
  8. Fukazawa T, Maeda Y, Durbin ML, Nakai T, Matsuoka J, Tanaka H, Naomoto Y, Tanaka N:Pulmonary adenocarcinoma-targeted gene therapy by a cancer- and tissue-specific promoter system.Mol Cancer Ther, 6(1): 244-252, 2007
  9. Naomoto Y, Gunduz M, Takaoka M, Okawa T, Gunduz E, Nobuhisa T, Kobayashi M, Shirakawa Y, Yamatsuji T, Sonoda R, Matsuoka J, Tanaka N:Heparanase promotes angiogenesis through Cox-2 and HIF1alpha.Med Hypotheses, 68(1): 162-165, 2007
  10. Teraishi F, Uno F, Kagawa S, Fujiwara T, Gouchi A, Tanaka N:Advanced gastric adenocarcinoma mimicking a submucosal tumor.Endoscopy, Suppl 1: E191-2, 2007
  11. Sato Y, Fujiwara T, Mine T, Shomura H, Homma S, Maeda Y, Tokunaga N, Ikeda Y, Ishihara Y, Yamada A, Tanaka N, Itoh K, Harada M, Todo S:Immunological evaluation of personalized peptide vaccination in combination with a 5-fluorouracil derivative (TS-1) for advanced gastric or colorectal carcinoma patients.Cancer Sci, 98(7): 1113-1119, 2007
  12. Kagawa S, Fujiwara T, Nishizaki M, Naomoto Y, Hiroshi I, Tanaka N:Adenomyoma of the stomach presenting as localized peritonitis.Dig Dis Sci, 52(11): 3184-3187, 2007
  13. Fujiwara T, Urata Y, Tanaka N:Telomerase-specific oncolytic virotherapy for human cancer with the hTERT promoter.  Curr Cancer Drug Targets, 7(2): 191-201, 2007
  14. Fujiwara T, Naomoto Y, Motoki T, Shigemitsu K, Shirakawa Y, Yamatsuji T, Kataoka M, Haisa M, Fujiwara T, Egi M, Morimatsu H, Hanazaki M, Katayama H, Morita K, Mizumoto K, Asou T, Arima H, Sasaki H, Matsuura M, Gunduz M, Tanaka N:Effects of a novel palatinose based enteral formula (MHN-01) carbohydrate-adjusted fluid diet in improving the metabolism of carbohydrates and lipids in patients with esophageal cancer complicated by diabetes mellitus.J Surg Res, 138(2): 231-240, 2007
  15. Matsumoto Y, Nagasaka T, Kambara T, Hoshizima N, Murakami J, Sasamoto H, Hosokawa M, Naomoto Y, Isozaki H, Shimizu K, Tanaka N, Matsubara N:Microsatellite instability and clinicopathological features in esophageal squamous cell cancer.Oncol Rep, 18(5): 1123-1127, 2007
  16. Kimura, K, Nagasaka, T, Sasamoto, H, Notohara, K, Takeda, M, Komnami, K, Ishii, T, Tanaka, N, Matsubara, N:No duplicate KRAS mutation is identified on the same allele of gastric or colorectal cancer cells with multiple KRAS mutations. J Int Med Res, 35(4): 450-457, 2007
  17. Murakami J, Lee YJ, Kokeguchi S, Tsujigiwa H, Asaumi J, Nagatsuka H, Fukui K, Kuroda M, Tanaka N, Matsubara N:Depletion of O6-methylguanine-DNA methyltransferase by O6-benzylguanine enhances 5-FU cytotoxicity in colon and oral cancer cell lines.Oncol Rep, 17(6): 1461-1467, 2007
  18. Ishii T, Murakami J, Notohara K, Cullings HM, Sasamoto H, Kambara T, Shirakawa Y, Naomoto Y, Ouchida M, Shimizu K, Tanaka N, Jass JR, Matsubara N:Oesophageal squamous cell cancer may develop within a background of accumulating DNA methylation in normal and dysplastic mucosa.Gut, 56: 13-19, 2007
  19. Oyama T, Sadamori H, Matsukawa H, Murata H, Umeda Y, Watanabe Y, Ozaki M, Iwagaki H, Tanaka N, Yagi T:Small liver graft regenerates through immediate increase of HGF and IL-6--possible involvement of sinusoidal tensile/shear stress in small liver graft.Hepatogastroenterology, 54(79): 2078-2083, 2007
  20. Takahashi HK, Iwagaki H, Hamano R, Wake H, Kanke T, Liu K, Yoshino T, Tanaka N, Nishibori M:Effects of adenosine on adhesion molecule expression and cytokine production in human PBMC depend on the receptor subtype activated.Br J Pharmacol, 150(6): 816-822, 2007
  21. Umeda Y, Umeda Y, Yagi T, Sadamori H, Matsukawa H, Matsuda H, Shinoura S, Iwamoto T, Satoh D, Iwagaki H, Tanaka N:Preoperative proximal splenic artery embolization: a safe and efficacious portal decompression technique that improves the outcome of live donor liver transplantation.Transpl Int, 20(11): 947-955, 2007
  22. Takahashi HK , Kanke T, Liu K, Yoshino T, Sendo T, Tanaka N, Nishibori M:Adenosine A2A-receptor stimulation inhibits lipopolysaccharide-induced interleukin-18 production in monocytes.J Pharmacol Sci, 104(2): 183-186, 2007
  23. Takahashi HK, Iwagaki H, Yagi T, Kanke T, Liu K, Yoshino T, Tanaka N, Nishibori M:Action profiles of statins and calcineurin inhibitors during human mixed lymphocyte reaction.Clin Immunol, 123(3): 324-332, 2007
  24. Takahashi HK, Iwagaki H, Hamano R, Kanke T, Liu K, Sadamori H, Yagi T, Yoshino T, Sendo T, Tanaka N, Nishibori M:Effect of adenosine receptor subtypes stimulation on mixed lymphocyte reaction.Eur J Pharmacol, 564(1-3): 204-210, 2007
  25. Takahashi K, Kohno T, Matsumoto S, Nakanishi Y, Arai Y, Fujiwara T, Tanaka N, Yokota J:Clonality and heterogeneity of pulmonary blastoma from the viewpoint of genetic alterations: a case report.Lung Cancer, 57(1):103-108, 2007
  26. Takaki A, Yagi T, Iwasaki Y, Sadamori H, Matsukawa H, Matsuda H, Shinoura S, Umeda Y, Miyake Y, Terada R, Kobashi H, Sakaguchi K, Tanaka N, Shiratori Y:Short-term high-dose followed by long-term low-dose hepatitis B immunoglobulin and lamivudine therapy prevented recurrent hepatitis B after liver transplantation.Transplantation, 83(2): 231-233, 2007
  27. Takahashi HK, Iwagaki H, Hamano R, Kanke T, Liu K, Sadamori H, Yagi T, Yoshino T, Tanaka N, Nishibori M:The immunosuppressive effects of nicotine during human mixed lymphocyte reaction.Eur J Pharmacol, 559(1): 69-74, 2007
  28. Takahashi K, Kohno T, Matsumoto S, Nakanishi Y, Arai Y, Yamamoto S, Fujiwara T, Tanaka N, Yokota J:Clonal and parallel evolution of primary lung cancers and their metastases revealed by molecular dissection of cancer cells.Clin Cancer Res, 13(1): 111-120, 2007
  29. Kammori M, Poon SS, Nakamura K, Izumiyama N, Ishikawa N, Kobayashi M, Naomoto Y, Takubo K:Squamous cell carcinomas of the esophagus arise from a telomere-shortened epithelial field.Int J Mol Med, 20(6): 793-799, 2007
  30. Osawa M, Takigawa N, Kiura K, Ichimura K, Matsuoka J, Hotta K, Tabata M, Tanimoto M:Isolated metastasis of lung cancer to the thyroid gland.Lung Cancer, 58(1): 156-158, 2007
  31. Iguchi T, Matsuoka J, Sato S, Okumura Y, Omori M, Mifune H, Akaki S, Kanazawa S:F-18 FDG PET demonstration of a thyroid metastasis in a patient with colon cancer.Clin Nucl Med, 32(5): 361-362, 2007
  32. Katase N, Nagatsuka H, Tsujigiwa H, Gunduz M, Tamamura R, Pwint HP, Rivera RS, Nakajima M, Naomoto Y, Nagai N:Analysis of the neoplastic nature and biological potential of sporadic and nevoid basal cell carcinoma syndrome-associated keratocystic odontogenic tumor.J Oral Pathol Med, 36(9): 550-554, 2007
  33. Cengiz B, Gunduz M, Nagatsuka H, Beder L, Gunduz E, Tamamura R, Mahmut N, Fukushima K, Ali MA, Naomoto Y, Shimizu K, Nagai N:Fine deletion mapping of chromosome 2q21-37 shows three preferentially deleted regions in oral cancer.Oral Oncol, 43(3): 241-247, 2007
  34. Oka Y, Miyazaki M, Takatsu S, Kunitomo K, Uno F, Maruyama M, Matsuda H:Sevelamer hydrochloride exacerbates metabolic acidosis in hemodialysis patients, depending on the dosage. Ther Apher Dial, 11(2): 107-113, 2007
  35. Kato H, Honma R, Sanda T, Fujiwara T, Ito E, Yanagisawa Y, Imai J, Okamoto T, Watamabe S Biochem Bioph:Knock down of hSNF5/Ini1 causes cell-cycle arrest and apoptosis in a p53-dependent manner. Biochem Bioph Res Com, 361(3): 580-585, 2007
  36. Sung Kwan Shin, Nagasaka T, Barbara H. Jung, Matsubara N, Won Ho Kim, John M. Carethers, C. Richard Boland, Ajay Goel:Epigenetic and Genetic Alterations in Netrin-1 Receptors UNC5C and DCC in Human Colon Cancer.  Gastroenterology, 133: 1849-1857, 2007
  37. Shinagawa N, Fuchimoto S, Sueda T, Hiyama E, Takesue Y, Murakami Y, Ooge H, Uemura K, Mizuno I, Tsumura H, Hirata K, Katsuramaki T, Mizukuchi T, Ushijima Y, Ushida T, Aikawa N, Yo K, Takayama T, Sato T, Kato K, Yura J, Manabe T, Takeyama H, Wakasugi T, Taniguchi M, Yokoyama T, Takeuchi H, Yasui Y, Mashita K, Ikeda S, Yasunami Y, Ryu S, Ishikawa S, Mizuno A, Kubo S, Suehiro S, Fujimoto M, Higaki K, Tanimura H, Taniguchi K, Tsuji T, Ohnishi H, Yamaue H, Kawai M, Tanaka N, Iwagaki H, Kimura H:[Bacteria isolated from surgical infections and its susceptibilities to antimicrobial agents--special references to bacteria isolated between april 2003 and march 2004.Jpn J Antibiot, 60(2): 59-97, 2007
  38. Sadamori H,Yagi T, Matsukawa H, Matsuda H, Shinoura S, Umeda U, Iwamoto, T, Satoh D, Tanaka N:The outcome of living donor liver transplantation with prior spontaneous large portasystemic shunts. Transpl Int,21(2):156-62,2007
  39. Nishida N,Nishimura T, Nagasaka T, Ikai I, Goel A, Boland CR:Extensive methylation is associated with beta-catenin mutations in hepatocellular carcinoma: evidence for two distinct pathways of human hepatocarcinogenesis.Cancer Res,67(10): 4586-4594,2007
  40. Umeda Y, Yagi T, Sadamori H, Matsukawa H, Matsuda H, Shinoura S, Iwamoto T, Satoh D, Iwagaki H, Tanaka N:Preoperative proximal splenic artery embolization: a safe and efficacious portal decompression technique that improves the outcome of live donor liver transplantation.  Transplant International, 20: 947-955, 2007 
  41. Noguchi H, Ueda M, Hayashi S, Kobayashi N, Nagata H, Iwanaga Y, Okitsu T,Matsumoto S:Comparison of M-Kyoto solution and histidine-tryptophan-ketoglutarate solution with a trypsin inhibitor for pancreas preservation in islet transplantation.Transplantation, 84(5): 655-658, 2007
  42. Matsumoto S, Noguchi H, Naziruddin B, Onaca N, Jackson A, Nobuyo H, Okitsu T, Kobayashi N, Klintmalm G, Levy M:Improvement of pancreatic islet cell isolation for transplantation.Proc (Bayl Univ Med Cent), 20(4): 357-362, 2007
  43. Noguchi H, Nakai Y, Ueda M, Masui Y, Futaki S, Kobayashi N, Hayashi S, Matsumoto S:Activation of c-Jun NH2-terminal kinase (JNK) pathway during islet transplantation and prevention of islet graft loss by intraportal injection of JNK inhibitor.Diabetologia, 50(3): 612-619, 2007
  44. Noguchi H, Ueda M, Matsumoto S, Kobayashi N, Hayashi S:BETA2/NeuroD protein transduction requires cell surface heparan sulfate proteoglycans.Hum Gene Ther, 18(1): 10-17, 2007
  45. Parekkadan B, van Poll D, Megeed Z, Kobayashi N, Tilles AW, Berthiaume F, Yarmush ML:Immunomodulation of activated hepatic stellate cells by mesenchymal stem cells.Biochem Biophys Res Commun, 363(2): 247-252, 2007
  46. Navarro Alvarez Nalu, Alejandro Soto Gutierrez, Kobayashi N:Hepatocyte transplantation: a step forward.Curr Organ Transplant, 12: 652-658, 2007
  47. Jorge David Rivas Carrillo, Okitsu T, Kobayashi N:Current cell-based approaches for the treatment of diabetes mellitus.Biotechnol Genet Eng Rev, 24: 281-95, 2007

2006年

  1. Gotohda N, Nishimura M, Yoshida J, Nagai K and Tanaka N:The pattern of Lymphatic Metastases in Superficial Squamous Cell of the Esophagus.Hepato-Gastroenterology, 53(67): 115-119, 2006
  2. Watanabe T, Hioki M, Fujiwara T, Nishizaki M, Kagawa S, Taki M, Kishimoto H, Endo Y, Urata Y, Tanaka N, Fujiwara T:Histone deacetylase inhibitor FR901228 enhances the antitumor effect of telomerase-specific replication-selective adenoviral agent OBP-301 in human lung cancer cells. Exp Cell Res, 312(3): 256-265, 2006
  3. Naka K, H Dansako, N Kobayashi, M Ikeda, N Kato:Hepatitis C virus NS5B delays cell cycle progression by inducing interferon-β via Toll-like receptor 3 signaling pathway without replicating viral genomes.Virology, 346(2): 348-362, 2006
  4. Wynter CV, Kambara T, Walsh MD, Leggett BA, Young J, Jass JR:DNA methylation patterns in adenomas from FAP, multiple adenoma and sporadic colorectal carcinoma patients. Int J Cancer, 118: 907-915, 2006
  5. Imada T, Matsuoka J, Nobuhisa T, Okawa T, Murata T, Tabuchi Y, Shirakawa Y, Ohara N, Gunduz M, Nagatsuka H, Umeoka T, Yamamoto Y, Nakajima M, Tanaka N, Naomoto Y:COX-2 induction by heparanase in the progression of breast cancer.Int J Mol Med, 17(2): 221-228, 2006
  6. Shirakawa Y, Naomoto Y, Noma K, Sakurama K, Nishikawa T, Nobuhisa T, Kobayashi M, Okawa T, Asami S, Yamatsuji T, Haisa M, Matsuoka J, Hanazaki M, Morita K, Hiraki T, Tanaka N:Colonic interposition and supercharge for esophageal reconstruction.Langenbecks Arch Surg, 91(1): 19-23, 2006
  7. Katsuno G, Takahashi HK, Iwagaki H, Mizuno K, Yagi T, Mori S, Saito S, Yoshino T, Nishibori M, Tanaka N: The immunosuppressive effects of ciprofloxacin during human mixed lymphocyte reaction.Clin Immunol, 119(1): 110-119, 2006
  8. Tanaka K, Kobayashi N, Gutierrez AS, Rivas-Carrillo JD, Navarro-Alvarez N, Chen Y, Narushima M, Miki A, Okitsu T, Noguchi H, Tanaka N:Prolonged survival of mice with acute liver failure with transplantation of monkey hepatocytes cultured with an antiapoptotic pentapeptide V5.  Transplantation, 81(3): 427-437, 2006
  9. Fujiwara T, Kagawa S, Kishimoto H, Endo Y, Hioki M, Ikeda Y, Sakai R, Urata Y, Tanaka N, Fujiwara T: Enhanced antitumor efficacy of telomerase-selective oncolytic adenoviral agent OBP-401 with docetaxel: Preclinical evaluation of chemovirotherapy.Int J Cancer, 119: 432-440, 2006
  10. Matsuda H, Yagi T, Sadamori H, Matsukawa H, Shinoura S, Murata H, Umeda Y, Tanaka N:Complications of arterial reconstruction in living donor liver transplantation: a single-center experience.Surg Today, 36(3): 245-251, 2006
  11. Fujiwara T, Tanaka N, Kanazawa S, Ohtani S, Saijo Y, Nukiwa T, Yoshimura K, Sato T, Eto Y, Chada S, Nakamura H, Kato H:Multicenter phase I study of repeated intratumoral delivery of adenoviral p53in patients with advanced non-small-cell lung cancer.J Clin Oncol, 24(11): 1689-1699, 2006
  12. Katsuno G, Takahashi HK, Iwagaki H, Sugita S, Mori S, Saito S, Yoshino T, Nishibori M, Tanaka N:The effect of ciprofloxacin on CD14 and toll-like receptor-4 expression on human monocytes.  Shock, 25(3): 247-253, 2006
  13. Fujiwara T, Naomoto Y, Yamatsuji T, Shirakawa Y, Noguchi H, Fujiwara T, Oohara N, Gunduz M, Nagatsuka H, Nishie M, Uetsuka H, Hamazaki S, Tanaka N:Three Cases of Adenocarcinoma Arising in Extremely Long-Segment Barrett's Esophagus.Dig Dis Sci, 51(3): 533-538, 2006
  14. Takahashi K, Kohno T, Ajima R, Sasaki H, John D. MINNA, Fujiwara T, Tanaka N, Yokota J:Homozygous deletion and reduces expression of the DOCK8 gene in human lung cancer.International Journal Oncology, 28: 321-328, 2006
  15. Ikeda H , Kobayashi N, Tanaka Y, Nakaji S, Yong C, Okitsu T, Oshita M, Matsumoto S, Noguchi H, Narushima M, Tanaka K, Miki A, Rivas-Carrillo JD, Soto-Gutierrez A, Navarro-Alvarez N, Tanaka K, Jun HS, Tanaka N, Yoon JW:A newly developed bioartificial pancreas successfully controls blood glucose in totally pancreatectomized diabetic pigs.Tissue Eng, 12(7): 1799-1809, 2006
  16. Kobayashi M, Naomoto Y, Nobuhisa T, Okawa T, Takaoka M, Shirakawa Y, Yamatsuji T, Matsuoka J, Mizushima T, Matsuura H, Nakajima M, Nakagawa H, Rustgi A, Tanaka N:Heparanase regulates esophageal keratinocyte differentiation through nuclear translocation and heparan sulfate cleavage.Differentiation, 74(5): 235-43, 2006
  17. Kishimoto H, Kojima T, Watanabe Y, Kagawa S, Fujiwara T, Uno F, Teraishi F, Kyo S, Mizuguchi H, Hashimoto Y, Urata Y, Tanaka N, Fujiwara T:In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus.Nat Med, 1213-1219, 2006
  18. Hamano R, Takahashi HK, Iwagaki H, Yoshino T, Nishibori M, Tanaka N:STIMULATION OF alpha7 NICOTINIC ACETYLCHOLINE RECEPTOR INHIBITS CD14 AND THE TOLL-LIKE RECEPTOR 4 EXPRESSION IN HUMAN MONOCYTES.Shock, 358-364, 2006
  19. Takahashi HK, Iwagaki H, Hamano R, Yoshino T, Tanaka N, Nishibori M:Effect of nicotine on IL-18-initiated immune response in human monocytes.J Leukoc Biol, 80(6): 1388-1394, 2006
  20. Takahashi HK, Iwagaki H, Hamano R, Yoshino T, Tanaka N, Nishibori M:alpha7 Nicotinic Acetylcholine Receptor Stimulation Inhibits Lipopolysaccharide-Induced Interleukin-18 and -12 Production in Monocytes.J Pharmacol Sci, 102(1): 143-146, 2006
  21. Fukazawa T, Matsuoka J, Naomoto Y, Nakai T, Durbin ML, Kojima I, Lakey JR, Tanaka N:Development of a novel beta-cell specific promoter system for the identification of insulin-producing cells in vitro cell cultures. Exp Cell Res, 312(17): 3404-3412, 2006
  22. Soto-Gutierrez A, Kobayashi N, Rivas-Carrillo JD, Navarro-Alvarez N, Zhao D, Okitsu T, Noguchi H, Basma H, Tabata Y, Chen Y, Tanaka K, Narushima M, Miki A, Ueda T, Jun HS, Yoon JW, Lebkowski J, Tanaka N, Fox IJ:Reversal of mouse hepatic failure using an implanted liver-assist device containing ES cell-derived hepatocytes.Nat Biotechnol, 24(11): 1412-1419, 2006
  23. Miyaso H, Morimoto Y, Ozaki M, Haga S, Shinoura S, Choda Y, Murata H, Katsuno G, Huda K, Takahashi H, Tanaka N, Iwagaki H:Protective effects of nafamostat mesilate on liver injury induced by lipopolysaccharide in rats: possible involvement of CD14 and TLR-4 downregulation on Kupffer cells.DIGESTIVE DISEASES AND SCIENCES, 51(11): 2007-2012, 2006
  24. Nagasaka T, Goel A, Matsubara N, Tanaka N:Detection of fecal DNA methylation for colorectal neoplasia: does it lead to an optimal screening test? Acta Med Okayama, 249-256, 2006
  25. Ohtawa Y, Naomoto Y, Shirakawa Y, Takaoka M, Murata T, Sonoda R, Sakurama K, Yamatsuji T, Gunduz M, Tsujigiwa H, Nagatsuka H, Terada N, Itano S, Horiki S, Yanagihara K, Nakajima M, Tanaka N:The close relationship between heparanase and cyclooxygenase-2 expressions in signet-ring cell carcinoma of the stomach.Hum Pathol, 37(9): 1145-1152, 2006
  26. Ozaki K, Nagasaka T, Notohara K, Kambara T, Takeda M, Sasamoto H, Jass JR, Tanaka N, Matsubara N:Heterogeneous microsatellite instability observed within epithelium of ulcerative colitis.Int J Cancer, 119(11): 2513-2519, 2006
  27. Teraishi F, Fujiwara T, Jikuhara A, Kamitani S, Morino Y, Sato K, Tanaka N:Esophageal intramural pseudodiverticulosis with esophageal strictures successfully treated with dilation therapy.Ann Thorac Surg, 82(3): 1119-1121, 2006
  28. Soto-Gutierrez A, Navarro-Alvarez N, Rivas-Carrillo JD, Chen Y, Yamatsuji T, Tanaka N, Kobayashi N:Differentiation of human embryonic stem cells to hepatocytes using deleted variant of HGF and poly-amino-urethane-coated nonwoven polytetrafluoroethylene fabric.Cell Transplant, 15(4): 335-341, 2006
  29. Miki A, Narushima M, Okitsu T, Takeno Y, Soto-Gutierrez A, Rivas-Carrillo JD, Navarro-Alvarez N, Chen Y, Tanaka K, Noguchi H, Matsumoto S, Kohara M, Lakey JR, Kobayashi E, Tanaka N, Kobayashi N:Maintenance of mouse, rat, and pig pancreatic islet functions by coculture with human islet-derived fibroblasts.Cell Transplant, 15(4): 325-334, 2006
  30. Hiraki T, Gobara H, Takemoto M, Mimura H, Mukai T, Himei K, Hase S, Iguchi T, Fujiwara H, Yagi T, Tanaka N, Kanazawa S:Percutaneous radiofrequency ablation combined with previous bronchial arterial chemoembolization and followed by radiation therapy for pulmonary metastasis from hepatocellular carcinoma.J Vasc Interv Radiol, 17(7): 1189-1193, 2006
  31. Takahashi HK, Watanabe T, Yokoyama A, Iwagaki H, Yoshino T, Tanaka N, Nishibori M:Cimetidine induces interleukin-18 production through H2-agonist activity in monocytes.Mol Pharmacol, 70(2): 450-453, 2006
  32. Noguchi H, Matsumoto S, Matsushita M, Kobayashi N, Tanaka K, Matsui H, Tanaka N:Immunosuppression for islet transplantation.Acta Med Okayama, 60(2): 71-76, 2006
  33. Yamatsuji T, Naomoto Y, Shirakawa Y, Gunduz M, Hiraki T, Yasui K, Kawata M, Hanazaki M, Morita K, Sano S, Tanaka N, Kanazawa S:Intra-aortic stent graft in oesophageal carcinoma invading the aorta. Prophylaxis for fatal haemorrhage.Int J Clin Pract, 60(12): 1600-1603, 2006
  34. Huda KA, Guo L, Haga S, Murata H, Ogino T, Fukai M, Yagi T, Iwagaki H, Tanaka N, Ozaki M:Ex vivo adenoviral gene transfer of constitutively activated STAT3 reduces post-transplant liver injury and promotes regeneration in a 20% rat partial liver transplant model.Transpl Int, 19(5): 415-423, 2006
  35. Fujiwara T, Naomoto Y, Yamatsuji T, Shirakawa Y, Noguchi H, Fujiwara T, Oohara N, Gunduz M, Nagatsuka H, Nishie M, Uetsuka H, Hamazaki S, Tanaka N:Three cases of adenocarcinoma arising in extremely long-segment Barrett's esophagus.Dig Dis Sci, 51(3): 533-538, 2006
  36. Maeda Y, Hwang-Verslues WW, Wei G, Fukazawa T, Durbin ML, Owen LB, Liu X, Sladek FM:Tumour suppressor p53 down-regulates the expression of the human hepatocyte nuclear factor 4alpha (HNF4alpha) gene.Biochem J,  400(2): 303-313, 2006
  37. Hui-Ying Qiu, Fujimori Y, Nishioka K, Yamaguchi N, Hashimoto-Tamaoki T, Sugihara A, Terada N, Nagaya N, Kanda M, Kobayashi N, Tanaka N, A Westerman Karen, Philippe Leboulch, Hara H:Postnatal neovascularization by endothelial progenitor cells immortalized with the simian virus 40T antigen gene.Int J Oncol , 28(4): 815-821, 2006
  38. Matsumoto S, Noguchi H,Yonekawa Y, Okitsu T, Iwanaga Y, Xiaoling Liu, Nagata H, Kobayashi N, Camillo Ricordi:Pancreatic islet transplantation for treating diabetes.Expert Opin Biol Ther, 6(1): 23-37, 2006, 2006
  39. Rivas-Carrillo JD, Navarro-Alvarez N, Soto-Gutierrez A, Okitsu T, Chen Y, Tabata Y, Misawa H, Noguchi H, Matsumoto S, Tanaka N, Kobayashi N:Amelioration of diabetes in mice after single-donor islet transplantation using the controlled release of gelatinized FGF-2.Cell Transplant, 15(10): 939-944, 2006
  40. Navarro-Alvarez N, Soto-Gutierrez A, Rivas-Carrillo JD, Chen Y, Yamamoto T, Yuasa T, Misawa H, Takei J, Tanaka N, Kobayashi N:Self-assembling peptide nanofiber as a novel culture system for isolated porcine hepatocytes.Cell Transplant, 15(10): 921-927, 2006
  41. Misawa H, Kobayashi N, Soto-Gutierrez A, Chen Y, Yoshida A, Rivas-Carrillo JD, Navarro-Alvarez N, Tanaka K, Miki A, Takei J, Ueda T, Tanaka M, Endo H, Tanaka N, Ozaki T:PuraMatrix facilitates bone regeneration in bone defects of calvaria in mice.Cell Transplant, 15(10): 903-910, 2006
  42. Miki A, Rivas-Carrillo JD, Navarro-Alvarez N, Soto-Gutierrez A, Chen Y, Tanaka K, Narushima M, Tabata Y, Okitsu T, Noguchi H, Matsumoto S, Tanaka N, Kobayashi N:Maintenance of neovascularization at the implantation site of an artificial device by bFGF and endothelial cell transplant.Cell Transplant, 15(10): 893-901, 2006
  43. Chen Y, Soto-Gutierrez A, Navarro-Alvarez N, Rivas-Carrillo JD, Yamatsuji T, Shirakawa Y, Tanaka N, Kobayashi N:Instant hepatic differentiation of human embryonic stem cells using activin A and a deleted variant of HGF.Cell Transplant, 15(10): 865-871, 2006
  44. Tanaka K, Soto-Gutierrez A, Navarro-Alvarez N, Rivas-Carrillo JD, Jun HS, Kobayashi N:Functional hepatocyte culture and its application to cell therapies.Cell Transplant, 15(10): 855-864, 2006
  45. Teraishi F, Uno F, Kagawa S, Gochi A, Fujiwara T, Tanaka N:A case report--The marked response to gemcitabine combined with irinotecan and low-dose cisplatin chemotherapy for advanced gastric cancer with multiple liver metastases.Gan To Kagaku Ryoho, 33(12): 1885-1887, 2006
  46. Hideo Kohka Takahashi 1, Hiromi Iwagaki 2, Ryosuke Hamano 2, Tadashi Yoshino 3, Noriaki Tanaka 2, Masahiro Nishibori 1, Departments of 1 Pharmacology, 2 Gastroenterological Surgery, and 3 Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Science: Nicotinic Acetyicholine Receptor Stimulation Inhibits Lipopolysaccharide-Induced Interleukin-18 and -12 Production in Monocytes.Journal of Pharmacological Sciences, 102(1) : 143-146, 2006
  47. Sadamoti H, Yagi T, Matsukawa H, Matsuda H, Shinoura S, Umeda Y, Narushima M, Tanaka N:Successful Re-transection of Conglutinated Hepatic Resection Plane for Repeate Systematized Hepatectomy.Hepatogastroenterology, 2006
  48. Kagawa S, Fujiwara T, Tokunaga N, Nishizaki M, Uno F, Teraishi F, Gouchi A, Matsuoka J, Tanaka N:A case of advanced gastric cancer with liver metastasis completely responding to CPT-11+low-dose 5-FU+CDDP chemotherapy.Gan To Kagaku Ryoho, 33(9): 1317-1320, 2006

2005年

  1. Nobuhisa T, Naomoto Y, Ohkawa T, Takaoka M, Ono R, Murata T, Gunduz M, Shirakawa Y, Yamatsuji T, Haisa M, Matsuoka J, Tsujigiwa H, Nagatsuka H, Nakajima M, Tanaka N:Heparanase expression correlates with malignant potential in human colon cancer.Journal Cancer Research Clinical Oncology,131(4): 229-237,2005
  2. Shima Y, Yagi T, Inagaki M, Sadamori H, Tanaka N, Horimi T, Hamazaki S:Intraductal oncocytic papillary neoplasm of the pancreas with celiac artery compression syndrome and a jejunal artery aneurysm: report of a case.Surgery Today,35(1): 86-90,2005
  3. Takahashi HK, Mori S, Iwagaki H, Yoshino T, Tanaka N, Weitz-Schmidt G, Nishibori M:Differential effect of LFA703, pravastatin, and fluvastatin on production of IL-18 and expression of ICAM-1 and CD40 in human monocytes.J Leukoc Biol,77(3): 400-407,2005
  4. Takahashi HK, Iwagaki H, Tamura R, Katsuno G, Xue D, Sugita S, Mori S, Yoshino T, Tanaka N, Nishibori M:alpha1-Adrenergic Receptor Antagonists Induce Production of IL-18 and Expression of ICAM-1 and CD40 in Human Monocytes.J Immunother,28(1): 40-43,2005
  5. Sun DS, H Iwagaki, M Ozaki, T Ogino, S Kusaka, Y Fujimoto, H Murata, H Sadamori, H Matsukawa, N Tanaka, T Yagi:Prolonged survival of donor-specific rat intestinal allograft by intraportal administration of bone-marrow-derived immature dendritic cells. Transplant Immunology,14: 17-20,2005
  6. Murakami T, Iwagaki H, Saito S, Ohtani S, Kuroki K, Kuinose M, Tanaka N and Tanemoto K:Equivalence of the Acute Ctokine Surge and Myocardial Injury after Coronary Artery Bypass Grafting With and Without a Novel Extracorporeal Circulation System.The Journal of International Medical Research,33: 133-149,2005
  7. Nakajo T, Yamatsuji T, Ban H, Shigemitsu K, Haisa M, Motoki T, Noma K, nobuhisa T, Matsuoka J, Gunduz M, Yonezawa K, Tanaka N, Naomoto Y:Glutamine is a key regulator for amino acid-controlled cell growth though the mTOR signaling pathway in rat intestinal epithelial cells.Biochemical and Biophysical Research Communications,326(1): 174-180,2005
  8. Tokunaga N, Murakami T, Endo Y, Nishizaki M, Kagawa S, Tanaka N and Fujiwara T:human Monocyte-Derived Dendritic Cells Pulsed with Wild-Type p53 Protein Efficiently Induce CTLs against p53 Overexpressing Human Cancer Cells.Clinical Cancer Research,11: 1312-1318,2005
  9. Kimura N, Nagasaka T, Murakami J, Sasamoto H, Murakami M, Tanaka N, Matsubara N:Methylatio profiles of genes utilizing newly developed CpG island methylation microarray on colorectal cancer patients.Nucleic Acids Res, 33(5): e46,2005
  10. Takahashi HK, Xue D, Iwagaki H, Tamura R, Katsuno G, Yagi T, Yoshino T, Mori S, Nishibori M, Tanaka N:Prostaglandin E1-initiated immune regulation during human mixed lymphocyte reaction.Clin Immunol,115(1): 85-92,2005
  11. Nobuhisa T, Naomoto Y, Takaoka M, Tabuchi Y, Ookawa K, Kitamoto D, Gunduz E, Gunduz M, Nagatsuka H, Haisa M, Matsuoka J, Nakajima M, Tanaka N:Emergence of nuclear heparanase induces differentiation of human mammary cancer cells.Biochem Biophys Res Commun, 31(1): 175-180,2005
  12. Takahashi HK, Iwagaki H, Tamura R, Katsuno G, Xue D, Sugita S, Mori S, Yoshino T, Tanaka N, Nishibori M:Differential effect of prostaglandins E1 and E2 on lipopolysaccharide-induced adhesion molecule expression on human monocytes.Eur J Pharmacol,512(2-3): 223-230,2005
  13. Kobayashi N, Rivas-Carrillo JD, Soto-Gutierrez A, Fukazawa T, Chen Y, Navarro-Alvarez N, Tanaka N:Gene delivery to embryonic stem cells.Birth Defects Res C Embryo Today,75(1): 10-8, 2005
  14. Murakami J, Asaumi J, Kawai N, Tsujigiwa H, Yanagi Y, Nagatsuka H, Inoue T, Kokeguchi S, Kawasaki S, Kuroda M, Tanaka N, Matsubara N, Kishi K:Effects of histone deacetylase inhibitor FR901228 on the expression level of telomerase reverse transcriptase in oral cancer.Cancer Chemother Pharmacol,56(1): 22-28,2005
  15. Takahashi HK, Iwagaki H, Tamura R, Yagi T, Yoshino T, Mori S, Tanaka N, Nishibori M:Effect of antibodies against intercellular adhesion molecule-1, B7, and CD40 on interleukin-18-treated human mixed lymphocyte reaction.J Pharmacol Sci,97(3): 447-450,2005
  16. Taki M, Kagawa S, Nishizaki M, Mizuguchi H, Hayakawa T, Kyo S, Nagai K, Urata Y, Tanaka N, Fujiwara T:Enhanced oncolysis by a tropism-modified telomerase-specific replication-selective adenoviral agent OBP-405 ('Telomelysin-RGD').Oncogene,24(19):3130-3140,2005
  17. Joanne young, Melissa A. Barker, Lisa A Simms, Michal D. Walsh, Kelli G. Biden, Daniel Buchanan, Ron Buttenshaw, Vicki J. Whitehall, Sven Arnold, Leigh Jackson, Kambara T, Kevin J. Spring, mark A. Jenkins, Graeme J Walker, John L. Hopper, Barbara A. Leggett and Jeremy R. Jass:Evidence for BRAF Mutation and Variable Levels of Microsatellite Instability in an Syndrome of Familial Colorectal Cancer.CLINICAL GASTROENTETROLOGY AND HEPATOLOGY,3: 254-263,2005
  18. Fujimoto Y, Iwagaki H, Ozaki M, Ogino T, Murata H, Sun DS, Sadamori H, Takahashi HK, Tanaka N, Yagi T:Involvement of prostaglandin receptors (EPR2-4) in in vivo immunosuppression of PGE2 in rat skin transplant model.INTERNATIONAL IMMUNOPHARMACOLOGY,5(7-8): 1131-1139,2005
  19. Narushima M, Kobayashi N, Okitsu T, Tanaka Y, Li SA, Chen Y, Miki A, Tanaka K, Nakaji S, Takei K, Gutierrez AS, Rivas-Carrillo JD, Navarro-Alvarez N, Jun HS, Westerman KA, Noguchi H, Lakey JR, Leboulch P, Tanaka N, Yoon JW:A human beta-cell line for transplantation therapy to control type 1 diabetes.Nat Biotechnol,23(10): 1274-1282,2005
  20. Morishita N, Nakagami H, Morishita R, Takeda S, Mishima F, Terazono B, Nishijima S, Kaneda Y, Tanaka N:Magnetic nanoparticles with surface modification enhanced gene delivery of HVJ-E vector.Biochem Biophys Res Commun,334(4): 1121-1126,2005
  21. Yoshii M, Jikuhara A, Mori S, Iwagaki H, Takahashi HK, Nishibori M, Tanaka N:Mast cell tryptase stimulates DLD-1 carcinoma through prostaglandin- and MAP kinase-dependent manners.J Pharmacol Sci,98(4): 450-458,2005
  22. Katsuno G, Takahashi HK, Iwagaki H, Mizuno K, Mori S, Yoshino T, Nishibori M, Tanaka N:Nafamostat mesilate induces production of interleukin-12 and -18 in human peripheral blood mononuclear cells. J Pharmacol Sci,98(4): 463-466,2005
  23. Noma K, Naomoto Y, Gunduz M, Matsuoka J, Yamatsuji T, Shirakawa Y, Nobuhisa T, Okawa T, Takaoka M, Tomono Y, Hiroyuki O, Gunduz E, Tanaka N:Effects of imatinib vary with the types of KIT-mutation in gastrointestinal stromal tumor cell lines.Oncol Rep,14(3):645-650,2005
  24. Takahashi HK, Iwagaki H, Xue D, Katsuno G, Sugita S, Mizuno K, Mori S, Saito S, Yoshino T, Tanaka N, Nishibori M:Effect of ciprofloxacin-induced prostaglandin E2 on interleukin-18-treated monocytes. Antimicrob Agents Chemother,49(8): 3228-3233,2005
  25. Maki Y, Murakami J, Asaumi J, Tsujigiwa H, Nagatsuka H, Kokeguchi S, Fukui K, Kawai N, Yanagi Y, Kuroda M, Tanaka N, Matsubara N, Kishi K:Role of O(6)-methylguanine-DNA methyltransferase and effect of O(6)-benzylguanine on the anti-tumor activity of cis-diaminedichloroplatinum(II) in oral cancer cell lines.Oral Oncol. 41(10): 984-993,2005
  26. Teraishi F, Kagawa S, Watanabe T, Tango Y, Kawashima T, Umeoka T, Nisizaki M, Tanaka N, Fujiwara T: ZD1839 (Gefitinib, 'Iressa'), an epidermal growth factor receptor-tyrosine kinase inhibitor, enhances the anti-cancer effects of TRAIL in human esophageal squamous cell carcinoma.FEBS Lett. 579(19): 4069-4075,2005
  27. Naomoto Y, Yamatsuji T, Shigemitsu K, Ban H, Nakajo T, Shirakawa Y, Motok T, Kobayashi M, Gunduz M, Tanaka N:Rational role of amino acids in intestinal epithelial cells (Review). Int J Mol Med. 16(2): 201-204. 2005
  28. Mizuno K, Takahashi HK, Iwagaki H, Katsuno G, Kamurul HA, Ohtani S, Mori S, Yoshino T, Nishibori M, Tanaka N:Beta2-adrenergic receptor stimulation inhibits LPS-induced IL-18 and IL-12 production in monocytes.Immunol Lett,101(2): 168-172,2005
  29. Takahashi HK, Iwagaki H, Mori S, Yoshino T, Tanaka N, Nishibori M:Prostaglandins E1 and E2 inhibit lipopolysaccharide-induced interleukin-18 production in monocytes.Eur J Pharmacol,517(3): 252-256,2005
  30. Naomoto Y, Takaoka M, Okawa T, Nobuhisa T, Gunduz M, Tanaka N:The role of heparanase in gastrointestinal cancer (Review).Oncol Rep. 14(1): 3-8,2005
  31. Hamanaka S, Tanemoto K, Inagaki E, Yamasawa T, Yoshida K, Mochizuki S, Goto M, Miyasaka T, Kajiya F, Tanaka N:Direct measurement of nitric oxide during experimental cardiopulmonary bypass.J Int Med Res,33(3): 295-300,2005
  32. Takahashi HK, Mori S, Iwagaki H, Yoshino T, Tanaka N, Nishibori M:Simvastatin induces interleukin-18 production in human peripheral blood mononuclear cells.Clin Immunol,116(3): 211-216,2005
  33. Chen Y, Kobayashi N, Suzuki S, Soto-Gutierrez A, Rivas-Carrillo JD, Tanaka K, Navarro-Alvarez N, Fukazawa T, Narushima M, Miki A, Okitsu T, Amemiya H, Tanaka N:Transplantation of human hepatocytes cultured with deleted variant of hepatocyte growth factor prolongs the survival of mice with acute liver failure.Transplantation,79(10): 1378-1385,2005
  34. Shiratori Y, Ito Y, Yokosuka O, Imazeki F, Nakata R, Tanaka N, Arakawa Y, Hashimoto E, Hirota K, Yoshida H, Ohashi Y, Omata M:Tokyo-Chiba Hepatitis Research Group:Antiviral therapy for cirrhotic hepatitis C: association with reduced hepatocellular carcinoma development and improved survival.Ann Intern Med. 142(2): 105-114,2005
  35. Miyaso H, Morimoto Y, Ozaki M, Haga S, Shinoura S, Choda Y, Iwagaki H, Tanaka N:Obstructive jaundice increases sensitivity to lipopolysaccharide via TLR4 upregulation: Possible involvement in gut-derived hepatocyte growth factor-protection of hepatocytes. J Gastroenterol Hepatol,20(12): 1859-1866,2005
  36. Okawa T, Naomoto Y, Nobuhisa T, Takaoka M, Motoki T, Shirakawa Y, Yamatsuji T, Inoue H, Ouchida M, Gunduz M, Nakajima M, Tanaka N:Heparanase is involved in angiogenesis in esophageal cancer through induction of cyclooxygenase-2.Clin Cancer Res. 11(22): 7995-8005,2005
  37. Teraishi F, Zhang L, Guo W, Dong F, Davis JJ, Lin A, Fang B:Activation of c-Jun NH2-terminal kinase is required for gemcitabine's cytotoxic effect in human lung cancer H1299 cells. FEBS Lett,579(29):6681-6687,2005
  38. Teraishi F, Wu S, Inoue S, Zhang L, Davis JJ, Guo W, Dong F, Fang B:Antitumor activity and downregulation of pro-angiogenic molecules in human prostate cancer cells by a novel thiazolidione compound. The Prostate,1-9,2005
  39. Teraishi F, Wu S, Sasaki J, Zhang L, Davis JJ, Guo W, Dong F, Fang B:JNK1-dependent antimitotic activity of thiazolidin compounds in human non-small-cell lung and colon cancer cells. Cell Mol Life Sci. 62(19-20): 2382-2389,2005
  40. Teraishi F, Wu S, Zhang L, Guo W, Davis JJ, Dong F, Fang B:Identification of a novel synthetic thiazolidin compound capable of inducing c-Jun NH2-terminal kinase-dependent apoptosis in human colon cancer cells. Cancer Res. 65(14): 6380-6387,2005
  41. Teraishi F, Wu S, Sasaki J, Zhang L, Zhu HB, Davis JJ, Fang B:P-glycoprotein-independent apoptosis induction by a novel synthetic compound, MMPT [5-[(4-methylphenyl)methylene]-2-(phenylamino)-4(5H)-thiazolone]. J Pharmacol Exp Ther. 314(1): 355-362,2005
  42. Zhu H, Zhang L, Dong F, Guo W, Wu S, Teraishi F, Davis JJ, Chiao PJ, Fang B:Bik/NBK accumulation correlates with apoptosis-induction by bortezomib (PS-341, Velcade) and other proteasome inhibitors.Oncogene,24(31): 4993-4999,2005
  43. Zhang L, Zhu H, Teraishi F, Davis JJ, Guo W, Fan Z, Fang B:Accelerated degradation of caspase-8 protein correlates with TRAIL resistance in a DLD1 human colon cancer cell line. Neoplasia,7(6): 594-602, 2005
  44. Kobayashi N:Current trend of islet transplantation. Organ Biology,12(1): 29-37,2005
  45. N Kobayashi, Jorge David Rivas-Carrillo, Alejandro Soto-Gutierrez, T Fukazawa, Yong Chen, Nalu Navarro-Alvarez, N Tanaka:Gene delivery to embryonic stem cells. Birth Defects Research (Part C): Embryo Today,75(1): 10-18,2005
  46. Arima Y, Nitta M, Kuninaka S, Zhang D, Fujiwara T, Taya Y, Nakao M, Saya H:Transcriptional Blockade Induces p53-dependent Apoptosis Associated with Translocation of p53 to Mitochondria.J Biol Chem,280: 19166-19176,2005
  47. Kondo E, Shibata M, Kimura T, Iwagaki H, Nakamura S, Tanaka T, Ohara N, Ichimura  K, Oka T, Yanai H, Shibasaki F, Yoshino T:Expression of Phosphorylated Ser70 of Bcl-2 Correlates with Malignancy in Human Colorectal Neoplasms.Human Cancer Biology,11(20): 7255-7263,2005